Gilberto Gambero Gaspar1, Fernando Bellissimo-Rodrigues2, Leonardo Neves de Andrade3, Ana Lúcia Darini3, Roberto Martinez4. 1. Serviço de Controle de Infecção Hospitalar, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, BR. 2. Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, BR. 3. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, BR. 4. Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, São Paulo, BR.
Abstract
INTRODUCTION: Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection. METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae. CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.
INTRODUCTION: Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection. METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae. CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.
Authors: Miranda E Pitt; Alysha G Elliott; Minh Duc Cao; Devika Ganesamoorthy; Ilias Karaiskos; Helen Giamarellou; Cely S Abboud; Mark A T Blaskovich; Matthew A Cooper; Lachlan J M Coin Journal: Microb Genom Date: 2018-02-12
Authors: Gilberto G Gaspar; Gustavo Tamasco; Nathália Abichabki; Ana Flavia T Scaranello; Maria Auxiliadora-Martins; Renata Pocente; Leonardo N Andrade; María-Eugenia Guazzaroni; Rafael Silva-Rocha; Valdes R Bollela Journal: Antibiotics (Basel) Date: 2022-06-17