Literature DB >> 26300287

Green approaches to late-stage fluorination: radiosyntheses of (18)F-labelled radiopharmaceuticals in ethanol and water.

Megan N Stewart1, Brian G Hockley, Peter J H Scott.   

Abstract

Green strategies for late-stage fluorination with (18)F, in which ethanol and water are the only solvents used throughout the entire radiolabeling process (azeotropic drying, nucleophilic fluorination, purification and formulation), have been developed and applied to the radiosyntheses of a range of radiopharmaceuticals commonly employed in clinical PET imaging.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26300287     DOI： 10.1039/c5cc05919d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.

Authors:  Andrew V Mossine; Stephen Thompson; Allen F Brooks; Alexandra R Sowa; Jason M Miller; Peter Jh Scott
Journal:  Pharm Pat Anal       Date:  2016-09

2.  Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18.

Authors:  Falguni Basuli; Xiang Zhang; Elaine M Jagoda; Peter L Choyke; Rolf E Swenson
Journal:  Nucl Med Biol       Date:  2016-08-30       Impact factor: 2.408

3.  Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination.

Authors:  Andrew V Mossine; Allen F Brooks; Naoko Ichiishi; Katarina J Makaravage; Melanie S Sanford; Peter J H Scott
Journal:  Sci Rep       Date:  2017-03-22       Impact factor: 4.379

4.  An updated radiosynthesis of [18F]AV1451 for tau PET imaging.

Authors:  Andrew V Mossine; Allen F Brooks; Bradford D Henderson; Brian G Hockley; Kirk A Frey; Peter J H Scott
Journal:  EJNMMI Radiopharm Chem       Date:  2017-06-06

5.  Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[18F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson's Disease.

Authors:  Tanpreet Kaur; Allen F Brooks; Katherine M Liddell; Bradford D Henderson; Brian G Hockley; Nicolaas I Bohnen; Roger L Albin; Peter J H Scott
Journal:  Front Chem       Date:  2022-03-30       Impact factor: 5.221
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.