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Literature DB >> 27598827

A Mild and General Larock Indolization Protocol for the Preparation of Unnatural Tryptophans.

Kangway V Chuang¹, Madeleine E Kieffer¹, Sarah E Reisman¹.

Abstract

A mild and general protocol for the Pd(0)-catalyzed heteroannulation of o-bromoanilines and alkynes is described. Application of a Pd(0)/P((t)Bu)3 catalyst system enables the efficient coupling of o-bromoanilines at 60 °C, mitigating deleterious side reactions and enabling access to a broad range of useful unnatural tryptophans. The utility of this new protocol is demonstrated in the highly convergent total synthesis of the bisindole natural product (-)-aspergilazine A.

Entities: Chemical Gene

Mesh：

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Year: 2016 PMID： 27598827 PMCID： PMC5505074 DOI： 10.1021/acs.orglett.6b02477

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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