Douglas I Walker1, Col Timothy M Mallon, Philip K Hopke, Karan Uppal, Young-Mi Go, Patricia Rohrbeck, Kurt D Pennell, Dean P Jones. 1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Mr Walker, Drs Uppal, Go, Jones); Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts (Mr Walker, Dr Pennell); Professor, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 (Dr Mallon); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke); and 779th Aerospace Medicine Squadron, 79th Medical Wing, Joint Base Andrews, MD (Dr Rohrbeck).
Abstract
OBJECTIVE: The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. METHODS: HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system. RESULTS: Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes. CONCLUSIONS: Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.
OBJECTIVE: The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. METHODS: HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system. RESULTS: Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes. CONCLUSIONS: Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.
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Authors: Danitsja M van Leeuwen; Ralph W H Gottschalk; Greet Schoeters; Nicolas A van Larebeke; Vera Nelen; Willy F Baeyens; Jos C S Kleinjans; Joost H M van Delft Journal: Environ Health Perspect Date: 2008-06-23 Impact factor: 9.031
Authors: Matthew Ryan Smith; Zachery R Jarrell; Michael Orr; Ken H Liu; Young-Mi Go; Dean P Jones Journal: Environ Int Date: 2020-12-21 Impact factor: 9.621
Authors: Jolyn Fernandes; Joshua D Chandler; Ken H Liu; Karan Uppal; Young-Mi Go; Dean P Jones Journal: Food Chem Toxicol Date: 2018-04-21 Impact factor: 6.023
Authors: Young-Mi Go; Matthew R Smith; Douglas I Walker; Karan Uppal; Patricia Rohrbeck; Pamela L Krahl; Philip K Hopke; Mark J Utell; Timothy M Mallon; Dean P Jones Journal: J Occup Environ Med Date: 2019-12 Impact factor: 2.162
Authors: Thomas H Thatcher; Collynn F Woeller; Juilee Thakar; Atif Khan; Philip K Hopke; Matthew Ryan Smith; Karan Uppal; Douglas I Walker; Young-Mi Go; Dean P Jones; Pamela L Krahl; Timothy M Mallon; Patricia J Sime; Richard P Phipps; Mark J Utell Journal: J Occup Environ Med Date: 2019-12 Impact factor: 2.162
Authors: Juilee Thakar; Thomas H Thatcher; Matthew Ryan Smith; Collynn F Woeller; Douglas I Walker; Mark J Utell; Philip K Hopke; Timothy M Mallon; Pamela L Krahl; Patricia Rohrbeck; Young-Mi Go; Dean P Jones; Karan Uppal Journal: J Occup Environ Med Date: 2019-12 Impact factor: 2.162
Authors: Matthew Ryan Smith; Douglas I Walker; Karan Uppal; Mark J Utell; Philip K Hopke; Timothy M Mallon; Pamela L Krahl; Patricia Rohrbeck; Young-Mi Go; Dean P Jones Journal: J Occup Environ Med Date: 2019-12 Impact factor: 2.162
Authors: Collynn F Woeller; Thomas H Thatcher; Juilee Thakar; Adam Cornwell; Matthew R Smith; Dean P Jones; Philip K Hopke; Patricia J Sime; Pamela Krahl; Timothy M Mallon; Richard P Phipps; Mark J Utell Journal: J Occup Environ Med Date: 2019-12 Impact factor: 2.162
Authors: Douglas I Walker; Kayla Perry-Walker; Richard H Finnell; Kurt D Pennell; Vilinh Tran; Ryan C May; Thomas F McElrath; Kimford J Meador; Page B Pennell; Dean P Jones Journal: Toxicol Appl Pharmacol Date: 2018-12-04 Impact factor: 4.219