Christel M Middeldorp1, Anke R Hammerschlag1, Klaasjan G Ouwens1, Maria M Groen-Blokhuis1, Beate St Pourcain1, Corina U Greven1, Irene Pappa1, Carla M T Tiesler1, Wei Ang1, Ilja M Nolte1, Natalia Vilor-Tejedor1, Jonas Bacelis1, Jane L Ebejer1, Huiying Zhao1, Gareth E Davies1, Erik A Ehli1, David M Evans1, Iryna O Fedko1, Mònica Guxens1, Jouke-Jan Hottenga1, James J Hudziak1, Astanand Jugessur1, John P Kemp1, Eva Krapohl1, Nicholas G Martin1, Mario Murcia1, Ronny Myhre1, Johan Ormel1, Susan M Ring1, Marie Standl1, Evie Stergiakouli1, Camilla Stoltenberg1, Elisabeth Thiering1, Nicholas J Timpson1, Maciej Trzaskowski1, Peter J van der Most1, Carol Wang1, Dale R Nyholt1, Sarah E Medland1, Benjamin Neale1, Bo Jacobsson1, Jordi Sunyer1, Catharina A Hartman1, Andrew J O Whitehouse1, Craig E Pennell1, Joachim Heinrich1, Robert Plomin1, George Davey Smith1, Henning Tiemeier1, Danielle Posthuma1, Dorret I Boomsma1. 1. Dr. Middeldorp is with Biological Psychology, Neuroscience Campus Amsterdam, VU University Amsterdam, and GGZinGeest/ VU University Medical Center, Amsterdam. Ms. Hammerschlag is with the Generation R Study Group, Erasmus MC Rotterdam, the Netherlands, and Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam. Mr. Ouwens and Dr. Groen-Blokhuis are with Biological Psychology, VU University Amsterdam, and the EMGO+ Institute for Health and Care Research, VU University Medical Center. Dr. St. Pourcain is with MRC Integrative Epidemiology Unit (MRC IEU), University of Bristol, UK, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands, and School of Experimental Psychology, University of Bristol. Dr. Greven is with Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Karakter, Child and Adolescent Psychiatry University Center, Radboud University Nijmegen, and MRC Social Genetic and Developmental Psychiatry Centre, King's College London. Dr. Pappa is with Generation R Study Group, and Pedagogical and Education Science, Erasmus University Rotterdam, The Netherlands. Drs. Tiesler and Thiering are with Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany and the Division of Metabolic and Nutritional Medicine, Munich, and Dr. von Hauner Children's Hospital, University of Munich Medical Center, Germany. Mr. Ang, Ms. Wang, and Dr. Pennell are with School of Women's and Infants' Health, University of Western Australia, Perth. Dr. Nolte is with University of Groningen, University Medical Center Groningen, The Netherlands. Ms. Vilor-Tejedor is with Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Universitat Pompeu Fabra (UPF), Barcelona, and CIBER Epidemiology and Public Health (CIBERESP), Madrid. Mr. Bacelis is with Gothenburg University, Sweden. Drs. Ebejer, Martin, and Medland are with QIMR Berghofer Medical Research Institute, Brisbane, Australia. Drs. Zhao and Nyholt are with Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. Drs. Davies and Ehli are with Avera Institute for Human Genetics, SD. Drs. Evans, Kemp, and Ring are with MRC IEU, School of Social and Community Medicine, and School of Social and Community Medicine, University of Bristol, and Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane. Ms. Fedko is with Biological Psychology, VU University Amsterdam. Dr. Guxens is with CREAL, UPF, CIBERESP, and Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center-Sophia Children´s Hospital, The Netherlands. Dr. Hottenga is with Biological Psychology, VU University, and EMGO+ Institute for Health and Care Research, VU University Medical Center. Dr. Hudziak is with Vermont Center for Children, Youth and Families and College of Medicine, University of Vermont, Burlington, and Child and Adolescent Psychiatry, Erasmus Medical Center. Drs. Jugessur, Myhre, and Stoltenberg are with the Norwegian Institute of Public Health, Oslo. Ms. Krapohl and Drs. Trzaskowski and Plomin are with MRC Social, Genetic and Developmental Psychiatry Centre, King's College London. Mr. Murcia is with CIBERESP, and FISABIO-Universitat Jaume I-Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain. Drs. Ormel and