Literature DB >> 27478159

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

Xavier Rovira1, Ana Trapero2, Silvia Pittolo3, Charleine Zussy1, Adèle Faucherre1, Chris Jopling1, Jesús Giraldo4, Jean-Philippe Pin1, Pau Gorostiza5, Cyril Goudet6, Amadeu Llebaria7.   

Abstract

OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27478159     DOI： 10.1016/j.chembiol.2016.06.013

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  21 in total

1.  Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology.

Authors:  Silvia Pittolo; Hyojung Lee; Anna Lladó; Sébastien Tosi; Miquel Bosch; Lídia Bardia; Xavier Gómez-Santacana; Amadeu Llebaria; Eduardo Soriano; Julien Colombelli; Kira E Poskanzer; Gertrudis Perea; Pau Gorostiza
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-13       Impact factor: 11.205

Review 2.  Synapses in the spotlight with synthetic optogenetics.

Authors:  Shai Berlin; Ehud Y Isacoff
Journal:  EMBO Rep       Date:  2017-04-10       Impact factor: 8.807

Review 3.  Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.

Authors:  Daniel J Foster; P Jeffrey Conn
Journal:  Neuron       Date:  2017-05-03       Impact factor: 17.173

Review 4.  Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits.

Authors:  Skylar M Spangler; Michael R Bruchas
Journal:  Curr Opin Pharmacol       Date:  2016-11-19       Impact factor: 5.547

Review 5.  Precise modulation of neuronal activity with synthetic photoswitchable ligands.

Authors:  Michael A Kienzler; Ehud Y Isacoff
Journal:  Curr Opin Neurobiol       Date:  2017-07-06       Impact factor: 6.627

Review 6.  Orthogonal Control of Neuronal Circuits and Behavior Using Photopharmacology.

Authors:  Rossella Castagna; Dušan Kolarski; Romain Durand-de Cuttoli; Galyna Maleeva
Journal:  J Mol Neurosci       Date:  2022-06-23       Impact factor: 2.866

7.  Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.

Authors:  Marco Paolino; Mariagrazia Rullo; Samuele Maramai; Modesto de Candia; Leonardo Pisani; Marco Catto; Claudia Mugnaini; Antonella Brizzi; Andrea Cappelli; Massimo Olivucci; Federico Corelli; Cosimo D Altomare
Journal:  RSC Med Chem       Date:  2022-06-01

Review 8.  Optical control of neuronal ion channels and receptors.

Authors:  Pierre Paoletti; Graham C R Ellis-Davies; Alexandre Mourot
Journal:  Nat Rev Neurosci       Date:  2019-09       Impact factor: 34.870

Review 9.  Silencing Neurons: Tools, Applications, and Experimental Constraints.

Authors:  J Simon Wiegert; Mathias Mahn; Matthias Prigge; Yoav Printz; Ofer Yizhar
Journal:  Neuron       Date:  2017-08-02       Impact factor: 17.173

10.  Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor.

Authors:  Prashant Donthamsetti; David B Konrad; Belinda Hetzler; Zhu Fu; Dirk Trauner; Ehud Y Isacoff
Journal:  J Am Chem Soc       Date:  2021-06-11       Impact factor: 15.419
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