| Literature DB >> 26235421 |
Evie P M Broeders1, Emmani B M Nascimento2, Bas Havekes3, Boudewijn Brans4, Kay H M Roumans2, Anne Tailleux5, Gert Schaart2, Mostafa Kouach6, Julie Charton7, Benoit Deprez7, Nicole D Bouvy8, Felix Mottaghy9, Bart Staels5, Wouter D van Marken Lichtenbelt2, Patrick Schrauwen10.
Abstract
The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodothyronine deiodinase (D2) in BAT via the G-coupled protein receptor TGR5, resulting in increased oxygen consumption and energy expenditure. Here we examined the effects of oral supplementation of the bile acid chenodeoxycholic acid (CDCA) on human BAT activity. Treatment of 12 healthy female subjects with CDCA for 2 days resulted in increased BAT activity. Whole-body energy expenditure was also increased upon CDCA treatment. In vitro treatment of primary human brown adipocytes derived with CDCA or specific TGR5 agonists increased mitochondrial uncoupling and D2 expression, an effect that was absent in human primary white adipocytes. These findings identify bile acids as a target to activate BAT in humans.Entities:
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Year: 2015 PMID： 26235421 DOI： 10.1016/j.cmet.2015.07.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287