Literature DB >> 9261099

Complex regulation of the BRCA1 gene.

C F Xu1, J A Chambers, E Solomon.   

Abstract

We have analyzed the promoter region of the human BRCA1 gene in detail and demonstrate that the expression of the BRCA1 gene is under complex regulation. First, its transcription is under the control of two promoters generating two distinct transcripts alpha and beta, and second, promoter alpha is shared with the adjacent NBR2 gene and is bi-directional. Both promoter alpha and promoter beta are responsive to estrogen stimulation. We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9261099     DOI： 10.1074/jbc.272.34.20994

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  52 in total

Review 1.  Expression of BRCA1 and BRCA2 in normal and neoplastic cells.

Authors:  L A Chodosh
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-10       Impact factor: 2.673

2.  Evidence for effective suppression of recombination in the chromosome 17q21 segment spanning RNU2-BRCA1.

Authors:  X Liu; D F Barker
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

3.  Identification and characterization of a transcriptional silencer upstream of the human BRCA2 gene.

Authors:  C Sharan; N M Hamilton; A K Parl; P K Singh; G Chaudhuri
Journal:  Biochem Biophys Res Commun       Date:  1999-11-19       Impact factor: 3.575

Review 4.  Emerging roles of BRCA1 alternative splicing.

Authors:  T I Orban; E Olah
Journal:  Mol Pathol       Date:  2003-08

5.  Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.

Authors:  Ee Ming Wong; Melissa C Southey; Stephen B Fox; Melissa A Brown; James G Dowty; Mark A Jenkins; Graham G Giles; John L Hopper; Alexander Dobrovic
Journal:  Cancer Prev Res (Phila)       Date:  2010-10-26

6.  Influence of estrogen and variations at the BRCA1 promoter region on transcription and translation.

Authors:  Lívia R Fernandes; Emmerson C B Costa; Fernando R Vargas; Miguel A M Moreira
Journal:  Mol Biol Rep       Date:  2013-12-01       Impact factor: 2.316

7.  Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women.

Authors:  K Y-K Chan; W Liu; J-R Long; S-P Yip; S-Y Chan; X-O Shu; D T-T Chua; A N-Y Cheung; J C-Y Ching; H Cai; G K-H Au; M Chan; W Foo; H Y-S Ngan; Y-T Gao; E S-W Ngan; M-M Garcia-Barceló; Wei Zheng; U-S Khoo
Journal:  J Med Genet       Date:  2008-09-09       Impact factor: 6.318

8.  Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours.

Authors:  Azhar B Ali; Philip T C Iau; Jen-Hwei Sng
Journal:  Med Oncol       Date:  2010-02-05       Impact factor: 3.064

Review 9.  Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology.

Authors:  Kazuhiro Ikeda; Kuniko Horie-Inoue; Satoshi Inoue
Journal:  Acta Pharmacol Sin       Date:  2014-12-15       Impact factor: 6.150

10.  Orientation, distance, regulation and function of neighbouring genes.

Authors:  Adrian Gherman; Ruihua Wang; Dimitrios Avramopoulos
Journal:  Hum Genomics       Date:  2009-01       Impact factor: 4.639
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.