Hartman are with the Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen. Drs. Standl and Heinrich are with Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. Drs. Stergiakouli and Timpson are with MRC IEU; Dr. Timpson is also with School of Social and Community Medicine, University of Bristol. Dr. van der Most is with University of Groningen and University Medical Center Groningen. Dr. Neale is with Program in Medical and Population Genetics and Stanley Center for Psychiatric Genetics, Broad Institute of Massachusetts Institute of Technology, Boston, Analytic and Translation Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, and Harvard University, Cambridge, MA. Dr. Jacobsson is with Obstetrics and Gynecology, Gothenburg University, and the Norwegian Institute of Public Health. Dr. Sunyer is with CREAL, IMIM (Hospital del Mar Medical Research Institute), Barcelona, UPF, and CIBERESP. Dr. Whitehouse is with Telethon Kids Institute, University of Western Australia, Perth. Dr. Davey Smith is with MRC IEU, and School of Social and Community Medicine. Dr. Tiemeier is with Epidemiology, Child and Adolescent Psychiatry, and Psychiatry, Erasmus Medical Center. Dr. Posthuma is with the Generation R Study Group, Erasmus MC Rotterdam, the Netherlands, Child and Adolescent Psychiatry, Erasmus Medical Center, Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, and Clinical Genetics, VU University Medical Center. Dr. Boomsma is with Biological Psychology, VU University, Neuroscience Campus Amsterdam, VU University, and EMGO+ Institute for Health and Care Research, VU University Medical Center.
Abstract
OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests, and the overlap in results with a meta-analysis in the Psychiatric Genomics Consortium (PGC) case-control ADHD study was investigated. RESULTS: SNP-based heritability ranged from 5% to 34%, indicating that variation in common genetic variants influences ADHD symptom scores. The meta-analysis did not detect genome-wide significant SNPs, but three genes, lying close to each other with SNPs in high linkage disequilibrium (LD), showed a gene-wide significant association (p values between 1.46 × 10(-6) and 2.66 × 10(-6)). One gene, WASL, is involved in neuronal development. Both SNP- and gene-based analyses indicated overlap with the PGC meta-analysis results with the genetic correlation estimated at 0.96. CONCLUSION: The SNP-based heritability for ADHD symptom scores indicates a polygenic architecture, and genes involved in neurite outgrowth are possibly involved. Continuous and dichotomous measures of ADHD appear to assess a genetically common phenotype. A next step is to combine data from population-based and case-control cohorts in genetic association studies to increase sample size and to improve statistical power for identifying genetic variants.
OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests, and the overlap in results with a meta-analysis in the Psychiatric Genomics Consortium (PGC) case-control ADHD study was investigated. RESULTS: SNP-based heritability ranged from 5% to 34%, indicating that variation in common genetic variants influences ADHD symptom scores. The meta-analysis did not detect genome-wide significant SNPs, but three genes, lying close to each other with SNPs in high linkage disequilibrium (LD), showed a gene-wide significant association (p values between 1.46 × 10(-6) and 2.66 × 10(-6)). One gene, WASL, is involved in neuronal development. Both SNP- and gene-based analyses indicated overlap with the PGC meta-analysis results with the genetic correlation estimated at 0.96. CONCLUSION: The SNP-based heritability for ADHD symptom scores indicates a polygenic architecture, and genes involved in neurite outgrowth are possibly involved. Continuous and dichotomous measures of ADHD appear to assess a genetically common phenotype. A next step is to combine data from population-based and case-control cohorts in genetic association studies to increase sample size and to improve statistical power for identifying genetic variants.
