BACKGROUND: Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma. OBJECTIVE: We prospectively assessed the relation between physical and sexual abuse during childhood and adolescence and the incidence of adult-onset asthma in the Black Women's Health Study. METHODS: We followed 28,456 women from 1995 through 2011 with biennial mailed questionnaires. Experiences of physical and sexual abuse that occurred during childhood and adolescence were obtained in 2005. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% CIs. RESULTS: During 417,931 person-years of follow-up, 1,160 participants reported physician-diagnosed asthma and concurrent use of asthma medication. Compared with women who experienced no abuse during childhood or adolescence, the multivariable IRR for any childhood abuse was 1.24 (95% CI, 1.06-1.45), and for any adolescent abuse, it was 1.10 (95% CI, 0.88-1.36). The IRR was higher for childhood physical abuse (IRR, 1.29; 95% CI, 1.07-1.49) than for childhood sexual abuse (IRR, 1.15; 95% CI, 0.88-1.49). IRRs for physical and sexual abuse during adolescence were compatible with 1.0. The association between childhood abuse and asthma incidence was stronger in older compared with younger women. CONCLUSION: In this large cohort of African American women, there was a positive association between adult-onset asthma and childhood physical abuse and weaker associations for childhood sexual abuse and any abuse during adolescence. Given the high prevalence of asthma and childhood abuse, this association is of public health importance.
BACKGROUND: Experiences of violence contribute to the occurrence of childhood asthma, but there is little information on the effect of early-life abuse on adult-onset asthma. OBJECTIVE: We prospectively assessed the relation between physical and sexual abuse during childhood and adolescence and the incidence of adult-onset asthma in the Black Women's Health Study. METHODS: We followed 28,456 women from 1995 through 2011 with biennial mailed questionnaires. Experiences of physical and sexual abuse that occurred during childhood and adolescence were obtained in 2005. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% CIs. RESULTS: During 417,931 person-years of follow-up, 1,160 participants reported physician-diagnosed asthma and concurrent use of asthma medication. Compared with women who experienced no abuse during childhood or adolescence, the multivariable IRR for any childhood abuse was 1.24 (95% CI, 1.06-1.45), and for any adolescent abuse, it was 1.10 (95% CI, 0.88-1.36). The IRR was higher for childhood physical abuse (IRR, 1.29; 95% CI, 1.07-1.49) than for childhood sexual abuse (IRR, 1.15; 95% CI, 0.88-1.49). IRRs for physical and sexual abuse during adolescence were compatible with 1.0. The association between childhood abuse and asthma incidence was stronger in older compared with younger women. CONCLUSION: In this large cohort of African American women, there was a positive association between adult-onset asthma and childhood physical abuse and weaker associations for childhood sexual abuse and any abuse during adolescence. Given the high prevalence of asthma and childhood abuse, this association is of public health importance.
Authors: Lin Ying Liu; Christopher L Coe; Cheri A Swenson; Elizabeth A Kelly; Hirohito Kita; William W Busse Journal: Am J Respir Crit Care Med Date: 2002-04-15 Impact factor: 21.405
Authors: Hans Degens; Thomas Mark Maden-Wilkinson; Alex Ireland; Marko T Korhonen; Harri Suominen; Ari Heinonen; Zsolt Radak; Jamie S McPhee; Jörn Rittweger Journal: Age (Dordr) Date: 2012-04-28
Authors: Kate M Scott; Michael Von Korff; Jordi Alonso; Matthias C Angermeyer; Corina Benjet; Ronny Bruffaerts; Giovanni de Girolamo; Josep Maria Haro; Ronald C Kessler; Viviane Kovess; Yutaka Ono; Johan Ormel; José Posada-Villa Journal: Psychosom Med Date: 2008-10-21 Impact factor: 4.312
Authors: Christian Rosas-Salazar; Yueh-Ying Han; John M Brehm; Erick Forno; Edna Acosta-Pérez; Michelle M Cloutier; María Alvarez; Angel Colón-Semidey; Glorisa Canino; Juan C Celedón Journal: Chest Date: 2016-02-18 Impact factor: 9.410
Authors: Bizu Gelaye; Ngan Do; Samantha Avila; Juan Carlos Velez; Qiu-Yue Zhong; Sixto E Sanchez; B Lee Peterlin; Michelle A Williams Journal: Headache Date: 2016-05-31 Impact factor: 5.887
Authors: Patricia F Coogan; Jeffrey Yu; George T O'Connor; Timothy A Brown; Julie R Palmer; Lynn Rosenberg Journal: Ann Allergy Asthma Immunol Date: 2014-01-17 Impact factor: 6.347
Authors: Patricia F Coogan; Jeffrey Yu; George T O'Connor; Timothy A Brown; Yvette C Cozier; Julie R Palmer; Lynn Rosenberg Journal: Chest Date: 2014-03-01 Impact factor: 9.410
Authors: Alexandra E Shields; Lauren A Wise; Edward A Ruiz-Narvaez; Bobak Seddighzadeh; Hyang-Min Byun; Yvette C Cozier; Lynn Rosenberg; Julie R Palmer; Andrea A Baccarelli Journal: Epigenomics Date: 2016-09-13 Impact factor: 4.778