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Literature DB >> 27570565

Nuclear lamins in cancer.

Jerome Irianto¹, Charlotte R Pfeifer¹, Irena L Ivanovska¹, Joe Swift¹, Dennis E Discher¹.

Abstract

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying the main structural proteins of nuclei, the lamins, in cancer. Past studies have also demonstrated the significance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics. Lamin levels can constrain cancer cell migration in 3D and thereby impede tumor growth, and lamins can also protect a cancer cell's genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) and chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.

Entities: Chemical Disease Gene Species

Keywords: LADs; Nuclear lamina; SRF; YAP/TAZ; cancer; homeostasis; mechanotransduction

Year: 2016 PMID： 27570565 PMCID： PMC4999255 DOI： 10.1007/s12195-016-0437-8

Source DB: PubMed Journal: Cell Mol Bioeng ISSN： 1865-5025 Impact factor: 2.321

93 in total

1. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

Authors: P Mohaghegh; J K Karow; R M Brosh; V A Bohr; I D Hickson
Journal: Nucleic Acids Res Date: 2001-07-01 Impact factor: 16.971

2. From laminin to lamin: regulation of tissue-specific gene expression by the ECM.

Authors: N Boudreau; C Myers; M J Bissell
Journal: Trends Cell Biol Date: 1995-01 Impact factor: 20.808

3. Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.

Authors: Laura Moro; Laura Dolce; Sara Cabodi; Elena Bergatto; Elisabetta Boeri Erba; Monica Smeriglio; Emilia Turco; Saverio Francesco Retta; Maria Gabriella Giuffrida; Mascia Venturino; Jasminka Godovac-Zimmermann; Amedeo Conti; Erik Schaefer; Laura Beguinot; Carlo Tacchetti; Paolo Gaggini; Lorenzo Silengo; Guido Tarone; Paola Defilippi
Journal: J Biol Chem Date: 2001-12-27 Impact factor: 5.157

4. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation.

Authors: Dan Constantinescu; Heather L Gray; Paul J Sammak; Gerald P Schatten; Antonei B Csoka
Journal: Stem Cells Date: 2005-09-22 Impact factor: 6.277

5. Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.

Authors: Ruben Agrelo; Fernando Setien; Jesus Espada; Maria Jesus Artiga; Maria Rodriguez; Alberto Pérez-Rosado; Abel Sanchez-Aguilera; Mario F Fraga; Miguel Angel Piris; Manel Esteller
Journal: J Clin Oncol Date: 2005-05-02 Impact factor: 44.544

6. Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms.

Authors: S F Moss; V Krivosheyev; A de Souza; K Chin; H P Gaetz; N Chaudhary; H J Worman; P R Holt
Journal: Gut Date: 1999-11 Impact factor: 23.059

7. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma.

Authors: C M L J Tilli; F C S Ramaekers; J L V Broers; C J Hutchison; H A M Neumann
Journal: Br J Dermatol Date: 2003-01 Impact factor: 9.302

8. Differential expression of nuclear lamins in normal and cancerous prostate tissues.

Authors: Rosella Coradeghini; Paola Barboro; Alessandra Rubagotti; Francesco Boccardo; Silvio Parodi; Giorgio Carmignani; Cristina D'Arrigo; Eligio Patrone; Cecilia Balbi
Journal: Oncol Rep Date: 2006-03 Impact factor: 3.906

9. Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

Authors: Jos L V Broers; Emiel A G Peeters; Helma J H Kuijpers; Jorike Endert; Carlijn V C Bouten; Cees W J Oomens; Frank P T Baaijens; Frans C S Ramaekers
Journal: Hum Mol Genet Date: 2004-09-14 Impact factor: 6.150

10. Expression of individual lamins in basal cell carcinomas of the skin.

Authors: R S Venables; S McLean; D Luny; E Moteleb; S Morley; R A Quinlan; E B Lane; C J Hutchison
Journal: Br J Cancer Date: 2001-02 Impact factor: 7.640

50 in total

Review 1. Causes and consequences of nuclear envelope alterations in tumour progression.

Authors: Emily S Bell; Jan Lammerding
Journal: Eur J Cell Biol Date: 2016-06-25 Impact factor: 4.492

2. Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration.

Authors: Charlotte R Pfeifer; Cory M Alvey; Jerome Irianto; Dennis E Discher
Journal: Curr Opin Syst Biol Date: 2017-04-27

Nuclear lamins in cancer.

1. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

2. From laminin to lamin: regulation of tissue-specific gene expression by the ECM.

3. Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.

4. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation.

5. Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.

6. Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms.

7. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma.

8. Differential expression of nuclear lamins in normal and cancerous prostate tissues.

9. Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

10. Expression of individual lamins in basal cell carcinomas of the skin.

Review 1. Causes and consequences of nuclear envelope alterations in tumour progression.

2. Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration.

3. Mkl1-dependent gene activation is sufficient to induce actin cap assembly.

Review 4. The structure of lamin filaments in somatic cells as revealed by cryo-electron tomography.

5. Nuclear mechanosensing.

6. Lamin A/C promotes DNA base excision repair.

Review 7. Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability?

Review 8. Advances in the computational and molecular understanding of the prostate cancer cell nucleus.

9. Random Motion of Chromatin Is Influenced by Lamin A Interconnections.

10. Nuclear Lamin Protein C Is Linked to Lineage-Specific, Whole-Cell Mechanical Properties.