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Literature DB >> 27610753

Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.

Andrew V Mossine¹, Stephen Thompson¹, Allen F Brooks¹, Alexandra R Sowa², Jason M Miller², Peter Jh Scott^1,2.

Abstract

Fluorine-18 ((18)F) is one of the most common positron-emitting radionuclides used in the synthesis of positron emission tomography radiotracers due to its ready availability, convenient half-life and outstanding imaging properties. In Part 1 of this review, we presented the first analysis of patents issued for novel radiotracers labeled with fluorine-18. In Part 2, we follow-up with a focus on patents issued for new radiochemistry methodology using fluorine-18 issued between January 2009 and December 2015.

Entities: Chemical

Keywords: 18F; PET radiotracers; fluorine-18; positron emission tomography; radiochemistry

Mesh：

Substances：
Fluorine Radioisotopes

Year: 2016 PMID： 27610753 PMCID： PMC5138992 DOI： 10.4155/ppa-2016-0028

Source DB: PubMed Journal: Pharm Pat Anal ISSN： 2046-8954

51 in total

1. The traceless Staudinger ligation for indirect 18F-radiolabelling.

Authors: Laurence Carroll; Sophie Boldon; Romain Bejot; Jane E Moore; Jérôme Declerck; Véronique Gouverneur
Journal: Org Biomol Chem Date: 2010-11-22 Impact factor: 3.876

2. Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.

Authors: Megan N Stewart; Brian G Hockley; Peter J H Scott
Journal: Chem Commun (Camb) Date: 2015-08-24 Impact factor: 6.222

3. Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.

Authors: T Rühl; W Rafique; V T Lien; P J Riss
Journal: Chem Commun (Camb) Date: 2014-04-28 Impact factor: 6.222

4. Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye.

Authors: Shuanglong Liu; Dan Li; Zhe Zhang; G K Surya Prakash; Peter S Conti; Zibo Li
Journal: Chem Commun (Camb) Date: 2014-07-14 Impact factor: 6.222

5. Fluorous synthesis of 18F radiotracers with the [18F]fluoride ion: nucleophilic fluorination as the detagging process.

Authors: Romain Bejot; Thomas Fowler; Laurence Carroll; Sophie Boldon; Jane E Moore; Jérôme Declerck; Véronique Gouverneur
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

Review 6. Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

Authors: Jiang Wang; María Sánchez-Roselló; José Luis Aceña; Carlos del Pozo; Alexander E Sorochinsky; Santos Fustero; Vadim A Soloshonok; Hong Liu
Journal: Chem Rev Date: 2013-12-03 Impact factor: 60.622

7. A general copper-mediated nucleophilic 18F fluorination of arenes.

Authors: Matthew Tredwell; Sean M Preshlock; Nicholas J Taylor; Stefan Gruber; Mickael Huiban; Jan Passchier; Joël Mercier; Christophe Génicot; Véronique Gouverneur
Journal: Angew Chem Int Ed Engl Date: 2014-06-10 Impact factor: 15.336

Review 8. From Unorthodox to Established: The Current Status of (18)F-Trifluoroborate- and (18)F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging.

Authors: Vadim Bernard-Gauthier; Justin J Bailey; Zhibo Liu; Björn Wängler; Carmen Wängler; Klaus Jurkschat; David M Perrin; Ralf Schirrmacher
Journal: Bioconjug Chem Date: 2015-11-25 Impact factor: 4.774

Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.

1. The traceless Staudinger ligation for indirect 18F-radiolabelling.

2. Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.

3. Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.

4. Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye.

5. Fluorous synthesis of 18F radiotracers with the [18F]fluoride ion: nucleophilic fluorination as the detagging process.

Review 6. Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

7. A general copper-mediated nucleophilic 18F fluorination of arenes.

Review 8. From Unorthodox to Established: The Current Status of (18)F-Trifluoroborate- and (18)F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging.

9. Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18.

10. Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids.

1. Copper-Mediated Late-stage Radiofluorination: Five Years of Impact on Pre-clinical and Clinical PET Imaging.

2. Optimization of Precursor Synthesis Conditions of (2S,4S)4-[¹⁸F]FPArg and Its Application in Glioma Imaging.

Review 3. Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors.