Luca Mattei1, Francesco Prada2, Federico Giuseppe Legnani2, Alessandro Perin2, Alessandro Olivi3, Francesco DiMeco2,4. 1. Neurochirurgia I, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Giovanni Celoria 11, 20133, Milan, Italy. luca.mattei@fastwebnet.it. 2. Neurochirurgia I, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Giovanni Celoria 11, 20133, Milan, Italy. 3. Istituto di Neurochirurgia, Fondazione Policlinico Universitario "A. Gemelli" Università Cattolica e del Sacro Cuore, Largo A. Gemelli 8, 00186, Rome, Italy. 4. Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, 21218, USA.
Abstract
PURPOSE: Pediatric low-grade gliomas (LGGs) are the most frequent solid tumor in childhood. Based on an increasing number of literature reports, maximal safe resection is recommended as the first line of treatment whenever possible. However, distinguishing tumor tissue from the surrounding normal brain is often challenging with infiltrating neoplasms, even with the assistance of intraoperative, microscopic and conventional neuronavigation systems. Therefore, any technique that enhances the detection and visualization of LGGs intraoperatively is certainly desirable. METHODS: In this paper, we reviewed the role of intraoperative conventional ultrasound and contrast-enhanced ultrasound (CEUS) as a tool for extending tumor resection in LGGs. Moreover, our experience with this technology is reported and discussed. RESULTS: Both B-mode and CEUS are helpful in highlighting LGGs, detecting tumor margins and providing additional information such as vascularization, thus improving the safety of a more radical resection. CONCLUSIONS: Although the full potentialities of the method are yet to be explored, intraoperative ultrasound is a promising tool in oncologic surgery and LGG surgery.
PURPOSE: Pediatric low-grade gliomas (LGGs) are the most frequent solid tumor in childhood. Based on an increasing number of literature reports, maximal safe resection is recommended as the first line of treatment whenever possible. However, distinguishing tumor tissue from the surrounding normal brain is often challenging with infiltrating neoplasms, even with the assistance of intraoperative, microscopic and conventional neuronavigation systems. Therefore, any technique that enhances the detection and visualization of LGGs intraoperatively is certainly desirable. METHODS: In this paper, we reviewed the role of intraoperative conventional ultrasound and contrast-enhanced ultrasound (CEUS) as a tool for extending tumor resection in LGGs. Moreover, our experience with this technology is reported and discussed. RESULTS: Both B-mode and CEUS are helpful in highlighting LGGs, detecting tumor margins and providing additional information such as vascularization, thus improving the safety of a more radical resection. CONCLUSIONS: Although the full potentialities of the method are yet to be explored, intraoperative ultrasound is a promising tool in oncologic surgery and LGG surgery.
Authors: F Piscaglia; C Nolsøe; C F Dietrich; D O Cosgrove; O H Gilja; M Bachmann Nielsen; T Albrecht; L Barozzi; M Bertolotto; O Catalano; M Claudon; D A Clevert; J M Correas; M D'Onofrio; F M Drudi; J Eyding; M Giovannini; M Hocke; A Ignee; E M Jung; A S Klauser; N Lassau; E Leen; G Mathis; A Saftoiu; G Seidel; P S Sidhu; G ter Haar; D Timmerman; H P Weskott Journal: Ultraschall Med Date: 2011-08-26 Impact factor: 6.548
Authors: Mustafa Aziz Hatiboglu; Jeffrey S Weinberg; Dima Suki; Ganesh Rao; Sujit S Prabhu; Komal Shah; Ed Jackson; Raymond Sawaya Journal: Neurosurgery Date: 2009-06 Impact factor: 4.654