Literature DB >> 27599271

A Mutasynthetic Library of Platensimycin and Platencin Analogues.

Liao-Bin Dong1, Jeffrey D Rudolf1, Ben Shen1.   

Abstract

Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.

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Year:  2016        PMID： 27599271      PMCID： PMC5048679          DOI： 10.1021/acs.orglett.6b02248

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  18 in total

1.  Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.

Authors:  Michael J Smanski; Zhiguo Yu; Jeffrey Casper; Shuangjun Lin; Ryan M Peterson; Yihua Chen; Evelyn Wendt-Pienkowski; Scott R Rajski; Ben Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-08       Impact factor: 11.205

2.  A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

Authors:  Jeffrey D Rudolf; Liao-Bin Dong; Tingting Huang; Ben Shen
Journal:  Mol Biosyst       Date:  2015-10

3.  Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

Authors:  Sheo B Singh; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri B Herath; Chaowei Zhang; Deborah L Zink; Nancy N Tsou; Richard G Ball; Angela Basilio; Olga Genilloud; Maria Teresa Diez; Francisca Vicente; Fernando Pelaez; Katherine Young; Jun Wang
Journal:  J Am Chem Soc       Date:  2006-09-13       Impact factor: 15.419

4.  Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.

Authors:  Margaret Wu; Sheo B Singh; Jun Wang; Christine C Chung; Gino Salituro; Bindhu V Karanam; Sang Ho Lee; Maryann Powles; Kenneth P Ellsworth; Michael E Lassman; Corey Miller; Robert W Myers; Michael R Tota; Bei B Zhang; Cai Li
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-09       Impact factor: 11.205

5.  Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Authors:  Jun Wang; Stephen M Soisson; Katherine Young; Wesley Shoop; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Gopalakrishnan Parthasarathy; Yui S Tang; Richard Cummings; Sookhee Ha; Karen Dorso; Mary Motyl; Hiranthi Jayasuriya; John Ondeyka; Kithsiri Herath; Chaowei Zhang; Lorraine Hernandez; John Allocco; Angela Basilio; José R Tormo; Olga Genilloud; Francisca Vicente; Fernando Pelaez; Lawrence Colwell; Sang Ho Lee; Bruce Michael; Thomas Felcetto; Charles Gill; Lynn L Silver; Jeffery D Hermes; Ken Bartizal; John Barrett; Dennis Schmatz; Joseph W Becker; Doris Cully; Sheo B Singh
Journal:  Nature       Date:  2006-05-18       Impact factor: 49.962

6.  Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Authors:  Jun Wang; Srinivas Kodali; Sang Ho Lee; Andrew Galgoci; Ronald Painter; Karen Dorso; Fred Racine; Mary Motyl; Lorraine Hernandez; Elizabeth Tinney; Steven L Colletti; Kithsiri Herath; Richard Cummings; Oscar Salazar; Ignacio González; Angela Basilio; Francisca Vicente; Olga Genilloud; Fernando Pelaez; Hiranthi Jayasuriya; Katherine Young; Doris F Cully; Sheo B Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-24       Impact factor: 11.205

7.  Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.

Authors:  K C Nicolaou; Antonia F Stepan; Troy Lister; Ang Li; Ana Montero; G Scott Tria; Craig I Turner; Yefeng Tang; Jianhua Wang; Ross M Denton; David J Edmonds
Journal:  J Am Chem Soc       Date:  2008-09-05       Impact factor: 15.419

8.  Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

Authors:  Tingting Huang; Dong Yang; Jeffrey D Rudolf; Pengfei Xie; Guangbo Xie; Qihui Teng; Jeremy R Lohman; Xiangcheng Zhu; Yong Huang; Li-Xing Zhao; Yi Jiang; Yanwen Duan; Ben Shen
Journal:  J Nat Prod       Date:  2014-09-19       Impact factor: 4.050

Review 9.  Arylamine N-acetyltransferases in mycobacteria.

Authors:  Edith Sim; James Sandy; Dimitrios Evangelopoulos; Elizabeth Fullam; Sanjib Bhakta; Isaac Westwood; Anna Krylova; Nathan Lack; Martin Noble
Journal:  Curr Drug Metab       Date:  2008-07       Impact factor: 3.731

10.  Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.

Authors:  Alistair K Brown; Rebecca C Taylor; Apoorva Bhatt; Klaus Fütterer; Gurdyal S Besra
Journal:  PLoS One       Date:  2009-07-17       Impact factor: 3.240
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  10 in total

1.  A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin.

Authors:  Lin Qiu; Kai Tian; Jian Pan; Lin Jiang; Hu Yang; Xiangcheng Zhu; Ben Shen; Yanwen Duan; Yong Huang
Journal:  Tetrahedron       Date:  2016-12-28       Impact factor: 2.457

Review 2.  Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.

Authors:  Christiana N Teijaro; Ajeeth Adhikari; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-13       Impact factor: 3.346

3.  Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions.

Authors:  Youchao Deng; Meng Su; Dingding Kang; Xingyun Liu; Zhongqing Wen; Yuling Li; Lin Qiu; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Med Chem       Date:  2018-12-05       Impact factor: 7.446

Review 4.  Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.

Authors:  Jeffrey D Rudolf; Liao-Bin Dong; Ben Shen
Journal:  Biochem Pharmacol       Date:  2016-11-16       Impact factor: 5.858

5.  In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin.

Authors:  Liao-Bin Dong; Jeffrey D Rudolf; Li Lin; Claudia Ruiz; Michael D Cameron; Ben Shen
Journal:  Bioorg Med Chem       Date:  2017-02-16       Impact factor: 3.641

6.  Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.

Authors:  Meng Su; Lin Qiu; Youchao Deng; Claudia H Ruiz; Jeffrey D Rudolf; Liao-Bin Dong; Xueqiong Feng; Michael D Cameron; Ben Shen; Yanwen Duan; Yong Huang
Journal:  Mol Pharm       Date:  2019-06-19       Impact factor: 4.939

7.  Biosynthetic Origin of the Ether Ring in Platensimycin.

Authors:  Jeffrey D Rudolf; Liao-Bin Dong; Karina Manoogian; Ben Shen
Journal:  J Am Chem Soc       Date:  2016-12-14       Impact factor: 15.419

8.  Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA.

Authors:  Yuling Li; Xiang Weng; Youchao Deng; Jian Pan; Saibin Zhu; Zhongqing Wen; Yanqiu Yuan; Shaowen Li; Ben Shen; Yanwen Duan; Yong Huang
Journal:  ACS Med Chem Lett       Date:  2021-02-15       Impact factor: 4.345

9.  PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases.

Authors:  Cheng-Jian Zheng; Edward Kalkreuter; Bo-Yi Fan; Yu-Chen Liu; Liao-Bin Dong; Ben Shen
Journal:  ACS Chem Biol       Date:  2020-12-14       Impact factor: 5.100

10.  Biosynthesis of thiocarboxylic acid-containing natural products.

Authors:  Liao-Bin Dong; Jeffrey D Rudolf; Dingding Kang; Nan Wang; Cyndi Qixin He; Youchao Deng; Yong Huang; K N Houk; Yanwen Duan; Ben Shen
Journal:  Nat Commun       Date:  2018-06-18       Impact factor: 14.919
  10 in total

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