Pilar Navarro1, Olaya de Dios1, Teresa Gavela-Pérez2, Asha Jois1, Carmen Garcés3, Leandro Soriano-Guillén2. 1. Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain. 2. Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain; Department of Pediatrics, IIS-Fundacion Jimenez Diaz, Madrid, Spain. 3. Lipid Research Laboratory, IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: cgarces@fjd.es.
Abstract
OBJECTIVES: To analyze the association between high-sensitivity C-reactive protein (hs-CRP) levels and cardiovascular risk factors in healthy school children, and to evaluate whether changes in body mass index (BMI) category throughout childhood affect hs-CRP levels. STUDY DESIGN: We measured serum hs-CRP levels, lipid profile, insulin levels, and leptin levels in 683 prepubertal children and 748 adolescents. A total of 272 children participated in the study in both cohorts, prepubertal (baseline; age 6-8 years) and adolescents (follow-up; age 12-16 years). RESULTS: Compared with their normal weight (NW) counterparts, hs-CRP levels were significantly higher in obese and overweight (OW) adolescents and obese prepubertal children. The highest hs-CRP levels were seen in children who were OW at baseline and at follow-up, and the lowest levels in those who transitioned from OW at baseline to NW at follow-up. High-density lipoprotein cholesterol and apolipoprotein A-I levels decreased across the hs-CRP tertile in both prepubertal children and adolescents, with significant differences (P < .001) in concentrations between the highest and lowest tertiles in 6- to 8-year-old boys and girls and in 12- to 16-year-old boys. The hs-CRP levels were also significantly associated with leptin levels in both prepubertal children and adolescents, with a significant increase across hs-CRP tertiles (P < .001). CONCLUSIONS: The shift from OW to NW throughout childhood is associated with a decrease in hs-CRP level to below that observed in children who maintain NW throughout childhood. Leptin levels were strongly associated with hs-CRP levels in our population independent of BMI. Our findings suggest that an obesity-related chronic inflammatory state may be reversible by improving weight status.
OBJECTIVES: To analyze the association between high-sensitivity C-reactive protein (hs-CRP) levels and cardiovascular risk factors in healthy school children, and to evaluate whether changes in body mass index (BMI) category throughout childhood affect hs-CRP levels. STUDY DESIGN: We measured serum hs-CRP levels, lipid profile, insulin levels, and leptin levels in 683 prepubertal children and 748 adolescents. A total of 272 children participated in the study in both cohorts, prepubertal (baseline; age 6-8 years) and adolescents (follow-up; age 12-16 years). RESULTS: Compared with their normal weight (NW) counterparts, hs-CRP levels were significantly higher in obese and overweight (OW) adolescents and obese prepubertal children. The highest hs-CRP levels were seen in children who were OW at baseline and at follow-up, and the lowest levels in those who transitioned from OW at baseline to NW at follow-up. High-density lipoprotein cholesterol and apolipoprotein A-I levels decreased across the hs-CRP tertile in both prepubertal children and adolescents, with significant differences (P < .001) in concentrations between the highest and lowest tertiles in 6- to 8-year-old boys and girls and in 12- to 16-year-old boys. The hs-CRP levels were also significantly associated with leptin levels in both prepubertal children and adolescents, with a significant increase across hs-CRP tertiles (P < .001). CONCLUSIONS: The shift from OW to NW throughout childhood is associated with a decrease in hs-CRP level to below that observed in children who maintain NW throughout childhood. Leptin levels were strongly associated with hs-CRP levels in our population independent of BMI. Our findings suggest that an obesity-related chronic inflammatory state may be reversible by improving weight status.
Authors: Ernst Mayerhofer; Franz Ratzinger; Nina Elvira Kienreich; Annika Stiel; Nadine Witzeneder; Eva Schrefl; Georg Greiner; Christoph Wegscheider; Irene Graf; Klaus Schmetterer; Rodrig Marculescu; Thomas Szekeres; Thomas Perkmann; Martina Fondi; Oswald Wagner; Harald Esterbauer; Matthias Mayerhofer; Stefana Holocher-Ertl; Claudia Wojnarowski; Gregor Hoermann Journal: Front Pediatr Date: 2020-02-21 Impact factor: 3.418