BACKGROUND: Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology. AIMS: To compare hippocampal and white matter structural change in demographically matched controls and participants with early-onset and late-onset depression. METHOD: High-resolution volumetric magnetic resonance imaging (MRI) and rating of MRI hyperintensities. RESULTS: A total of 51 people with depression and 39 control participants were included. Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. Hippocampal volumes did not differ between control participants and those with early-onset depression. Age of depression onset correlated (negatively) with hippocampal volume but lifetime duration of depression did not. Hyperintensity ratings did not differ between groups. CONCLUSIONS: Results suggest that acquired biological factors are of greater importance in late-than in early-onset illness and that pathological processes other than exposure to hypercortisolaemia of depression underlie hippocampal atrophy in depression of late life.
BACKGROUND: Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology. AIMS: To compare hippocampal and white matter structural change in demographically matched controls and participants with early-onset and late-onset depression. METHOD: High-resolution volumetric magnetic resonance imaging (MRI) and rating of MRI hyperintensities. RESULTS: A total of 51 people with depression and 39 control participants were included. Participants with late-onset depression had bilateral hippocampal atrophy compared with those with early-onset depression and controls. Hippocampal volumes did not differ between control participants and those with early-onset depression. Age of depression onset correlated (negatively) with hippocampal volume but lifetime duration of depression did not. Hyperintensity ratings did not differ between groups. CONCLUSIONS: Results suggest that acquired biological factors are of greater importance in late-than in early-onset illness and that pathological processes other than exposure to hypercortisolaemia of depression underlie hippocampal atrophy in depression of late life.
Authors: Marina Boccardi; Rossana Ganzola; Martina Bocchetta; Michela Pievani; Alberto Redolfi; George Bartzokis; Richard Camicioli; John G Csernansky; Mony J de Leon; Leyla deToledo-Morrell; Ronald J Killiany; Stéphane Lehéricy; Johannes Pantel; Jens C Pruessner; H Soininen; Craig Watson; Simon Duchesne; Clifford R Jack; Giovanni B Frisoni Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472
Authors: Jonathan H Morra; Zhuowen Tu; Liana G Apostolova; Amity E Green; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Xue Hua; Arthur W Toga; Clifford R Jack; Norbert Schuff; Michael W Weiner; Paul M Thompson Journal: Hum Brain Mapp Date: 2009-09 Impact factor: 5.038
Authors: Yi-Yu Chou; Natasha Leporé; Christina Avedissian; Sarah K Madsen; Neelroop Parikshak; Xue Hua; Leslie M Shaw; John Q Trojanowski; Michael W Weiner; Arthur W Toga; Paul M Thompson Journal: Neuroimage Date: 2009-02-21 Impact factor: 6.556
Authors: Martina Ballmaier; Katherine L Narr; Arthur W Toga; Virginia Elderkin-Thompson; Paul M Thompson; Liberty Hamilton; Ebrahim Haroon; Daniel Pham; Andreas Heinz; Anand Kumar Journal: Am J Psychiatry Date: 2007-11-06 Impact factor: 18.112
Authors: P Cédric M P Koolschijn; Neeltje E M van Haren; Gerty J L M Lensvelt-Mulders; Hilleke E Hulshoff Pol; René S Kahn Journal: Hum Brain Mapp Date: 2009-11 Impact factor: 5.038