Authors: Maria M Groen-Blokhuis; Christel M Middeldorp; Kees-Jan Kan; Abdel Abdellaoui; Catharina E M van Beijsterveldt; Erik A Ehli; Gareth E Davies; Paul A Scheet; Xiangjun Xiao; James J Hudziak; Jouke-Jan Hottenga; Ben M Neale; Dorret I Boomsma Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-08-19 Impact factor: 8.829
Authors: Andy Boyd; Jean Golding; John Macleod; Debbie A Lawlor; Abigail Fraser; John Henderson; Lynn Molloy; Andy Ness; Susan Ring; George Davey Smith Journal: Int J Epidemiol Date: 2012-04-16 Impact factor: 7.196
Authors: Iryna O Fedko; Jouke-Jan Hottenga; Carolina Medina-Gomez; Irene Pappa; Catharina E M van Beijsterveldt; Erik A Ehli; Gareth E Davies; Fernando Rivadeneira; Henning Tiemeier; Morris A Swertz; Christel M Middeldorp; Meike Bartels; Dorret I Boomsma Journal: Behav Genet Date: 2015-06-03 Impact factor: 2.805
Authors: S Hong Lee; Stephan Ripke; Benjamin M Neale; Stephen V Faraone; Shaun M Purcell; Roy H Perlis; Bryan J Mowry; Anita Thapar; Michael E Goddard; John S Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E Arking; Philip Asherson; Maria H Azevedo; Lena Backlund; Judith A Badner; Anthony J Bailey; Tobias Banaschewski; Jack D Barchas; Michael R Barnes; Thomas B Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah E Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B Binder; Donald W Black; Douglas H R Blackwood; Cinnamon S Bloss; Michael Boehnke; Dorret I Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy G Buccola; Jan K Buitelaar; William E Bunney; Joseph D Buxbaum; William F Byerley; Enda M Byrne; Sian Caesar; Wiepke Cahn; Rita M Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; C Robert Cloninger; David A Collier; Edwin H Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H Coryell; David W Craig; Ian W Craig; Jennifer Crosbie; Michael L Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J Donohoe; Alysa E Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P Ebstein; Howard J Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B Freimer; Christine M Freitag; Marion Friedl; Louise Frisén; Louise Gallagher; Pablo V Gejman; Lyudmila Georgieva; Elliot S Gershon; Daniel H Geschwind; Ina Giegling; Michael Gill; Scott D Gordon; Katherine Gordon-Smith; Elaine K Green; Tiffany A Greenwood; Dorothy E Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P Hamilton; Marian L Hamshere; Thomas F Hansen; Annette M Hartmann; Martin Hautzinger; Andrew C Heath; Anjali K Henders; Stefan Herms; Ian B Hickie; Maria Hipolito; Susanne Hoefels; Peter A Holmans; Florian Holsboer; Witte J Hoogendijk; Jouke-Jan Hottenga; Christina M Hultman; Vanessa Hus; Andrés Ingason; Marcus Ising; Stéphane Jamain; Edward G Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K Kähler; René S Kahn; Radhika Kandaswamy; Matthew C Keller; James L Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K Kirov; Sabine M Klauck; Lambertus Klei; James A Knowles; Martin A Kohli; Daniel L Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landén; Niklas Långström; Mark Lathrop; Jacob Lawrence; William B Lawson; Marion Leboyer; David H Ledbetter; Phil H Lee; Todd Lencz; Klaus-Peter Lesch; Douglas F Levinson; Cathryn M Lewis; Jun Li; Paul Lichtenstein; Jeffrey A Lieberman; Dan-Yu