Literature DB >> 27652330

NBR2: A former junk gene emerges as a key player in tumor suppression.

Zhen-Dong Xiao1, Xiaowen Liu1, Li Zhuang1, Boyi Gan1.   

Abstract

NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.

Entities:  

Keywords:  AMPK; BRCA1; NBR2; energy stress response; lncRNA; tumor suppression

Year:  2016        PMID： 27652330      PMCID： PMC4972102          DOI： 10.1080/23723556.2016.1187322

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Authors:  Vladimir Kirkin; Trond Lamark; Yu-Shin Sou; Geir Bjørkøy; Jennifer L Nunn; Jack-Ansgar Bruun; Elena Shvets; David G McEwan; Terje H Clausen; Philipp Wild; Ivana Bilusic; Jean-Philippe Theurillat; Aud Øvervatn; Tetsuro Ishii; Zvulun Elazar; Masaaki Komatsu; Ivan Dikic; Terje Johansen
Journal:  Mol Cell       Date:  2009-02-27       Impact factor: 17.970

Review 2.  AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Authors:  D Grahame Hardie; Fiona A Ross; Simon A Hawley
Journal:  Nat Rev Mol Cell Biol       Date:  2012-03-22       Impact factor: 94.444

3.  Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene.

Authors:  C F Xu; M A Brown; H Nicolai; J A Chambers; B L Griffiths; E Solomon
Journal:  Hum Mol Genet       Date:  1997-07       Impact factor: 6.150

Review 4.  lincRNAs: genomics, evolution, and mechanisms.

Authors:  Igor Ulitsky; David P Bartel
Journal:  Cell       Date:  2013-07-03       Impact factor: 41.582

5.  Complex regulation of the BRCA1 gene.

Authors:  C F Xu; J A Chambers; E Solomon
Journal:  J Biol Chem       Date:  1997-08-22       Impact factor: 5.157

6.  Deletion of exons 1a-2 of BRCA1: a rather frequent pathogenic abnormality.

Authors:  Ans M W van den Ouweland; Winand N M Dinjens; Lambert C J Dorssers; Monique M van Veghel-Plandsoen; Hennie T Brüggenwirth; Caroline J Withagen-Hermans; Johanna Margriet Collée; Simon A Joosse; Joan N R Terlouw-Kromosoeto; Petra M Nederlof
Journal:  Genet Test Mol Biomarkers       Date:  2009-06

7.  Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells.

Authors:  Sai Luo; J Yuyang Lu; Lichao Liu; Yafei Yin; Chunyan Chen; Xue Han; Bohou Wu; Ronggang Xu; Wei Liu; Pixi Yan; Wen Shao; Zhi Lu; Haitao Li; Jie Na; Fuchou Tang; Jianlong Wang; Yong E Zhang; Xiaohua Shen
Journal:  Cell Stem Cell       Date:  2016-03-17       Impact factor: 24.633

8.  A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer.

Authors:  Zaida Garcia-Casado; Ignacio Romero; Antonio Fernandez-Serra; Luis Rubio; Francisco Llopis; Ana Garcia; Pilar Llombart; Jose A Lopez-Guerrero
Journal:  BMC Med Genet       Date:  2011-10-11       Impact factor: 2.103

9.  Structural evolution of the BRCA1 genomic region in primates.

Authors:  Hong Jin; Joanna Selfe; Caroline Whitehouse; Joanna R Morris; Ellen Solomon; Roland G Roberts
Journal:  Genomics       Date:  2004-12       Impact factor: 5.736

10.  LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress.

Authors:  Xiaowen Liu; Zhen-Dong Xiao; Leng Han; Jiexin Zhang; Szu-Wei Lee; Wenqi Wang; Hyemin Lee; Li Zhuang; Junjie Chen; Hui-Kuan Lin; Jing Wang; Han Liang; Boyi Gan
Journal:  Nat Cell Biol       Date:  2016-03-21       Impact factor: 28.824
  10 in total
  11 in total

1.  lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1.

Authors:  Xiaowen Liu; Boyi Gan
Journal:  Cell Cycle       Date:  2016-10-28       Impact factor: 4.534

Review 2.  Long non-coding RNAs in cancer metabolism.

Authors:  Zhen-Dong Xiao; Li Zhuang; Boyi Gan
Journal:  Bioessays       Date:  2016-08-23       Impact factor: 4.345

Review 3.  Role of long non-coding RNAs in glucose metabolism in cancer.

Authors:  Chunmei Fan; Yanyan Tang; Jinpeng Wang; Fang Xiong; Can Guo; Yumin Wang; Shanshan Zhang; Zhaojian Gong; Fang Wei; Liting Yang; Yi He; Ming Zhou; Xiaoling Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng
Journal:  Mol Cancer       Date:  2017-07-24       Impact factor: 27.401

4.  Complex Characterization of Germline Large Genomic Rearrangements of the BRCA1 and BRCA2 Genes in High-Risk Breast Cancer Patients-Novel Variants from a Large National Center.

Authors:  Anikó Bozsik; Tímea Pócza; János Papp; Tibor Vaszkó; Henriett Butz; Attila Patócs; Edit Oláh
Journal:  Int J Mol Sci       Date:  2020-06-30       Impact factor: 5.923

Review 5.  Emerging roles of long non-coding RNAs in tumor metabolism.

Authors:  Hui Sun; Zhaohui Huang; Weiqi Sheng; Mi-Die Xu
Journal:  J Hematol Oncol       Date:  2018-08-22       Impact factor: 17.388

Review 6.  Long Non-Coding RNA Neighbor of BRCA1 Gene 2: A Crucial Regulator in Cancer Biology.

Authors:  Ting Wang; Zhaosheng Li; Liujia Yan; Feng Yan; Han Shen; Xinyu Tian
Journal:  Front Oncol       Date:  2021-12-02       Impact factor: 6.244

Review 7.  Long non-coding RNAs involved in autophagy regulation.

Authors:  Lixian Yang; Hanying Wang; Qi Shen; Lifeng Feng; Hongchuan Jin
Journal:  Cell Death Dis       Date:  2017-10-05       Impact factor: 8.469

8.  Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway.

Authors:  Hua Yu; Yangyang Xie; Zhendong Zhou; Zhou Wu; Xiaoyu Dai; Binbin Xu
Journal:  Technol Cancer Res Treat       Date:  2019 Jan-Dec

9.  STIM2 interacts with AMPK and regulates calcium-induced AMPK activation.

Authors:  Anoop Singh Chauhan; Xiaoguang Liu; Ji Jing; Hyemin Lee; Raj Kumar Yadav; Jindou Liu; Yubin Zhou; Boyi Gan
Journal:  FASEB J       Date:  2018-10-18       Impact factor: 5.191

10.  LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1.

Authors:  Stella Logotheti; Stephan Marquardt; Shailendra K Gupta; Christin Richter; Berdien A H Edelhäuser; David Engelmann; Julia Brenmoehl; Christoph Söhnchen; Nico Murr; Michael Alpers; Krishna P Singh; Olaf Wolkenhauer; Dirk Heckl; Alf Spitschak; Brigitte M Pützer
Journal:  Theranostics       Date:  2020-07-29       Impact factor: 11.556
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