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Literature DB >> 27550348

Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops.

Chin Fen Neoh^1,2, Lok Leung³, Elsie Chan⁴, Daoud Al-Badriyeh⁵, Robert O Fullinfaw⁶, Vishal Jhanji^4,7, Rasik B Vajpayee⁴, Geoffrey E Davies^3,8, Kay Stewart², David C M Kong⁹.

Abstract

Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2016 PMID： 27550348 PMCID： PMC5075102 DOI： 10.1128/AAC.00683-16

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Voriconazole in the management of Alternaria keratitis.

Authors: Zeynep Ozbek; Sheila Kang; Jocelyn Sivalingam; Christopher J Rapuano; Elisabeth J Cohen; Kristin M Hammersmith
Journal: Cornea Date: 2006-02 Impact factor: 2.651

2. Prospective open-label study of the administration of two-percent voriconazole eye drops.

Authors: Daoud Al-Badriyeh; Lok Leung; Trent Roydhouse; Robert Fullinfaw; Mark Daniell; Geoffrey E Davies; Kay Stewart; David C M Kong
Journal: Antimicrob Agents Chemother Date: 2009-05-11 Impact factor: 5.191

3. Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.

Authors: Michael A Thiel; Annelies S Zinkernagel; Jürgen Burhenne; Claude Kaufmann; Walter E Haefeli
Journal: Antimicrob Agents Chemother Date: 2006-10-23 Impact factor: 5.191

Review 4. Pharmacoeconomics of voriconazole in the management of invasive fungal infections.

Authors: Daoud Al-Badriyeh; Siow Chin Heng; Chin Fen Neoh; Monica Slavin; Kay Stewart; David C M Kong
Journal: Expert Rev Pharmacoecon Outcomes Res Date: 2010-12 Impact factor: 2.217

5. Single and multidose ocular kinetics and stability analysis of extemporaneous formulation of topical voriconazole in humans.

Authors: Srinivasan Senthilkumari; Prajna Lalitha; Namperumalsamy Venkatesh Prajna; Aravind Haripriya; Jeyabalan Nirmal; Pankaj Gupta; Thirumurthy Velpandian
Journal: Curr Eye Res Date: 2010-11 Impact factor: 2.424

Review 6. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in South India.

Authors: Usha Gopinathan; Prashant Garg; Merle Fernandes; Savitri Sharma; Sreedharan Athmanathan; Gullapalli N Rao
Journal: Cornea Date: 2002-08 Impact factor: 2.651

Review 7. Fungal infections of the cornea.

Authors: P A Thomas
Journal: Eye (Lond) Date: 2003-11 Impact factor: 3.775

Review 2. Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement.

Authors: Richard H Drew; John R Perfect
Journal: J Fungi (Basel) Date: 2022-02-21

2 in total

Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops.

1. Voriconazole in the management of Alternaria keratitis.

2. Prospective open-label study of the administration of two-percent voriconazole eye drops.

3. Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.

Review 4. Pharmacoeconomics of voriconazole in the management of invasive fungal infections.

5. Single and multidose ocular kinetics and stability analysis of extemporaneous formulation of topical voriconazole in humans.

Review 6. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in South India.

Review 7. Fungal infections of the cornea.

8. Penetration of voriconazole, 1%, eyedrops into human aqueous humor: a prospective open-label study.

9. Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans.

10. Design and Evaluation of Voriconazole Eye Drops for the Treatment of Fungal Keratitis.

1. Physical, chemical, and microbiological stability study of diluted atropine eye drops.

Review 2. Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement.