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Literature DB >> 24675284

Epigenetics: a new way to look at kidney diseases.

Pazit Beckerman¹, Yi-An Ko¹, Katalin Susztak¹.

Abstract

Only a few percent of the 3 billion pairs of chemical letters in the human genome is responsible for protein-coding sequences. Recent advances in the field of epigenomics have helped us to understand how most of the remaining sequences are responsible for gene regulation at baseline and in disease conditions. Here we discuss recent advances in the area of epigenetics--specifically in cytosine modifications--and its application in the field of nephrology.

Entities: Chemical Disease Species

Keywords: chronic kidney disease; cytosine methylation; enhancers; epigenetics

Mesh：

Year: 2014 PMID： 24675284 PMCID： PMC4173816 DOI： 10.1093/ndt/gfu026

Source DB: PubMed Journal: Nephrol Dial Transplant ISSN： 0931-0509 Impact factor: 5.992

45 in total

1. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.

Authors: Kristine Williams; Jesper Christensen; Marianne Terndrup Pedersen; Jens V Johansen; Paul A C Cloos; Juri Rappsilber; Kristian Helin
Journal: Nature Date: 2011-04-13 Impact factor: 49.962

Review 2. Fine tuning gene expression: the epigenome.

Authors: Davoud Mohtat; Katalin Susztak
Journal: Semin Nephrol Date: 2010-09 Impact factor: 5.299

3. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.

Authors: Ken Inoki; Hiroyuki Mori; Junying Wang; Tsukasa Suzuki; SungKi Hong; Sei Yoshida; Simone M Blattner; Tsuneo Ikenoue; Markus A Rüegg; Michael N Hall; David J Kwiatkowski; Maria P Rastaldi; Tobias B Huber; Matthias Kretzler; Lawrence B Holzman; Roger C Wiggins; Kun-Liang Guan
Journal: J Clin Invest Date: 2011-05-23 Impact factor: 14.808

4. DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy.

Authors: Carmen Sapienza; Jean Lee; Jasmine Powell; Oluwatoyin Erinle; Faahud Yafai; James Reichert; Elias S Siraj; Michael Madaio
Journal: Epigenetics Date: 2011-01-01 Impact factor: 4.528

5. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort.

Authors: Ian H de Boer; Tessa C Rue; Patricia A Cleary; John M Lachin; Mark E Molitch; Michael W Steffes; Wanjie Sun; Bernard Zinman; John D Brunzell; Neil H White; Ronald P Danis; Matthew D Davis; Dean Hainsworth; Larry D Hubbard; David M Nathan
Journal: Arch Intern Med Date: 2011-03-14

6. Methylation determines fibroblast activation and fibrogenesis in the kidney.

Authors: Wibke Bechtel; Scott McGoohan; Elisabeth M Zeisberg; Gerhard A Müller; Hubert Kalbacher; David J Salant; Claudia A Müller; Raghu Kalluri; Michael Zeisberg
Journal: Nat Med Date: 2010-04-25 Impact factor: 53.440

7. ChIP-seq accurately predicts tissue-specific activity of enhancers.

Authors: Axel Visel; Matthew J Blow; Zirong Li; Tao Zhang; Jennifer A Akiyama; Amy Holt; Ingrid Plajzer-Frick; Malak Shoukry; Crystal Wright; Feng Chen; Veena Afzal; Bing Ren; Edward M Rubin; Len A Pennacchio
Journal: Nature Date: 2009-02-12 Impact factor: 49.962

8. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain.

Authors: Jessica M Davison; Tiffany J Mellott; Vesela P Kovacheva; Jan Krzysztof Blusztajn
Journal: J Biol Chem Date: 2008-11-10 Impact factor: 5.157

9. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Authors: Myunggon Ko; Yun Huang; Anna M Jankowska; Utz J Pape; Mamta Tahiliani; Hozefa S Bandukwala; Jungeun An; Edward D Lamperti; Kian Peng Koh; Rebecca Ganetzky; X Shirley Liu; L Aravind; Suneet Agarwal; Jaroslaw P Maciejewski; Anjana Rao
Journal: Nature Date: 2010-12-09 Impact factor: 49.962

10. Mapping and analysis of chromatin state dynamics in nine human cell types.

Authors: Jason Ernst; Pouya Kheradpour; Tarjei S Mikkelsen; Noam Shoresh; Lucas D Ward; Charles B Epstein; Xiaolan Zhang; Li Wang; Robbyn Issner; Michael Coyne; Manching Ku; Timothy Durham; Manolis Kellis; Bradley E Bernstein
Journal: Nature Date: 2011-03-23 Impact factor: 49.962

28 in total

1. Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Authors: Evan D Rosen; Klaus H Kaestner; Rama Natarajan; Mary-Elizabeth Patti; Richard Sallari; Maike Sander; Katalin Susztak
Journal: Diabetes Date: 2018-10 Impact factor: 9.461

Review 2. The nephrologist of tomorrow: towards a kidney-omic future.

Authors: Mina H Hanna; Alessandra Dalla Gassa; Gert Mayer; Gianluigi Zaza; Patrick D Brophy; Loreto Gesualdo; Francesco Pesce
Journal: Pediatr Nephrol Date: 2016-03-09 Impact factor: 3.714

3. Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism.

Authors: Gregory J Weber; Sathnur B Pushpakumar; Utpal Sen
Journal: Am J Physiol Heart Circ Physiol Date: 2017-02-17 Impact factor: 4.733

4. Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.

Authors: Xin Sheng; Chengxiang Qiu; Hongbo Liu; Caroline Gluck; Jesse Y Hsu; Jiang He; Chi-Yuan Hsu; Daohang Sha; Matthew R Weir; Tamara Isakova; Dominic Raj; Hernan Rincon-Choles; Harold I Feldman; Raymond Townsend; Hongzhe Li; Katalin Susztak
Journal: Proc Natl Acad Sci U S A Date: 2020-11-03 Impact factor: 11.205