Christian Samsonsen1, Trond Sand2, Geir Bråthen2, Grethe Helde3, Eylert Brodtkorb2. 1. Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway; Department of Neuroscience, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: christian.samsonsen@stolav.no. 2. Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway; Department of Neuroscience, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. 3. Department of Neuroscience, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Abstract
PURPOSE: The relationship between sleep and seizures is intricate. The aim of this study was to assess whether sleep loss is an independent seizure precipitant in a clinical setting. METHODS: In this prospective, observational cross-over study, 179 consecutive hospital admissions for epileptic seizures were included. A semi-structured interview regarding several seizure precipitants was performed. The sleep pattern prior to the seizure, as well as alcohol, caffeine and drug use, were recorded. The interview was repeated by telephone covering the same weekday at a time when there had been no recent seizure. The Hospital Anxiety and Depression Scale (HADS) and a visual analogue scale for perceived stress were applied at admission. Student's t-test, Fisher exact test and ANOVA were used for statistical analyses. RESULTS: Complete data for analysis were retrieved in 144 patients. The sleep-time during the 24h prior to the seizure was lower (7.3h) compared to follow-up (8.3h; p<0.0005). Caffeine consumption and use of relevant non antiepileptic drugs (AED) were not different. HADS and stress scores at admission did not correlate with sleep-time difference. In ANOVA, controlled for alcohol consumption and AED use, the sleep-time difference remained significant (p=0.008). The interaction with alcohol intake was high, but the sleep-time difference remained highly significant also for the non- and low-consumption (≤2 units per day) subgroup (n=121, 7.50h vs 8.42h, p=0.001). CONCLUSION: Epileptic seizures are often precipitated by a combination of various clinical factors, but sleep loss stands out as an independent seizure trigger.
PURPOSE: The relationship between sleep and seizures is intricate. The aim of this study was to assess whether sleep loss is an independent seizure precipitant in a clinical setting. METHODS: In this prospective, observational cross-over study, 179 consecutive hospital admissions for epileptic seizures were included. A semi-structured interview regarding several seizure precipitants was performed. The sleep pattern prior to the seizure, as well as alcohol, caffeine and drug use, were recorded. The interview was repeated by telephone covering the same weekday at a time when there had been no recent seizure. The Hospital Anxiety and Depression Scale (HADS) and a visual analogue scale for perceived stress were applied at admission. Student's t-test, Fisher exact test and ANOVA were used for statistical analyses. RESULTS: Complete data for analysis were retrieved in 144 patients. The sleep-time during the 24h prior to the seizure was lower (7.3h) compared to follow-up (8.3h; p<0.0005). Caffeine consumption and use of relevant non antiepileptic drugs (AED) were not different. HADS and stress scores at admission did not correlate with sleep-time difference. In ANOVA, controlled for alcohol consumption and AED use, the sleep-time difference remained significant (p=0.008). The interaction with alcohol intake was high, but the sleep-time difference remained highly significant also for the non- and low-consumption (≤2 units per day) subgroup (n=121, 7.50h vs 8.42h, p=0.001). CONCLUSION:Epileptic seizures are often precipitated by a combination of various clinical factors, but sleep loss stands out as an independent seizure trigger.
Authors: Daniel E Payne; Katrina L Dell; Phillipa J Karoly; Vaclav Kremen; Vaclav Gerla; Levin Kuhlmann; Gregory A Worrell; Mark J Cook; David B Grayden; Dean R Freestone Journal: Epilepsia Date: 2020-12-30 Impact factor: 6.740
Authors: Johanna A Forsgård; Liisa Metsähonkala; Anna-Mariam Kiviranta; Sigitas Cizinauskas; Jouni J T Junnila; Outi Laitinen-Vapaavuori; Tarja S Jokinen Journal: J Vet Intern Med Date: 2018-12-21 Impact factor: 3.333
Authors: Andrea Biondi; Petroula Laiou; Elisa Bruno; Pedro F Viana; Martijn Schreuder; William Hart; Ewan Nurse; Deb K Pal; Mark P Richardson Journal: JMIR Res Protoc Date: 2021-03-19
Authors: Katrina L Dell; Daniel E Payne; Vaclav Kremen; Matias I Maturana; Vaclav Gerla; Petr Nejedly; Gregory A Worrell; Lhotska Lenka; Filip Mivalt; Raymond C Boston; Benjamin H Brinkmann; Wendyl D'Souza; Anthony N Burkitt; David B Grayden; Levin Kuhlmann; Dean R Freestone; Mark J Cook Journal: EClinicalMedicine Date: 2021-06-05
Authors: Michael W Watkins; Ekta G Shah; Michael E Funke; Stephanie Garcia-Tarodo; Manish N Shah; Nitin Tandon; Fernando Maestu; Christopher Laohathai; David I Sandberg; Jeremy Lankford; Stephen Thompson; John Mosher; Gretchen Von Allmen Journal: Front Hum Neurosci Date: 2021-06-04 Impact factor: 3.169