Lin; Don H Linszen; Chunyu Liu; Falk W Lohoff; Sandra K Loo; Catherine Lord; Jennifer K Lowe; Susanne Lucae; Donald J MacIntyre; Pamela A F Madden; Elena Maestrini; Patrik K E Magnusson; Pamela B Mahon; Wolfgang Maier; Anil K Malhotra; Shrikant M Mane; Christa L Martin; Nicholas G Martin; Manuel Mattheisen; Keith Matthews; Morten Mattingsdal; Steven A McCarroll; Kevin A McGhee; James J McGough; Patrick J McGrath; Peter McGuffin; Melvin G McInnis; Andrew McIntosh; Rebecca McKinney; Alan W McLean; Francis J McMahon; William M McMahon; Andrew McQuillin; Helena Medeiros; Sarah E Medland; Sandra Meier; Ingrid Melle; Fan Meng; Jobst Meyer; Christel M Middeldorp; Lefkos Middleton; Vihra Milanova; Ana Miranda; Anthony P Monaco; Grant W Montgomery; Jennifer L Moran; Daniel Moreno-De-Luca; Gunnar Morken; Derek W Morris; Eric M Morrow; Valentina Moskvina; Pierandrea Muglia; Thomas W Mühleisen; Walter J Muir; Bertram Müller-Myhsok; Michael Murtha; Richard M Myers; Inez Myin-Germeys; Michael C Neale; Stan F Nelson; Caroline M Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A Nolen; Markus M Nöthen; John I Nurnberger; Evaristus A Nwulia; Dale R Nyholt; Colm O'Dushlaine; Robert D Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A Ophoff; Urban Osby; Michael J Owen; Aarno Palotie; Jeremy R Parr; Andrew D Paterson; Carlos N Pato; Michele T Pato; Brenda W Penninx; Michele L Pergadia; Margaret A Pericak-Vance; Benjamin S Pickard; Jonathan Pimm; Joseph Piven; Danielle Posthuma; James B Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J Quested; Emma M Quinn; Josep Antoni Ramos-Quiroga; Henrik B Rasmussen; Soumya Raychaudhuri; Karola Rehnström; Andreas Reif; Marta Ribasés; John P Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Lizzy Rossin; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R Sanders; Stephan J Sanders; Susan L Santangelo; Joseph A Sergeant; Russell Schachar; Martin Schalling; Alan F Schatzberg; William A Scheftner; Gerard D Schellenberg; Stephen W Scherer; Nicholas J Schork; Thomas G Schulze; Johannes Schumacher; Markus Schwarz; Edward Scolnick; Laura J Scott; Jianxin Shi; Paul D Shilling; Stanley I Shyn; Jeremy M Silverman; Susan L Slager; Susan L Smalley; Johannes H Smit; Erin N Smith; Edmund J S Sonuga-Barke; David St Clair; Matthew State; Michael Steffens; Hans-Christoph Steinhausen; John S Strauss; Jana Strohmaier; T Scott Stroup; James S Sutcliffe; Peter Szatmari; Szabocls Szelinger; Srinivasa Thirumalai; Robert C Thompson; Alexandre A Todorov; Federica Tozzi; Jens Treutlein; Manfred Uhr; Edwin J C G van den Oord; Gerard Van Grootheest; Jim Van Os; Astrid M Vicente; Veronica J Vieland; John B Vincent; Peter M Visscher; Christopher A Walsh; Thomas H Wassink; Stanley J Watson; Myrna M Weissman; Thomas Werge; Thomas F Wienker; Ellen M Wijsman; Gonneke Willemsen; Nigel Williams; A Jeremy Willsey; Stephanie H Witt; Wei Xu; Allan H Young; Timothy W Yu; Stanley Zammit; Peter P Zandi; Peng Zhang; Frans G Zitman; Sebastian Zöllner; Bernie Devlin; John R Kelsoe; Pamela Sklar; Mark J Daly; Michael C O'Donovan; Nicholas Craddock; Patrick F Sullivan; Jordan W Smoller; Kenneth S Kendler; Naomi R Wray Journal: Nat Genet Date: 2013-08-11 Impact factor: 38.330
