Literature DB >> 27596099

Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement.

Damien Noone1,2, Diane Hebert1,2, Christoph Licht3,4,5,6,7.   

Abstract

The antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitides (AAV), although rare in childhood, can have devastating effects on affected organs, especially the kidney. In this review we present an update on the pathogenesis and treatment of ANCA vasculitis, with a particular emphasis on the role of the alternative pathway of complement. The rationale and evidence for the current treatment strategies are summarized. Targeting the activation of neutrophils by the anaphylatoxin C5a may serve as an additional therapeutic strategy, however the results of clinical studies are awaited.

Entities:  

Keywords:  Anti-neutrophil cytoplasm antibody; Children; Eosinophilic granulomatosis with polyangiitis; Granulomatosis with polyangiitis; Microscopic polyangiitis; treatment

Mesh：

Substances：

Year:  2016        PMID： 27596099     DOI： 10.1007/s00467-016-3475-5

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  92 in total

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Journal:  J Am Soc Nephrol       Date:  2010-03-18       Impact factor: 10.121

2.  Long- term outcome of paediatric patients with ANCA vasculitis.

Authors:  Nishkantha Arulkumaran; Susan Jawad; Stuart W Smith; Lorraine Harper; Paul Brogan; Charles D Pusey; Alan D Salama
Journal:  Pediatr Rheumatol Online J       Date:  2011-06-19       Impact factor: 3.054

3.  Interleukin-6 in ANCA-associated vasculitis: Rationale for successful treatment with tocilizumab.

Authors:  Alvise Berti; Giulio Cavalli; Corrado Campochiaro; Barbara Guglielmi; Elena Baldissera; Stefano Cappio; Maria Grazia Sabbadini; Claudio Doglioni; Lorenzo Dagna
Journal:  Semin Arthritis Rheum       Date:  2015-02-20       Impact factor: 5.532

4.  Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.

Authors:  Loïc Guillevin; Christian Pagnoux; Alexandre Karras; Chahera Khouatra; Olivier Aumaître; Pascal Cohen; François Maurier; Olivier Decaux; Jacques Ninet; Pierre Gobert; Thomas Quémeneur; Claire Blanchard-Delaunay; Pascal Godmer; Xavier Puéchal; Pierre-Louis Carron; Pierre-Yves Hatron; Nicolas Limal; Mohamed Hamidou; Maize Ducret; Eric Daugas; Thomas Papo; Bernard Bonnotte; Alfred Mahr; Philippe Ravaud; Luc Mouthon
Journal:  N Engl J Med       Date:  2014-11-06       Impact factor: 91.245

5.  Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils.

Authors:  U Wirthmueller; B Dewald; M Thelen; M K Schäfer; C Stover; K Whaley; J North; P Eggleton; K B Reid; W J Schwaeble
Journal:  J Immunol       Date:  1997-05-01       Impact factor: 5.422

Review 6.  The long-term outcomes of systemic vasculitis.

Authors:  Kerstin Westman; Oliver Flossmann; Gina Gregorini
Journal:  Nephrol Dial Transplant       Date:  2015-01-18       Impact factor: 5.992

7.  Involvement of protein kinase C in C5a-primed neutrophils for ANCA-mediated activation.

Authors:  Jian Hao; Min Chen; Ming-Hui Zhao
Journal:  Mol Immunol       Date:  2012-11-28       Impact factor: 4.407

Review 8.  CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitides.

Authors:  Lucy McGeoch; Marinka Twilt; Leilani Famorca; Volodko Bakowsky; Lillian Barra; Susan M Benseler; David A Cabral; Simon Carette; Gerald P Cox; Navjot Dhindsa; Christine S Dipchand; Aurore Fifi-Mah; Michelle Goulet; Nader Khalidi; Majed M Khraishi; Patrick Liang; Nataliya Milman; Christian A Pineau; Heather N Reich; Nooshin Samadi; Kam Shojania; Regina Taylor-Gjevre; Tanveer E Towheed; Judith Trudeau; Michael Walsh; Elaine Yacyshyn; Christian Pagnoux
Journal:  J Rheumatol       Date:  2015-11-01       Impact factor: 4.666

Review 9.  TNF-α blocker therapy and solid malignancy risk in ANCA-associated vasculitis.

