Renato Ferrandiz-Espadin1, Manuel Ferrandiz-Zavaler2. 1. Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430 San Martín de Porres, 15102, Lima, Peru. renato.ferrandiz@upch.pe. 2. Department of Rheumatology, Instituto Nacional de Salud del Niño, Av. Brasil 600, Breña, 15083, Lima, Peru.
Abstract
PURPOSE OF THE REVIEW: Most of the primary vasculitis in children and adults has different clinical manifestations for the same disease, which suggests that they might not be part of the same clinical spectrum and requires a different approach in order to reduce the morbidity and mortality of these patients. In this work, we review the most recent literature and the most important studies that describe and compare adult and children primary vasculitides pathogenesis, clinical presentation, and treatment approach. Accordingly, we discuss recent research involving clinical trials, comparison studies, and pathogeny for these vasculitides. RECENT FINDINGS: Clinical manifestations in the different primary vasculitis change in predominance from adults to children. There is a female sex predominance for the ANCA vasculitides in children compared with adults, but the same treatment works in most cases for both groups. Identifying the diverse clinical spectrum in both adults and children primary vasculitides will reduce the need to extrapolate the diagnostic criteria from one group to another and individualize it, which will allow the clinician to establish a better approach.
PURPOSE OF THE REVIEW: Most of the primary vasculitis in children and adults has different clinical manifestations for the same disease, which suggests that they might not be part of the same clinical spectrum and requires a different approach in order to reduce the morbidity and mortality of these patients. In this work, we review the most recent literature and the most important studies that describe and compare adult and childrenprimary vasculitides pathogenesis, clinical presentation, and treatment approach. Accordingly, we discuss recent research involving clinical trials, comparison studies, and pathogeny for these vasculitides. RECENT FINDINGS: Clinical manifestations in the different primary vasculitis change in predominance from adults to children. There is a female sex predominance for the ANCA vasculitides in children compared with adults, but the same treatment works in most cases for both groups. Identifying the diverse clinical spectrum in both adults and childrenprimary vasculitides will reduce the need to extrapolate the diagnostic criteria from one group to another and individualize it, which will allow the clinician to establish a better approach.
Authors: Jane W Newburger; Masato Takahashi; Michael A Gerber; Michael H Gewitz; Lloyd Y Tani; Jane C Burns; Stanford T Shulman; Ann F Bolger; Patricia Ferrieri; Robert S Baltimore; Walter R Wilson; Larry M Baddour; Matthew E Levison; Thomas J Pallasch; Donald A Falace; Kathryn A Taubert Journal: Circulation Date: 2004-10-26 Impact factor: 29.690
Authors: E Pertuiset; F Lioté; E Launay-Russ; F Kemiche; I Cerf-Payrastre; A M Chesneau Journal: Semin Arthritis Rheum Date: 2000-06 Impact factor: 5.532
Authors: Seza Ozen; Jordi Anton; Nil Arisoy; Aysin Bakkaloglu; Nesrin Besbas; Paul Brogan; Julia García-Consuegra; Pavla Dolezalova; Frank Dressler; Ali Duzova; Virgínia Paes Leme Ferriani; Maria Odete Esteves Hilário; Mercedes Ibáñez-Rubio; Ozgur Kasapcopur; Wietse Kuis; Thomas J A Lehman; Dana Nemcova; Susan Nielsen; Sheila Knupp Oliveira; Kenneth Schikler; Flavio Sztajnbok; Maria Teresa Terreri; Francesco Zulian; Patricia Woo Journal: J Pediatr Date: 2004-10 Impact factor: 4.406