Authors: Li Yang; Benjamin M Neale; Lu Liu; S Hong Lee; Naomi R Wray; Ning Ji; Haimei Li; Qiujin Qian; Dongliang Wang; Jun Li; Stephen V Faraone; Yufeng Wang Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2013-05-31 Impact factor: 3.568
Authors: Stéphanie M van den Berg; Marleen H M de Moor; Karin J H Verweij; Robert F Krueger; Michelle Luciano; Alejandro Arias Vasquez; Lindsay K Matteson; Jaime Derringer; Tõnu Esko; Najaf Amin; Scott D Gordon; Narelle K Hansell; Amy B Hart; Ilkka Seppälä; Jennifer E Huffman; Bettina Konte; Jari Lahti; Minyoung Lee; Mike Miller; Teresa Nutile; Toshiko Tanaka; Alexander Teumer; Alexander Viktorin; Juho Wedenoja; Abdel Abdellaoui; Goncalo R Abecasis; Daniel E Adkins; Arpana Agrawal; Jüri Allik; Katja Appel; Timothy B Bigdeli; Fabio Busonero; Harry Campbell; Paul T Costa; George Davey Smith; Gail Davies; Harriet de Wit; Jun Ding; Barbara E Engelhardt; Johan G Eriksson; Iryna O Fedko; Luigi Ferrucci; Barbara Franke; Ina Giegling; Richard Grucza; Annette M Hartmann; Andrew C Heath; Kati Heinonen; Anjali K Henders; Georg Homuth; Jouke-Jan Hottenga; William G Iacono; Joost Janzing; Markus Jokela; Robert Karlsson; John P Kemp; Matthew G Kirkpatrick; Antti Latvala; Terho Lehtimäki; David C Liewald; Pamela A F Madden; Chiara Magri; Patrik K E Magnusson; Jonathan Marten; Andrea Maschio; Hamdi Mbarek; Sarah E Medland; Evelin Mihailov; Yuri Milaneschi; Grant W Montgomery; Matthias Nauck; Michel G Nivard; Klaasjan G Ouwens; Aarno Palotie; Erik Pettersson; Ozren Polasek; Yong Qian; Laura Pulkki-Råback; Olli T Raitakari; Anu Realo; Richard J Rose; Daniela Ruggiero; Carsten O Schmidt; Wendy S Slutske; Rossella Sorice; John M Starr; Beate St Pourcain; Angelina R Sutin; Nicholas J Timpson; Holly Trochet; Sita Vermeulen; Eero Vuoksimaa; Elisabeth Widen; Jasper Wouda; Margaret J Wright; Lina Zgaga; David Porteous; Alessandra Minelli; Abraham A Palmer; Dan Rujescu; Marina Ciullo; Caroline Hayward; Igor Rudan; Andres Metspalu; Jaakko Kaprio; Ian J Deary; Katri Räikkönen; James F Wilson; Liisa Keltikangas-Järvinen; Laura J Bierut; John M Hettema; Hans J Grabe; Brenda W J H Penninx; Cornelia M van Duijn; David M Evans; David Schlessinger; Nancy L Pedersen; Antonio Terracciano; Matt McGue; Nicholas G Martin; Dorret I Boomsma Journal: Behav Genet Date: 2015-09-11 Impact factor: 2.805
Authors: Julia E Morgan; Barbara Caplan; Irene Tung; Amanda N Noroña; Bruce L Baker; Steve S Lee Journal: Child Neuropsychol Date: 2017-07-04 Impact factor: 2.500
Authors: Daniel Seung Kim; Amber A Burt; Jane E Ranchalis; Beth Wilmot; Joshua D Smith; Karynne E Patterson; Bradley P Coe; Yatong K Li; Michael J Bamshad; Molly Nikolas; Evan E Eichler; James M Swanson; Joel T Nigg; Deborah A Nickerson; Gail P Jarvik Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-03-22 Impact factor: 3.568