Authors:  Francisco Silva; Marcela Cisternas; Ulrich Specks
Journal:  Curr Rheumatol Rep       Date:  2012-12       Impact factor: 4.592

Review 10.  CanVasc recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides - Executive summary.

Authors:  Lucy McGeoch; Marinka Twilt; Leilani Famorca; Volodko Bakowsky; Lillian Barra; Susan Benseler; David A Cabral; Simon Carette; Gerald P Cox; Navjot Dhindsa; Christine Dipchand; Aurore Fifi-Mah; Michele Goulet; Nader Khalidi; Majed M Khraishi; Patrick Liang; Nataliya Milman; Christian A Pineau; Heather Reich; Nooshin Samadi; Kam Shojania; Regina Taylor-Gjevre; Tanveer E Towheed; Judith Trudeau; Michael Walsh; Elaine Yacyshyn; Christian Pagnoux
Journal:  Can J Kidney Health Dis       Date:  2015-11-09
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  8 in total

Review 1.  Childhood- Versus Adult-Onset Primary Vasculitides: Are They Part of the Same Clinical Spectrum?

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Journal:  Curr Rheumatol Rep       Date:  2019-08-29       Impact factor: 4.592

Review 2.  Anti-neutrophil cytoplasmic antibodies and their clinical significance.

Authors:  Supaporn Suwanchote; Muanpetch Rachayon; Pongsawat Rodsaward; Jongkonnee Wongpiyabovorn; Tawatchai Deekajorndech; Helen L Wright; Steven W Edwards; Michael W Beresford; Pawinee Rerknimitr; Direkrit Chiewchengchol
Journal:  Clin Rheumatol       Date:  2018-03-10       Impact factor: 2.980

3.  Journal Club Review of "Avacopan for the Treatment of ANCA-Associated Vasculitis".

Authors:  William Daniel Soulsby
Journal:  ACR Open Rheumatol       Date:  2022-02-15

4.  Crescentic glomerulonephritis in children.

Authors:  Ulrike Mayer; Jessica Schmitz; Jan Hinrich Bräsen; Lars Pape
Journal:  Pediatr Nephrol       Date:  2020-02-12       Impact factor: 3.714

5.  Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation.

Authors:  Ingrid Lopatko Fagerström; Anne-Lie Ståhl; Maria Mossberg; Ramesh Tati; Ann-Charlotte Kristoffersson; Robin Kahn; Jean-Loup Bascands; Julie Klein; Joost P Schanstra; Mårten Segelmark; Diana Karpman
Journal:  EBioMedicine       Date:  2019-08-20       Impact factor: 8.143

Review 6.  Pituitary Involvement in Granulomatosis with Polyangiitis: A Retrospective Analysis in a Single Chinese Hospital and a Literature Review.

Authors:  Shixuan Liu; Yan Xu; Naishi Li; Shi Chen; Shangzhu Zhang; Linyi Peng; Wei Bai; Jinglan Wang; Jinming Gao; Xiaofeng Zeng; Juhong Shi; Mengzhao Wang
Journal:  Int J Endocrinol       Date:  2019-11-06       Impact factor: 3.257

7.  The Clinical and Pathological Features of Children With Microscopic Polyangiitis.

Authors:  Qian Li; Li-Chun Yu; Feng-Xia Li; Jing Wang; Yuan Chen; Shu-Zhen Sun
Journal:  Front Pediatr       Date:  2021-04-15       Impact factor: 3.418

Review 8.  Beyond Systemic Lupus Erythematosus and Anti-Phospholipid Syndrome: The Relevance of Complement From Pathogenesis to Pregnancy Outcome in Other Systemic Rheumatologic Diseases.

Authors:  Silvia Cavalli; Paola Adele Lonati; Maria Gerosa; Roberto Caporali; Rolando Cimaz; Cecilia Beatrice Chighizola
Journal:  Front Pharmacol       Date:  2022-02-15       Impact factor: 5.810
  8 in total

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