Min Hee Suh1, Linda M Zangwill2, Patricia Isabel C Manalastas2, Akram Belghith2, Adeleh Yarmohammadi2, Felipe A Medeiros2, Alberto Diniz-Filho2, Luke J Saunders2, Siamak Yousefi2, Robert N Weinreb3. 1. Hamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California; Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea. 2. Hamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California. 3. Hamilton Glaucoma Center, Shiley Eye Institute, and the Department of Ophthalmology, University of California San Diego, La Jolla, California. Electronic address: rweinreb@ucsd.edu.
Abstract
PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage. METHODS: Optical coherence tomography (OCT) angiography-derived circumpapillary vessel density (cpVD) was calculated as the percentage area occupied by vessels in the measured region extracted from the retinal nerve fiber layer (RNFL) in a 750-μm-wide elliptical annulus around the disc. Focal LC defects were detected using swept-source OCT images. MAIN OUTCOME MEASURES: Comparison of global and sectoral (eight 45-degree sectors) cpVDs and circumpapillary RNFL (cpRNFL) thicknesses in eyes with and without LC defects. RESULTS: Age, global, and sectoral cpRNFL thicknesses, VF mean deviation (MD) and pattern standard deviation, presence of optic disc hemorrhage, and mean ocular perfusion pressure did not differ between patients with and without LC defects (P > 0.05 for all comparisons). Mean cpVDs of eyes with LC defects were significantly lower than in eyes without a defect globally (52.9%±5.6% vs. 56.8%±7.7%; P = 0.013) and in the inferotemporal (IT) (49.5%±10.3% vs. 56.8%±12.2%; P = 0.004), superotemporal (ST) (54.3%±8.8% vs. 58.8%±9.6%; P = 0.030), and inferonasal (IN) (52.4%±9.0% vs. 57.6%±9.1%; P = 0.009) sectors. Eyes with LC defects in the IT sector (n = 33) had significantly lower cpVDs than eyes without a defect in the corresponding IT and IN sectors (P < 0.05 for all). Eyes with LC defects in the ST sector (n = 19) had lower cpVDs in the ST, IT, and IN sectors (P < 0.05 for all). CONCLUSIONS: In eyes with similar severity of glaucoma, OCT-A-measured vessel density was significantly lower in POAG eyes with focal LC defects than in eyes without an LC defect. Moreover, reduction of vessel density was spatially correlated with the location of the LC defect.
PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage. METHODS: Optical coherence tomography (OCT) angiography-derived circumpapillary vessel density (cpVD) was calculated as the percentage area occupied by vessels in the measured region extracted from the retinal nerve fiber layer (RNFL) in a 750-μm-wide elliptical annulus around the disc. Focal LC defects were detected using swept-source OCT images. MAIN OUTCOME MEASURES: Comparison of global and sectoral (eight 45-degree sectors) cpVDs and circumpapillary RNFL (cpRNFL) thicknesses in eyes with and without LC defects. RESULTS: Age, global, and sectoral cpRNFL thicknesses, VF mean deviation (MD) and pattern standard deviation, presence of optic disc hemorrhage, and mean ocular perfusion pressure did not differ between patients with and without LC defects (P > 0.05 for all comparisons). Mean cpVDs of eyes with LC defects were significantly lower than in eyes without a defect globally (52.9%±5.6% vs. 56.8%±7.7%; P = 0.013) and in the inferotemporal (IT) (49.5%±10.3% vs. 56.8%±12.2%; P = 0.004), superotemporal (ST) (54.3%±8.8% vs. 58.8%±9.6%; P = 0.030), and inferonasal (IN) (52.4%±9.0% vs. 57.6%±9.1%; P = 0.009) sectors. Eyes with LC defects in the IT sector (n = 33) had significantly lower cpVDs than eyes without a defect in the corresponding IT and IN sectors (P < 0.05 for all). Eyes with LC defects in the ST sector (n = 19) had lower cpVDs in the ST, IT, and IN sectors (P < 0.05 for all). CONCLUSIONS: In eyes with similar severity of glaucoma, OCT-A-measured vessel density was significantly lower in POAG eyes with focal LC defects than in eyes without an LC defect. Moreover, reduction of vessel density was spatially correlated with the location of the LC defect.
