Literature DB >> 9118887

Phenylguanine found in urine after benzene exposure.

K H Norpoth1, G Müller, C Schell, E Jorg.   

Abstract

Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high performance liquid chromatography, and two immunoassays (enzyme-linked immunosorbent assay and fluoroimmunoassay) with appropriate monoclonal antibodies were used. The results indicate the excretion of several benzene-related guanine adducts slightly different from N7-phenylguanine that may possibly be hydroxylated. These adducts differ also from (O6-, N2- and C8-phenylguanine, respectively.

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Year:  1996        PMID： 9118887      PMCID： PMC1469737          DOI： 10.1289/ehp.961041159

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  16 in total

1.  Metabolism of polycyclic compounds. 21. The metabolism of phenanthrene in rabbits and rats: dihydrodihydroxy compounds and related glucosiduronic acids.

Authors:  E BOYLAND; P SIMS
Journal:  Biochem J       Date:  1962-09       Impact factor: 3.857

2.  Detection of (3'-hydroxy)-3,N4-benzetheno-2'-deoxycytidine-3'-phosphate by 32P-postlabeling of DNA reacted with p-benzoquinone.

Authors:  K Pongracz; S Kaur; A L Burlingame; W J Bodell
Journal:  Carcinogenesis       Date:  1990-09       Impact factor: 4.944

3.  Metabolism of polycyclic compounds. 25. The metabolism of anthracene and some related compounds in rats.

Authors:  P Sims
Journal:  Biochem J       Date:  1964-09       Impact factor: 3.857

4.  Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.

Authors:  N Kinoshita; H V Gelboin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

5.  Synthesis and characterization of deoxyguanosine-benzoquinone adducts.

Authors:  L Jowa; G Witz; R Snyder; S Winkle; G F Kalf
Journal:  J Appl Toxicol       Date:  1990-02       Impact factor: 3.446

6.  Studies on guanine adducts excreted in rat urine after benzene exposure.

Authors:  E Krewet; C Verkoyen; G Müller; C Schell; W Popp; K Norpoth
Journal:  Carcinogenesis       Date:  1993-02       Impact factor: 4.944

7.  Production and characterization of monoclonal antibodies to N7-phenylguanine.

Authors:  C Schell; C Verkoyen; E Krewet; G Müller; K Norpoth
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553

8.  Covalent binding of benzene and its metabolites to DNA in rabbit bone marrow mitochondria in vitro.

Authors:  T Rushmore; R Snyder; G Kalf
Journal:  Chem Biol Interact       Date:  1984-04       Impact factor: 5.192

9.  A method for in vitro culture of rat Zymbal gland: use in mechanistic studies of benzene carcinogenesis in combination with 32P-postlabeling.

Authors:  M V Reddy; G R Blackburn; S E Irwin; C Kommineni; C R Mackerer; M A Mehlman
Journal:  Environ Health Perspect       Date:  1989-07       Impact factor: 9.031

10.  Chromatographic and spectrophotometric characterization of adducts formed during the reaction of trans,trans-muconaldehyde with 14C-deoxyguanosine 5'-phosphate.

Authors:  L Latriano; G Witz; B D Goldstein; A M Jeffrey
Journal:  Environ Health Perspect       Date:  1989-07       Impact factor: 9.031
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  1 in total

Review 1.  The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Authors:  Scott M Arnold; Juergen Angerer; Peter J Boogaard; Michael F Hughes; Raegan B O'Lone; Steven H Robison; A Robert Schnatter
Journal:  Crit Rev Toxicol       Date:  2013-02       Impact factor: 5.635
  1 in total

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