Literature DB >> 27626199

Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense.

Harding H Luan1, Ruslan Medzhitov2.   

Abstract

Itaconate is a newly discovered mammalian metabolite bearing significant implications for our understanding of cellular immunometabolism and antimicrobial defense. Here, we explore recent findings regarding the role of itaconate in the innate immune response and highlight the emerging principle that metabolites can have distinct immunological functions independent of bioenergetics.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27626199      PMCID： PMC5024735          DOI： 10.1016/j.cmet.2016.08.013

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  55 in total

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