Authors: Saman Kiumehr; Sung Chul Park; Dorairaj Syril; Christopher C Teng; Celso Tello; Jeffrey M Liebmann; Robert Ritch Journal: Arch Ophthalmol Date: 2012-05
Authors: Sung Chul Park; Anthony T Hsu; Daniel Su; Joseph L Simonson; Mohammed Al-Jumayli; Yiyi Liu; Jeffrey M Liebmann; Robert Ritch Journal: Invest Ophthalmol Vis Sci Date: 2013-12-30 Impact factor: 4.799
Authors: Jae Young You; Sung Chul Park; Daniel Su; Christopher C Teng; Jeffrey M Liebmann; Robert Ritch Journal: JAMA Ophthalmol Date: 2013-03 Impact factor: 7.389
Authors: Yali Jia; Eric Wei; Xiaogang Wang; Xinbo Zhang; John C Morrison; Mansi Parikh; Lori H Lombardi; Devin M Gattey; Rebecca L Armour; Beth Edmunds; Martin F Kraus; James G Fujimoto; David Huang Journal: Ophthalmology Date: 2014-03-12 Impact factor: 12.079
Authors: Omar S Faridi; Sung Chul Park; Rajiv Kabadi; Daniel Su; Carlos Gustavo De Moraes; Jeffrey M Liebmann; Robert Ritch Journal: Ophthalmology Date: 2014-03-31 Impact factor: 12.079
Authors: Adeleh Yarmohammadi; Linda M Zangwill; Alberto Diniz-Filho; Luke J Saunders; Min Hee Suh; Zhichao Wu; Patricia Isabel C Manalastas; Tadamichi Akagi; Felipe A Medeiros; Robert N Weinreb Journal: Ophthalmology Date: 2017-02-10 Impact factor: 12.079
Authors: Patricia I C Manalastas; Linda M Zangwill; Fabio B Daga; Mark A Christopher; Luke J Saunders; Takuhei Shoji; Tadamichi Akagi; Rafaella C Penteado; Adeleh Yarmohammadi; Min H Suh; Felipe A Medeiros; Robert N Weinreb Journal: J Glaucoma Date: 2018-03 Impact factor: 2.503
Authors: Sasan Moghimi; Linda M Zangwill; Patricia Isabel C Manalastas; Min Hee Suh; Rafaella C Penteado; Huiyuan Hou; Kyle Hasenstab; Elham Ghahari; Christopher Bowd; Robert N Weinreb Journal: JAMA Ophthalmol Date: 2019-04-01 Impact factor: 7.389
Authors: Adeleh Yarmohammadi; Linda M Zangwill; Patricia Isabel C Manalastas; Nathanael J Fuller; Alberto Diniz-Filho; Luke J Saunders; Min Hee Suh; Kyle Hasenstab; Robert N Weinreb Journal: Ophthalmology Date: 2017-11-22 Impact factor: 12.079
Authors: Eren Ekici; Sasan Moghimi; Christopher Bowd; Huiyuan Hou; Rafaella C Penteado; James Proudfoot; Diya Yang; Robert N Weinreb Journal: Am J Ophthalmol Date: 2020-06-17 Impact factor: 5.258
Authors: Elham Ghahari; Christopher Bowd; Linda M Zangwill; Min Hee Suh; Takuhei Shoji; Kyle A Hasenstab; Luke J Saunders; Sasan Moghimi; Huiyuan Hou; Patricia I C Manalastas; Rafaella C Penteado; Robert N Weinreb Journal: J Glaucoma Date: 2018-04 Impact factor: 2.503
Authors: Tadamichi Akagi; Linda M Zangwill; Luke J Saunders; Adeleh Yarmohammadi; Patricia Isabel C Manalastas; Min Hee Suh; Christopher A Girkin; Jeffrey M Liebmann; Robert N Weinreb Journal: Ophthalmology Date: 2017-05-09 Impact factor: 12.079
Authors: Huiyuan Hou; Takuhei Shoji; Linda M Zangwill; Sasan Moghimi; Luke J Saunders; Kyle Hasenstab; Elham Ghahari; Patricia Isabel C Manalastas; Tadamichi Akagi; Mark Christopher; Rafaella C Penteado; Robert N Weinreb Journal: Am J Ophthalmol Date: 2018-02-13 Impact factor: 5.258
Authors: Rafaella C Penteado; Linda M Zangwill; Fábio B Daga; Luke J Saunders; Patricia I C Manalastas; Takuhei Shoji; Tadamichi Akagi; Mark Christopher; Adeleh Yarmohammadi; Sasan Moghimi; Robert N Weinreb Journal: J Glaucoma Date: 2018-06 Impact factor: 2.503
Authors: Patricia I C Manalastas; Linda M Zangwill; Luke J Saunders; Kaweh Mansouri; Akram Belghith; Min Hee Suh; Adeleh Yarmohammadi; Rafaella C Penteado; Tadamichi Akagi; Takuhei Shoji; Robert N Weinreb Journal: J Glaucoma Date: 2017-10 Impact factor: 2.503