| Literature DB >> 27508870 |
Kong Y Chen1, Aaron M Cypess2, Maren R Laughlin3, Carol R Haft4, Houchun Harry Hu5, Miriam A Bredella6, Sven Enerbäck7, Paul E Kinahan8, Wouter van Marken Lichtenbelt9, Frank I Lin10, John J Sunderland11, Kirsi A Virtanen12, Richard L Wahl13.
Abstract
Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked. Published by Elsevier Inc.Entities:
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Year: 2016 PMID： 27508870 PMCID： PMC4981083 DOI： 10.1016/j.cmet.2016.07.014
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287