Hae-Young Lopilly Park1, Na-Young Lee, Hae-Young Shin, Chan Kee Park. 1. *Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital †Department of Ophthalmology and Visual Science, Incheon St Mary's Hospital ‡Department of Ophthalmology and Visual Science, Uijeongbu St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
BACKGROUND: To compare the macular and peripapillary choroidal thickness between normal and glaucoma eyes and find out factors related to choroidal thickness using enhanced depth imaging (EDI) of Heidelberg Spectralis SD-OCT. STUDY DESIGN: Cross-sectional transverse study. METHODS: A total of 108 glaucoma patients and 48 healthy controls were included in the analysis. Choroidal thickness was measured from 6 mm length radial B-scans at the macular and the optic nerve head by EDI OCT. Choroidal thickness was compared between normal controls, normal tension glaucoma (NTG) patients, and primary open-angle glaucoma (POAG) patients. Factors related to choroidal thickness were analyzed by regression analysis. RESULTS: There were no differences in average, temporal, nasal, superior, and inferior macular choroidal thickness between normal, NTG, and POAG eyes. The peripapillary thickness did not differ between normal and POAG eyes; however, average, temporal, nasal, superior, and inferior peripapillary choroidal thickness were significantly thinner in NTG eyes. Axial length (β=-11.36, P<0.001) was the most significant factor associated with peripapillary choroidal thickness, followed by age (β=-5.10, P<0.001). Glaucoma type (β=-11.28, P<0.001) were also significantly associated with peripapillary choroidal thickness. CONCLUSIONS: Peripapillary choroidal thickness was significantly reduced in NTG eyes based on EDI OCT measurements in vivo.
BACKGROUND: To compare the macular and peripapillary choroidal thickness between normal and glaucoma eyes and find out factors related to choroidal thickness using enhanced depth imaging (EDI) of Heidelberg Spectralis SD-OCT. STUDY DESIGN: Cross-sectional transverse study. METHODS: A total of 108 glaucomapatients and 48 healthy controls were included in the analysis. Choroidal thickness was measured from 6 mm length radial B-scans at the macular and the optic nerve head by EDI OCT. Choroidal thickness was compared between normal controls, normal tension glaucoma (NTG) patients, and primary open-angle glaucoma (POAG) patients. Factors related to choroidal thickness were analyzed by regression analysis. RESULTS: There were no differences in average, temporal, nasal, superior, and inferior macular choroidal thickness between normal, NTG, and POAG eyes. The peripapillary thickness did not differ between normal and POAG eyes; however, average, temporal, nasal, superior, and inferior peripapillary choroidal thickness were significantly thinner in NTG eyes. Axial length (β=-11.36, P<0.001) was the most significant factor associated with peripapillary choroidal thickness, followed by age (β=-5.10, P<0.001). Glaucoma type (β=-11.28, P<0.001) were also significantly associated with peripapillary choroidal thickness. CONCLUSIONS:Peripapillary choroidal thickness was significantly reduced in NTG eyes based on EDI OCT measurements in vivo.
Authors: Lindsay A Rhodes; Carrie Huisingh; John Johnstone; Massimo A Fazio; Brandon Smith; Lan Wang; Mark Clark; J Crawford Downs; Cynthia Owsley; Michael J A Girard; Jean Martial Mari; Christopher A Girkin Journal: Invest Ophthalmol Vis Sci Date: 2015-02-24 Impact factor: 4.799
Authors: Rusdeep S Mundae; Linda M Zangwill; Sami W Kabbara; Naama Hammel; Christopher Bowd; Felipe A Medeiros; Christopher A Girkin; Jeffrey M Liebmann; Robert N Weinreb; Akram Belghith Journal: Am J Ophthalmol Date: 2017-12-19 Impact factor: 5.258