Borja Martinez-Tellez1,2, Guillermo Sanchez-Delgado3, Mariëtte R Boon4, Patrick C N Rensen4, José M Llamas-Elvira5,6, Jonatan R Ruiz3. 1. PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Crta de Alfacar s/n, C.P. 18071, Granada, Spain. borjammt@gmail.com. 2. Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. borjammt@gmail.com. 3. PROFITH "PROmoting FITness and Health through physical activity" research group. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Crta de Alfacar s/n, C.P. 18071, Granada, Spain. 4. Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. 5. Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spain. 6. Servicio de Medicina Nuclear, Instituto de Investigación Biosanitaria (ibs. GRANADA), Granada, Spain.
Abstract
PURPOSE: Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore, the main objective of the present study is (i) to examine the influence of SUV and HU thresholds on BAT quantification by [18F]FDG-PET/CT scan, (ii) to identify the proportion of BAT which is not detected by [18F]FDG-PET/CT scan when limiting the range between - 10 and - 50 HU, and (iii) to describe the distribution of BAT radiodensity by weight status and sex in young healthy individuals. PROCEDURES: We measured 125 individuals after a personalized cooling protocol with a static [18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every single HU for all participants. RESULTS: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/CT scans more than the HU range. We found that the range from - 50 to - 10 HU had the highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT metabolic activity in our cohort. We also observed that BAT volume was not different between categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the range from - 50 to - 10 HU. CONCLUSION: Therefore, all future human studies using static [18F]FDG-PET/CT scans should include BAT in the radiodensity range from - 50 to - 10 HU.
PURPOSE: Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore, the main objective of the present study is (i) to examine the influence of SUV and HU thresholds on BAT quantification by [18F]FDG-PET/CT scan, (ii) to identify the proportion of BAT which is not detected by [18F]FDG-PET/CT scan when limiting the range between - 10 and - 50 HU, and (iii) to describe the distribution of BAT radiodensity by weight status and sex in young healthy individuals. PROCEDURES: We measured 125 individuals after a personalized cooling protocol with a static [18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every single HU for all participants. RESULTS: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/CT scans more than the HU range. We found that the range from - 50 to - 10 HU had the highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT metabolic activity in our cohort. We also observed that BAT volume was not different between categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the range from - 50 to - 10 HU. CONCLUSION: Therefore, all future human studies using static [18F]FDG-PET/CT scans should include BAT in the radiodensity range from - 50 to - 10 HU.
Entities:
Keywords:
Brown fat; Cold exposure; Hounsfield units; Standardized uptake value
Authors: Kyle Gordon; Denis P Blondin; Brian J Friesen; Hans Christian Tingelstad; Glen P Kenny; François Haman Journal: J Appl Physiol (1985) Date: 2019-03-21
Authors: Johannes Schindelin; Ignacio Arganda-Carreras; Erwin Frise; Verena Kaynig; Mark Longair; Tobias Pietzsch; Stephan Preibisch; Curtis Rueden; Stephan Saalfeld; Benjamin Schmid; Jean-Yves Tinevez; Daniel James White; Volker Hartenstein; Kevin Eliceiri; Pavel Tomancak; Albert Cardona Journal: Nat Methods Date: 2012-06-28 Impact factor: 28.547
Authors: Y Iris Chen; Aaron M Cypess; Christina A Sass; Anna-Liisa Brownell; Kimmo T Jokivarsi; C Ronald Kahn; Kenneth K Kwong Journal: Obesity (Silver Spring) Date: 2012-02-20 Impact factor: 5.002
Authors: Mark J W Hanssen; Roel Wierts; Joris Hoeks; Anne Gemmink; Boudewijn Brans; Felix M Mottaghy; Patrick Schrauwen; Wouter D van Marken Lichtenbelt Journal: Diabetologia Date: 2014-12-13 Impact factor: 10.122
Authors: Denis P Blondin; Sébastien M Labbé; Christophe Noll; Margaret Kunach; Serge Phoenix; Brigitte Guérin; Éric E Turcotte; François Haman; Denis Richard; André C Carpentier Journal: Diabetes Date: 2015-02-12 Impact factor: 9.461
Authors: Aaron M Cypess; Andrew P White; Cecile Vernochet; Tim J Schulz; Ruidan Xue; Christina A Sass; Tian Liang Huang; Carla Roberts-Toler; Lauren S Weiner; Cathy Sze; Aron T Chacko; Laura N Deschamps; Lindsay M Herder; Nathan Truchan; Allison L Glasgow; Ashley R Holman; Alina Gavrila; Per-Olof Hasselgren; Marcelo A Mori; Michael Molla; Yu-Hua Tseng Journal: Nat Med Date: 2013-04-21 Impact factor: 53.440
Authors: Borja Martinez-Tellez; Guillermo Sanchez-Delgado; Francisco M Acosta; Juan M A Alcantara; Francisco J Amaro-Gahete; Wendy D Martinez-Avila; Elisa Merchan-Ramirez; Victoria Muñoz-Hernandez; Francisco J Osuna-Prieto; Lucas Jurado-Fasoli; Huiwen Xu; Lourdes Ortiz-Alvarez; María J Arias-Tellez; Andrea Mendez-Gutierrez; Idoia Labayen; Francisco B Ortega; Milena Schönke; Patrick C N Rensen; Concepción M Aguilera; José M Llamas-Elvira; Ángel Gil; Jonatan R Ruiz Journal: Nat Commun Date: 2022-09-12 Impact factor: 17.694
Authors: Lucas Jurado-Fasoli; Xinyu Di; Isabelle Kohler; Francisco J Osuna-Prieto; Thomas Hankemeier; Elke Krekels; Amy C Harms; Wei Yang; Jose V Garcia-Lario; Sonia Fernández-Veledo; Jonatan R Ruiz; Patrick C N Rensen; Borja Martinez-Tellez Journal: Obesity (Silver Spring) Date: 2021-12-12 Impact factor: 9.298