Literature DB >> 27590469

UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES BIODOSIMETRY AND RADIOLOGICAL/NUCLEAR MEDICAL COUNTERMEASURE PROGRAMS.

Mary J Homer1, Robert Raulli2, Andrea L DiCarlo-Cohen3, John Esker2, Chad Hrdina4, Bert W Maidment3, Brian Moyer2, Carmen Rios3, Francesca Macchiarini3, Pataje G Prasanna5, Lynne Wathen2.   

Abstract

The United States Department of Health and Human Services (HHS) is fully committed to the development of medical countermeasures to address national security threats from chemical, biological, radiological, and nuclear agents. Through the Public Health Emergency Medical Countermeasures Enterprise, HHS has launched and managed a multi-agency, comprehensive effort to develop and operationalize medical countermeasures. Within HHS, development of medical countermeasures includes the National Institutes of Health (NIH), (led by the National Institute of Allergy and Infectious Diseases), the Office of the Assistant Secretary of Preparedness and Response/Biomedical Advanced Research and Development Authority (BARDA); with the Division of Medical Countermeasure Strategy and Requirements, the Centers for Disease Control and Prevention, and the Food and Drug Administration as primary partners in this endeavor. This paper describes various programs and coordinating efforts of BARDA and NIH for the development of medical countermeasures for radiological and nuclear threats. © World Health Organisation 2016. All rights reserved. The World Health Organization has granted Oxford University Press permission for the reproduction of this article.

Entities:  

Mesh:

Year:  2016        PMID: 27590469      PMCID: PMC6280724          DOI: 10.1093/rpd/ncw226

Source DB:  PubMed          Journal:  Radiat Prot Dosimetry        ISSN: 0144-8420            Impact factor:   0.972


  14 in total

1.  Allocation of scarce resources after a nuclear detonation: setting the context.

Authors:  Ann R Knebel; C Norman Coleman; Kenneth D Cliffer; Paula Murrain-Hill; Richard McNally; Victor Oancea; Jimmie Jacobs; Brooke Buddemeier; John L Hick; David M Weinstock; Chad M Hrdina; Tammy Taylor; Marianne Matzo; Judith L Bader; Alicia A Livinski; Gerald Parker; Kevin Yeskey
Journal:  Disaster Med Public Health Prep       Date:  2011-03       Impact factor: 1.385

2.  A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management.

Authors:  Ann M Farese; Melanie V Cohen; Barry P Katz; Cassandra P Smith; William Jackson; Daniel M Cohen; Thomas J MacVittie
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

3.  New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Final rule.

Authors: 
Journal:  Fed Regist       Date:  2002-05-31

4.  Acute gastrointestinal syndrome in high-dose irradiated mice.

Authors:  Catherine Booth; Gregory Tudor; Julie Tudor; Barry P Katz; Thomas J MacVittie
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

5.  Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice.

Authors:  Catherine Booth; Gregory Tudor; Nicola Tonge; Terez Shea-Donohue; Thomas J MacVittie
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

6.  The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model.

Authors:  Thomas J MacVittie; Ann M Farese; Alexander Bennett; Daniel Gelfond; Terez Shea-Donohue; Gregory Tudor; Catherine Booth; Emylee McFarland; William Jackson
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

7.  The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation.

Authors:  Thomas J MacVittie; Alexander Bennett; Catherine Booth; Michael Garofalo; Gregory Tudor; Amanda Ward; Terez Shea-Donohue; Daniel Gelfond; Emylee McFarland; William Jackson; Wei Lu; Ann M Farese
Journal:  Health Phys       Date:  2012-10       Impact factor: 1.316

8.  Assessment of biodosimetry methods for a mass-casualty radiological incident: medical response and management considerations.

Authors:  Julie M Sullivan; Pataje G S Prasanna; Marcy B Grace; Lynne K Wathen; Rodney L Wallace; John F Koerner; C Norman Coleman
Journal:  Health Phys       Date:  2013-12       Impact factor: 1.316

9.  Medical countermeasures against nuclear threats: radionuclide decorporation agents.

Authors:  David R Cassatt; Joseph M Kaminski; Richard J Hatchett; Andrea L DiCarlo; Jessica M Benjamin; Bert W Maidment
Journal:  Radiat Res       Date:  2008-10       Impact factor: 2.841

10.  The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent.

Authors:  Ann M Farese; Cassandra R Brown; Cassandra P Smith; Allison M Gibbs; Barry P Katz; Cynthia S Johnson; Karl L Prado; Thomas J MacVittie
Journal:  Health Phys       Date:  2014-01       Impact factor: 1.316

View more
  14 in total

Review 1.  Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.

Authors:  Evan L Pannkuk; Albert J Fornace; Evagelia C Laiakis
Journal:  Int J Radiat Biol       Date:  2017-01-12       Impact factor: 2.694

2.  Biodosimetry: A Future Tool for Medical Management of Radiological Emergencies.

Authors:  Mary T Sproull; Kevin A Camphausen; Gregory D Koblentz
Journal:  Health Secur       Date:  2017-12-01

Review 3.  Using Stable Free Radicals to Obtain Unique and Clinically Useful Data In Vivo in Human Subjects.

Authors:  Harold M Swartz
Journal:  Radiat Prot Dosimetry       Date:  2016-11-24       Impact factor: 0.972

Review 4.  Saving normal tissues - a goal for the ages.

Authors:  Angela M Groves; Jacqueline P Williams
Journal:  Int J Radiat Biol       Date:  2019-03-29       Impact factor: 2.694

5.  Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation.

Authors:  Prabhat K Purbey; Philip O Scumpia; Peter J Kim; Ann-Jay Tong; Keisuke S Iwamoto; William H McBride; Stephen T Smale
Journal:  Immunity       Date:  2017-09-19       Impact factor: 31.745

Review 6.  Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry.

Authors:  Elena Obrador; Rosario Salvador-Palmer; Juan I Villaescusa; Eduardo Gallego; Blanca Pellicer; José M Estrela; Alegría Montoro
Journal:  Antioxidants (Basel)       Date:  2022-05-31

7.  Small Molecule Signatures of Mice Lacking T-cell p38 Alternate Activation, a Model for Immunosuppression Conditions, after Total-Body Irradiation.

Authors:  Evan L Pannkuk; Evagelia C Laiakis; Jerry Angdisen; Meth M Jayatilake; Pelagie Ake; Lorreta Yun-Tien Lin; Heng-Hong Li; Albert J Fornace
Journal:  Radiat Res       Date:  2022-06-01       Impact factor: 3.372

8.  Scientific research and product development in the United States to address injuries from a radiation public health emergency.

Authors:  Andrea L DiCarlo
Journal:  J Radiat Res       Date:  2021-09-13       Impact factor: 2.724

9.  Dose and Dose-Rate Effects in a Mouse Model of Internal Exposure from 137Cs. Part 2: Integration of Gamma-H2AX and Gene Expression Biomarkers for Retrospective Radiation Biodosimetry.

Authors:  Igor Shuryak; Shanaz A Ghandhi; Helen C Turner; Waylon Weber; Dunstana Melo; Sally A Amundson; David J Brenner
Journal:  Radiat Res       Date:  2020-11-01       Impact factor: 2.841

10.  Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair.

Authors:  Jimmy A Rotolo; Chii Shyang Fong; Sahra Bodo; Prashanth Kb Nagesh; John Fuller; Thivashnee Sharma; Alessandra Piersigilli; Zhigang Zhang; Zvi Fuks; Vijay K Singh; Richard Kolesnick
Journal:  JCI Insight       Date:  2021-04-22
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.