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Literature DB >> 2764707

An in vivo study of benzene metabolite DNA adduct formation in liver of male New Zealand rabbits.

Abstract

Rabbits were treated with benzene (586 mg/kg/b.i.d./4 days) after which DNA was isolated from liver and analyzed for adduct formation using the [32P] post-labeling method of Randerath and coworkers (Randerath et al. 1981; Reddy et al. 1984, 1986, 1987). Liver 500 g and 9000 g fractions were analyzed for adducts. There appeared to be several adducts in both the 500 g and 9000 g fractions observed on radioautographs of cellulose-TLC plates. Several adducts were also observed when the 9000 g fraction was studied using HPLC.

Entities: Chemical Species

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Year: 1989 PMID： 2764707 DOI： 10.1007/BF00316370

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

18 in total

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors: T OMURA; R SATO
Journal: J Biol Chem Date: 1964-07 Impact factor: 5.157

2. 1,2-dihydro-1,2-dihydroxybenzene and several other substances in the metabolism of benzene.

Authors: T SATO; T FUKUYAMA; T SUZUKI; H YOSHIKAWA
Journal: J Biochem Date: 1963-01 Impact factor: 3.387

3. Studies in detoxication. 19. The metabolism of benzene. I. (a) The determination of phenol in urine with 2:6-dichloroquinonechloroimide. (b) The excretion of phenol, glucuronic acid and ethereal sulphate by rabbits receiving benzene and phenol. (c) Observations on the determination of catechol, quinol and muconic acid in urine.

Authors: J W Porteous; R T Williams
Journal: Biochem J Date: 1949 Impact factor: 3.857

4. 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C.

Authors: M V Reddy; K Randerath
Journal: Mutat Res Date: 1987-07 Impact factor: 2.433

5. Metabolism of benzene and phenol in macrophages in vitro and the inhibition of RNA synthesis by benzene metabolites.

Authors: G Post; R Snyder; G F Kalf
Journal: Cell Biol Toxicol Date: 1986-06 Impact factor: 6.691

6. Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

Authors: M V Reddy; K Randerath
Journal: Carcinogenesis Date: 1986-09 Impact factor: 4.944

7. 32P-postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents.

Authors: M V Reddy; R C Gupta; E Randerath; K Randerath
Journal: Carcinogenesis Date: 1984-02 Impact factor: 4.944

8. Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinone.

Authors: G B Post; R Snyder; G F Kalf
Journal: Toxicol Lett Date: 1985-12 Impact factor: 4.372

Review 7. The toxicology of benzene.

Authors: R Snyder; G Witz; B D Goldstein
Journal: Environ Health Perspect Date: 1993-04 Impact factor: 9.031

7 in total

An in vivo study of benzene metabolite DNA adduct formation in liver of male New Zealand rabbits.

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. 1,2-dihydro-1,2-dihydroxybenzene and several other substances in the metabolism of benzene.

4. 32P-analysis of DNA adducts in somatic and reproductive tissues of rats treated with the anticancer antibiotic, mitomycin C.

5. Metabolism of benzene and phenol in macrophages in vitro and the inhibition of RNA synthesis by benzene metabolites.

6. Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

7. 32P-postlabeling test for covalent DNA binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents.

8. Inhibition of RNA synthesis and interleukin-2 production in lymphocytes in vitro by benzene and its metabolites, hydroquinone and p-benzoquinone.

9. Covalent binding of benzene and its metabolites to DNA in rabbit bone marrow mitochondria in vitro.

10. Partial hepatectomy reduces both metabolism and toxicity of benzene.

1. Tissue distribution of DNA adducts and their persistence in blood of mice exposed to benzene.

2. Formation and repair of tobacco carcinogen-derived bulky DNA adducts.

3. Investigation of the DNA adducts formed in B6C3F1 mice treated with benzene: implications for molecular dosimetry.

4. Phenylguanine found in urine after benzene exposure.

5. The contribution of benzene to smoking-induced leukemia.

Review 6. On cancer risk estimation of urban air pollution.

Review 7. The toxicology of benzene.