| Literature DB >> 27509303 |
Qingjie Wang1, Hui Yang1, Aobing Bai1, Wei Jiang1, Xiuya Li1, Xinhong Wang1, Yishen Mao1, Chao Lu1, Ruizhe Qian1, Feng Guo2, Tianling Ding3, Haiyan Chen4, Sifeng Chen1, Jianyi Zhang5, Chen Liu6, Ning Sun7.
Abstract
With the advent of induced pluripotent stem cells and directed differentiation techniques, it is now feasible to derive individual-specific cardiac cells for human heart tissue engineering. Here we report the generation of functional engineered human cardiac patches using human induced pluripotent stem cells-derived cardiac cells and decellularized natural heart ECM as scaffolds. The engineered human cardiac patches can be tailored to any desired size and shape and exhibited normal contractile and electrical physiology in vitro. Further, when patching on the infarct area, these patches improved heart function of rats with acute myocardial infarction in vivo. These engineered human cardiac patches can be of great value for normal and disease-specific heart tissue engineering, drug screening, and meet the demands for individual-specific heart tissues for personalized regenerative therapy of myocardial damages in the future.Entities:
Keywords: Cardiac patch; Cardiomyocytes; Decellularized heart matrix; Engineering human heart tissue; Induced pluripotent stem cells; Myocardial infarction
Mesh：
Year: 2016 PMID： 27509303 DOI： 10.1016/j.biomaterials.2016.07.035
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479