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Authors: Martine Hoogman; Ryan Muetzel; Joao P Guimaraes; Elena Shumskaya; Maarten Mennes; Marcel P Zwiers; Neda Jahanshad; Gustavo Sudre; Thomas Wolfers; Eric A Earl; Juan Carlos Soliva Vila; Yolanda Vives-Gilabert; Sabin Khadka; Stephanie E Novotny; Catharina A Hartman; Dirk J Heslenfeld; Lizanne J S Schweren; Sara Ambrosino; Bob Oranje; Patrick de Zeeuw; Tiffany M Chaim-Avancini; Pedro G P Rosa; Marcus V Zanetti; Charles B Malpas; Gregor Kohls; Georg G von Polier; Jochen Seitz; Joseph Biederman; Alysa E Doyle; Anders M Dale; Theo G M van Erp; Jeffery N Epstein; Terry L Jernigan; Ramona Baur-Streubel; Georg C Ziegler; Kathrin C Zierhut; Anouk Schrantee; Marie F Høvik; Astri J Lundervold; Clare Kelly; Hazel McCarthy; Norbert Skokauskas; Ruth L O'Gorman Tuura; Anna Calvo; Sara Lera-Miguel; Rosa Nicolau; Kaylita C Chantiluke; Anastasia Christakou; Alasdair Vance; Mara Cercignani; Matt C Gabel; Philip Asherson; Sarah Baumeister; Daniel Brandeis; Sarah Hohmann; Ivanei E Bramati; Fernanda Tovar-Moll; Andreas J Fallgatter; Bernd Kardatzki; Lena Schwarz; Anatoly Anikin; Alexandr Baranov; Tinatin Gogberashvili; Dmitry Kapilushniy; Anastasia Solovieva; Hanan El Marroun; Tonya White; Georgii Karkashadze; Leyla Namazova-Baranova; Thomas Ethofer; Paulo Mattos; Tobias Banaschewski; David Coghill; Kerstin J Plessen; Jonna Kuntsi; Mitul A Mehta; Yannis Paloyelis; Neil A Harrison; Mark A Bellgrove; Tim J Silk; Ana I Cubillo; Katya Rubia; Luisa Lazaro; Silvia Brem; Susanne Walitza; Thomas Frodl; Mariam Zentis; Francisco X Castellanos; Yuliya N Yoncheva; Jan Haavik; Liesbeth Reneman; Annette Conzelmann; Klaus-Peter Lesch; Paul Pauli; Andreas Reif; Leanne Tamm; Kerstin Konrad; Eileen Oberwelland Weiss; Geraldo F Busatto; Mario R Louza; Sarah Durston; Pieter J Hoekstra; Jaap Oosterlaan; Michael C Stevens; J Antoni Ramos-Quiroga; Oscar Vilarroya; Damien A Fair; Joel T Nigg; Paul M Thompson; Jan K Buitelaar; Stephen V Faraone; Philip Shaw; Henning Tiemeier; Janita Bralten; Barbara Franke Journal: Am J Psychiatry Date: 2019-04-24 Impact factor: 18.112
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Authors: Ditte Demontis; Raymond K Walters; Joanna Martin; Manuel Mattheisen; Thomas D Als; Esben Agerbo; Gísli Baldursson; Rich Belliveau; Jonas Bybjerg-Grauholm; Marie Bækvad-Hansen; Felecia Cerrato; Kimberly Chambert; Claire Churchhouse; Ashley Dumont; Nicholas Eriksson; Michael Gandal; Jacqueline I Goldstein; Katrina L Grasby; Jakob Grove; Olafur O Gudmundsson; Christine S Hansen; Mads Engel Hauberg; Mads V Hollegaard; Daniel P Howrigan; Hailiang Huang; Julian B Maller; Alicia R Martin; Nicholas G Martin; Jennifer Moran; Jonatan Pallesen; Duncan S Palmer; Carsten Bøcker Pedersen; Marianne Giørtz Pedersen; Timothy Poterba; Jesper Buchhave Poulsen; Stephan Ripke; Elise B Robinson; F Kyle Satterstrom; Hreinn Stefansson; Christine Stevens; Patrick Turley; G Bragi Walters; Hyejung Won; Margaret J Wright; Ole A Andreassen; Philip Asherson; Christie L Burton; Dorret I Boomsma; Bru Cormand; Søren Dalsgaard; Barbara Franke; Joel Gelernter; Daniel Geschwind; Hakon Hakonarson; Jan Haavik; Henry R Kranzler; Jonna Kuntsi; Kate Langley; Klaus-Peter Lesch; Christel Middeldorp; Andreas Reif; Luis Augusto Rohde; Panos Roussos; Russell Schachar; Pamela Sklar; Edmund J S Sonuga-Barke; Patrick F Sullivan; Anita Thapar; Joyce Y Tung; Irwin D Waldman; Sarah E Medland; Kari Stefansson; Merete Nordentoft; David M Hougaard; Thomas Werge; Ole Mors; Preben Bo Mortensen; Mark J Daly; Stephen V Faraone; Anders D Børglum; Benjamin M Neale Journal: Nat Genet Date: 2018-11-26 Impact factor: 38.330