Literature DB >> 27620478

mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil.

Caio Augusto Martins Aires1, Polyana Silva Pereira1, Marise Dutra Asensi2, Ana Paula D'Alincourt Carvalho-Assef2.   

Abstract

We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126 Klebsiella pneumoniae isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of mgrB gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored blaKPC-2 (n = 8) and belonged to clonal complex 258 (CC258) (n = 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27620478      PMCID： PMC5075120          DOI： 10.1128/AAC.01456-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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2.  Emergence of Infections due to a Polymyxin B-Resistant KPC-2-Producing Klebsiella pneumoniae in Critically Ill Patients: What Is the Role of a Previous Colonization?

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3.  Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study.

Authors:  D R Giacobbe; V Del Bono; E M Trecarichi; F G De Rosa; M Giannella; M Bassetti; A Bartoloni; A R Losito; S Corcione; M Bartoletti; E Mantengoli; C Saffioti; N Pagani; S Tedeschi; T Spanu; G M Rossolini; A Marchese; S Ambretti; R Cauda; P Viale; C Viscoli; M Tumbarello
Journal:  Clin Microbiol Infect       Date:  2015-08-14       Impact factor: 8.067

4.  Update of the molecular epidemiology of KPC-2-producing Klebsiella pneumoniae in Brazil: spread of clonal complex 11 (ST11, ST437 and ST340).

Authors:  Polyana Silva Pereira; Carlos Felipe Machado de Araujo; Liliane Miyuki Seki; Viviane Zahner; Ana Paula D'Alincourt Carvalho-Assef; Marise Dutra Asensi
Journal:  J Antimicrob Chemother       Date:  2012-10-15       Impact factor: 5.790

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5.  Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort Study.

Authors:  Nenad Macesic; Brian Nelson; Thomas H Mcconville; Marla J Giddins; Daniel A Green; Stephania Stump; Angela Gomez-Simmonds; Medini K Annavajhala; Anne-Catrin Uhlemann
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Review 7.  Causes of polymyxin treatment failure and new derivatives to fill the gap.

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8.  Risk factors for acquisition of colistin-resistant Klebsiella pneumoniae and expansion of a colistin-resistant ST307 epidemic clone in hospitals in Marseille, France, 2014 to 2017.

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9.  An Outbreak of Carbapenem-Resistant Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Chongqing, China.

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