OBJECTIVE: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. METHODS: In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18-29) and the later adult onset group (age 30-44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images. RESULTS: Widespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group. CONCLUSIONS: The GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.
OBJECTIVE: Little is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD. METHODS: In present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18-29) and the later adult onset group (age 30-44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images. RESULTS: Widespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDDpatients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group. CONCLUSIONS: The GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.
Entities:
Keywords:
Different age at onset; Grey matter volume; Magnetic resonance imaging; Major depressive disorder
Authors: Ming-Ying Du; Qi-Zhu Wu; Qiang Yue; Jun Li; Yi Liao; Wei-Hong Kuang; Xiao-Qi Huang; Raymond C K Chan; Andrea Mechelli; Qi-Yong Gong Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2011-10-07 Impact factor: 5.067
Authors: Gabriel S Dichter; Jennifer N Felder; James W Bodfish; Linmarie Sikich; Aysenil Belger Journal: Soc Cogn Affect Neurosci Date: 2008-11-16 Impact factor: 3.436
Authors: Robyn Bluhm; Peter Williamson; Ruth Lanius; Jean Théberge; Maria Densmore; Robert Bartha; Richard Neufeld; Elizabeth Osuch Journal: Psychiatry Clin Neurosci Date: 2009-12 Impact factor: 5.188
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: Adrian J Lloyd; I Nicol Ferrier; Robert Barber; Anil Gholkar; Allan H Young; John T O'Brien Journal: Br J Psychiatry Date: 2004-06 Impact factor: 9.319
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Doreen Koretz; Kathleen R Merikangas; A John Rush; Ellen E Walters; Philip S Wang Journal: JAMA Date: 2003-06-18 Impact factor: 56.272
Authors: Lianne Schmaal; Elena Pozzi; Tiffany C Ho; Laura S van Velzen; Ilya M Veer; Nils Opel; Eus J W Van Someren; Laura K M Han; Lybomir Aftanas; André Aleman; Bernhard T Baune; Klaus Berger; Tessa F Blanken; Liliana Capitão; Baptiste Couvy-Duchesne; Kathryn R Cullen; Udo Dannlowski; Christopher Davey; Tracy Erwin-Grabner; Jennifer Evans; Thomas Frodl; Cynthia H Y Fu; Beata Godlewska; Ian H Gotlib; Roberto Goya-Maldonado; Hans J Grabe; Nynke A Groenewold; Dominik Grotegerd; Oliver Gruber; Boris A Gutman; Geoffrey B Hall; Ben J Harrison; Sean N Hatton; Marco Hermesdorf; Ian B Hickie; Eva Hilland; Benson Irungu; Rune Jonassen; Sinead Kelly; Tilo Kircher; Bonnie Klimes-Dougan; Axel Krug; Nils Inge Landrø; Jim Lagopoulos; Jeanne Leerssen; Meng Li; David E J Linden; Frank P MacMaster; Andrew M McIntosh; David M A Mehler; Igor Nenadić; Brenda W J H Penninx; Maria J Portella; Liesbeth Reneman; Miguel E Rentería; Matthew D Sacchet; Philipp G Sämann; Anouk Schrantee; Kang Sim; Jair C Soares; Dan J Stein; Leonardo Tozzi; Nic J A van Der Wee; Marie-José van Tol; Robert Vermeiren; Yolanda Vives-Gilabert; Henrik Walter; Martin Walter; Heather C Whalley; Katharina Wittfeld; Sarah Whittle; Margaret J Wright; Tony T Yang; Carlos Zarate; Sophia I Thomopoulos; Neda Jahanshad; Paul M Thompson; Dick J Veltman Journal: Transl Psychiatry Date: 2020-05-29 Impact factor: 6.222