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Literature DB >> 275841

Amino-terminal sequence analysis of the structural proteins of Sindbis virus.

J R Bell, M W Hunkapiller, L E Hood, J H Strauss.

Abstract

The structural proteins of Sindbis virus, an enveloped virus which belongs to the Togavirus family, have been subjected to automated Edman degradation using improved techniques. Extensive NH2-terminal sequences of about 50 residues were determined for each of the two membrane glycoproteins. In both cases the NH2 terminus of the molecule was found to be similar in composition to typical water-soluble proteins. The viral capsid protein was found to have a blocked alpha-amino group. This is consistent with other observations that viral proteins derived from the NH2 terminus of precursor molecules are often blocked.

Entities: Chemical Species

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Year: 1978 PMID： 275841 PMCID： PMC392635 DOI： 10.1073/pnas.75.6.2722

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

23 in total

Amino-terminal sequence analysis of the structural proteins of Sindbis virus.

1. THE ORIGIN OF THE PROTEIN OF SINDBIS VIRUS.

2. Two disulfide-linked polypeptide chains constitute the active F protein of paramyxoviruses.

Review 3. Proteolytic cleavage events in oncornavirus protein synthesis.

4. Proteolytic cleavage of horse liver cytochrome b5. Primary structure of the heme-containing moiety.

5. Studies on the amphipathic nature of the membrane proteins in Semliki Forest virus.

6. The low polarity of many membrane proteins.

7. Location of the glycoprotein in the membrane of Sindbis virus.

8. Identification of the membrane protein and "core" protein of Sindbis virus.

9. How a single Sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins.

10. Studies on the primary structure of the influenza virus hemagglutinin.

1. Infectious enveloped RNA virus antigenic chimeras.

2. An evolutionary tree relating eight alphaviruses, based on amino-terminal sequences of their glycoproteins.

3. Structural proteins of Western equine encephalitis virus: amino acid compositions and N-terminal sequences.

4. Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.

5. Evidence for covalent attachment of fatty acids to Sindbis virus glycoproteins.

6. Biographical Feature: James H. Strauss, Jr. (1938-2021).

Review 7. Alphavirus Replication: The Role of Cardiac Glycosides and Ion Concentration in Host Cells.

Review 8. Semliki Forest virus: a probe for membrane traffic in the animal cell.