Mehmet Giray Ersoz1, Duygu Kunak Mart2, Emre Ayintap2, Leyla Hazar3, Irfan Botan Gunes4, Seda Karaca Adiyeke2, Beysim Dogan5. 1. Department of Ophthalmology, Kızıltepe Government Hospital, 47400, Kiziltepe, Mardin, Turkey. m.girayersoz@gmail.com. 2. Department of Ophthalmology, Tepecik Education and Research Hospital, 35260, Izmir, Turkey. 3. Department of Ophthalmology, Kızıltepe Government Hospital, 47400, Kiziltepe, Mardin, Turkey. 4. Department of Ophthalmology, Borçka Government Hospital, 08400, Artvin, Turkey. 5. Department of Ophthalmology, Odemis Government Hospital, 35750, Izmir, Turkey.
Abstract
PURPOSE: To investigate whether there is a difference between primary open-angle glaucoma (POAG) patients and control group with regard to choroidal thickness (CT) and the factors influencing CT. METHODS: Ninety eyes of 90 patients who were being followed up with POAG and 72 eyes of 72 healthy subjects matched for age and gender were included. Peripapillary retinal nerve fiber layer thickness (RNFLT), peripapillary CT, lamina cribrosa thickness (LCT), and prelaminar tissue thickness (PTT) were measured with spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI) in all patients. RESULTS: According to multi-variable linear regression analysis results, the factors influencing CT were found as axial length (AL) (B = -22.78, p = 0.002), intraocular pressure (IOP) (B = -7.95, p = 0.001), age (B = -1.77, p = 0.009), and radial pulse rate (B = 1.42, p = 0.015). A statistically significant relationship was not detected between CT and central corneal thickness, mean deviation value of visual field, cup/disk ratio, RNFLT, LCT, PTT. CT was found significantly thinner in glaucoma group (147.5 ± 61.2 μm) compared to control group (167.1 ± 37.3 μm). However, IOP was found significantly higher (p < 0.001) and pulse rate was found significantly lower (p = 0.021) in POAG group. IOP and pulse rate were considered to have affected CT difference between the groups. In advanced and worser stage patients, there were significant positive correlations between CT and RNFLT in inferior and superior quadrants. CONCLUSIONS: In addition to previous studies, IOP and pulse rate were detected to be effective on CT. Further studies are required for determining the whole factors effective on CT and better understanding CT and glaucoma relationship.
PURPOSE: To investigate whether there is a difference between primary open-angle glaucoma (POAG) patients and control group with regard to choroidal thickness (CT) and the factors influencing CT. METHODS: Ninety eyes of 90 patients who were being followed up with POAG and 72 eyes of 72 healthy subjects matched for age and gender were included. Peripapillary retinal nerve fiber layer thickness (RNFLT), peripapillary CT, lamina cribrosa thickness (LCT), and prelaminar tissue thickness (PTT) were measured with spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI) in all patients. RESULTS: According to multi-variable linear regression analysis results, the factors influencing CT were found as axial length (AL) (B = -22.78, p = 0.002), intraocular pressure (IOP) (B = -7.95, p = 0.001), age (B = -1.77, p = 0.009), and radial pulse rate (B = 1.42, p = 0.015). A statistically significant relationship was not detected between CT and central corneal thickness, mean deviation value of visual field, cup/disk ratio, RNFLT, LCT, PTT. CT was found significantly thinner in glaucoma group (147.5 ± 61.2 μm) compared to control group (167.1 ± 37.3 μm). However, IOP was found significantly higher (p < 0.001) and pulse rate was found significantly lower (p = 0.021) in POAG group. IOP and pulse rate were considered to have affected CT difference between the groups. In advanced and worser stage patients, there were significant positive correlations between CT and RNFLT in inferior and superior quadrants. CONCLUSIONS: In addition to previous studies, IOP and pulse rate were detected to be effective on CT. Further studies are required for determining the whole factors effective on CT and better understanding CT and glaucoma relationship.
Authors: Mehmet Ozgur Zengin; Esat Cinar; Eyyup Karahan; Ibrahim Tuncer; Sami Yilmaz; Tolga Kocaturk; Cem Kucukerdonmez Journal: Int Ophthalmol Date: 2014-07-25 Impact factor: 2.031
Authors: Hongli Yang; Haomin Luo; Stuart K Gardiner; Christy Hardin; Glen P Sharpe; Joseph Caprioli; Shaban Demirel; Christopher A Girkin; Jeffrey M Liebmann; Christian Y Mardin; Harry A Quigley; Alexander F Scheuerle; Brad Fortune; Balwantray C Chauhan; Claude F Burgoyne Journal: Invest Ophthalmol Vis Sci Date: 2019-02-01 Impact factor: 4.799