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Literature DB >> 19433565

Prospective open-label study of the administration of two-percent voriconazole eye drops.

Daoud Al-Badriyeh¹, Lok Leung, Trent Roydhouse, Robert Fullinfaw, Mark Daniell, Geoffrey E Davies, Kay Stewart, David C M Kong.

Abstract

Thirteen human subjects scheduled for elective anterior segment eye surgery received hourly 2% voriconazole eye drops 4 hours presurgery. No side effects were reported. Significantly, the voriconazole concentration in the aqueous humor of the eye was similar to that reported for the 1% voriconazole solution, suggestive of concentration-independent absorption.

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Year: 2009 PMID： 19433565 PMCID： PMC2704690 DOI： 10.1128/AAC.01700-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

13 in total

1. Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.

Authors: Rocus R Klont; Cathrien A Eggink; Antonius J M M Rijs; Pieter Wesseling; Paul E Verweij
Journal: Clin Infect Dis Date: 2005-05-12 Impact factor: 9.079

Review 2. Mechanism of fluid transport across corneal endothelium and other epithelial layers: a possible explanation based on cyclic cell volume regulatory changes.

Authors: J Fischbarg
Journal: Br J Ophthalmol Date: 1997-01 Impact factor: 4.638

3. Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.

Authors: Michael A Thiel; Annelies S Zinkernagel; Jürgen Burhenne; Claude Kaufmann; Walter E Haefeli
Journal: Antimicrob Agents Chemother Date: 2006-10-23 Impact factor: 5.191

Prospective open-label study of the administration of two-percent voriconazole eye drops.

1. Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.

Review 2. Mechanism of fluid transport across corneal endothelium and other epithelial layers: a possible explanation based on cyclic cell volume regulatory changes.

3. Voriconazole concentration in human aqueous humor and plasma during topical or combined topical and systemic administration for fungal keratitis.

4. Management of endogenous fungal endophthalmitis with voriconazole and caspofungin.

5. Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses.

6. Effect of voriconazole on a corneal abscess caused by fusarium.

7. Safety of intravitreal voriconazole: electroretinographic and histopathologic studies.

8. Penetration of voriconazole, 1%, eyedrops into human aqueous humor: a prospective open-label study.

9. Fungal keratitis in Melbourne.

10. Stability of cefazolin sodium eye drops.

1. Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops.

2. Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis.

3. A case of infectious crystalline keratopathy after corneal cross-linking.