Jingling Chang1,2, Hua Zhang3, Zhongjian Tan4, Juan Xiao3, Shuren Li5, Ying Gao3,6. 1. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China. ear6979@163.com. 2. TCM EncePhaloPathy Treatment, Key Laboratory of Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China. ear6979@163.com. 3. Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China. 4. Department of l radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China. 5. Division of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. 6. TCM EncePhaloPathy Treatment, Key Laboratory of Beijing University of Chinese Medicine, No. 5 Haiyuncang, 100700, Beijing, Dongcheng District, China.
Abstract
BACKGROUND: In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasia patients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied. METHODS: In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis. RESULTS: The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI. CONCLUSIONS: Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.
BACKGROUND: In this study we investigated the neurolinguistic and neuroimaging characteristics of post-stroke motor aphasiapatients. The effects of acupuncture on cortex activation by using magnetic resonance imaging (MRI) in patients with motor aphasia were also studied. METHODS: In this study 43 patients with motor aphasia after stroke were assessed according to Clinical Rehabilitation Research Center aphasia examination (CRRCAE) for linguistic evaluation and MRI and computed tomography (CT) were used for the analyses of brain lesions. The MRI imaging data were also examined using statistical parametric mapping (SPM8) software. Cortex activation images during acupuncture were analyzed using generalized linear model analysis. RESULTS: The results of MRI and CT showed diverse brain lesion regions of post-stroke motor aphasia including the cortex, subcortex and cortex together with the subcortex. The language-related brain areas are activated by acupuncture including frontal, temporal, parietal and occipital lobes as well as insula, precuneus and other wide range of brain function areas as shown by MRI. CONCLUSIONS: Our study showed that the brain lesion regions in post-stroke motor aphasia were not completely consistent with the classical motor speech center. By using MRI our study results suggest that the formation of cognitive language may be involved with the cortical-subcortical functional networks. Acupuncture may be useful for treatment of motor aphasia after stroke.
Entities:
Keywords:
Cerebral cortex; Computed tomography; Magnetic resonance imaging; Stroke; Traditional Chinese medicine
Authors: Argye E Hillis; Melissa Work; Peter B Barker; Michael A Jacobs; Elisabeth L Breese; Kristin Maurer Journal: Brain Date: 2004-04-16 Impact factor: 13.501