Literature DB >> 2766028

Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA).

A R Malcolm1, L J Mills.   

Abstract

Di(2-ethylhexyl)phthalate and trisodium nitrilotriacetate monohydrate, two apparently nongenotoxic carcinogens, were tested for effects on gap-junctional communication between Chinese hamster V79 lung fibroblasts. Both compounds inhibited gap-junctional communication in a concentration-dependent manner. The inhibiting effects of these chemicals on gap-junctional communication in vitro correlate with their tumor-promoting activity. Such results further support the hypothesis that inhibition of gap-junctional communication is an in vitro biomarker for some tumor-promoting chemicals.

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Year:  1989        PMID： 2766028     DOI： 10.1007/BF00122649

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  30 in total

1.  Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

Authors:  L P Yotti; C C Chang; J E Trosko
Journal:  Science       Date:  1979-11-30       Impact factor: 47.728

Review 2.  A review of the environmental and mammalian toxicology of nitrilotriacetic acid.

Authors:  R L Anderson; W E Bishop; R L Campbell
Journal:  Crit Rev Toxicol       Date:  1985       Impact factor: 5.635

3.  Mutagenicity testing of di(2-ethylhexyl)phthalate and related chemicals in Salmonella.

Authors:  E Zeiger; S Haworth; K Mortelmans; W Speck
Journal:  Environ Mutagen       Date:  1985

4.  Limiting factors of the V79 cell metabolic cooperation assay for tumor promoters.

Authors:  B H Dorman; C J Boreiko
Journal:  Carcinogenesis       Date:  1983       Impact factor: 4.944

5.  Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.

Authors:  J M Ward; J M Rice; D Creasia; P Lynch; C Riggs
Journal:  Carcinogenesis       Date:  1983-08       Impact factor: 4.944

6.  Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.

Authors:  G M Williams; H Maruyama; T Tanaka
Journal:  Carcinogenesis       Date:  1987-07       Impact factor: 4.944

7.  Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl)phthalate.

Authors:  J A Popp; L K Garvey; T E Hamm; J A Swenberg
Journal:  Carcinogenesis       Date:  1985-01       Impact factor: 4.944

8.  Evaluation of di-(2-ethylhexyl)phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay.

Authors:  P E Kirby; R F Pizzarello; T E Lawlor; S R Haworth; J R Hodgson
Journal:  Environ Mutagen       Date:  1983

9.  The implications of trace metal-nitrilotriacetetic acid speciation on its environmental impact and toxicology.

Authors:  M Rubin; A E Martell
Journal:  Biol Trace Elem Res       Date:  1980-03       Impact factor: 3.738

10.  Mutagenic/carcinogenic potential of DEHP and MEHP.

Authors:  I Tomita; Y Nakamura; N Aoki; N Inui
Journal:  Environ Health Perspect       Date:  1982-11       Impact factor: 9.031
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  1 in total

Review 1.  Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.

Authors:  I V Budunova; G M Williams
Journal:  Cell Biol Toxicol       Date:  1994-04       Impact factor: 6.691
  1 in total

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