Literature DB >> 30791134

Regulation of leukocyte function by citric acid cycle intermediates.

Naeem K Patil1, Julia K Bohannon1,2, Antonio Hernandez1, Tazeen K Patil3, Edward R Sherwood1,2.   

Abstract

Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions. ©2019 Society for Leukocyte Biology.

Entities:  

Keywords:  citrate; fumarate; itaconate; metabolic reprogramming; succinate

Mesh：

Substances：

Year:  2019        PMID： 30791134      PMCID： PMC6597293          DOI： 10.1002/JLB.3MIR1118-415R

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  69 in total

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