Literature DB >> 27467916

Frameshift mutations, neoantigens and tumor-specific CD8(+) T cells in microsatellite unstable colorectal cancers.

Pauline Maby1, Jérôme Galon2, Jean-Baptiste Latouche3.   

Abstract

Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8(+) T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.

Entities:  

Keywords:  Adoptive cell transfer; colorectal cancer; frameshift mutation; immunotherapy; microsatellite instablility; neoantigen; neopeptide; tumor-specific CD8+ T cell

Year:  2015        PMID： 27467916      PMCID： PMC4910722          DOI： 10.1080/2162402X.2015.1115943

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  11 in total

1.  Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy.

Authors:  Pauline Maby; David Tougeron; Mohamad Hamieh; Bernhard Mlecnik; Hafid Kora; Gabriela Bindea; Helen K Angell; Tessa Fredriksen; Nicolas Elie; Emilie Fauquembergue; Aurélie Drouet; Jérôme Leprince; Jacques Benichou; Jacques Mauillon; Florence Le Pessot; Richard Sesboüé; Jean-Jacques Tuech; Jean-Christophe Sabourin; Pierre Michel; Thierry Frébourg; Jérôme Galon; Jean-Baptiste Latouche
Journal:  Cancer Res       Date:  2015-06-09       Impact factor: 12.701

2.  Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells.

Authors:  J B Latouche; M Sadelain
Journal:  Nat Biotechnol       Date:  2000-04       Impact factor: 54.908

3.  Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Authors:  Bernhard Mlecnik; Gabriela Bindea; Helen K Angell; Pauline Maby; Mihaela Angelova; David Tougeron; Sarah E Church; Lucie Lafontaine; Maria Fischer; Tessa Fredriksen; Maristella Sasso; Amélie M Bilocq; Amos Kirilovsky; Anna C Obenauf; Mohamad Hamieh; Anne Berger; Patrick Bruneval; Jean-Jacques Tuech; Jean-Christophe Sabourin; Florence Le Pessot; Jacques Mauillon; Arash Rafii; Pierre Laurent-Puig; Michael R Speicher; Zlatko Trajanoski; Pierre Michel; Richard Sesboüe; Thierry Frebourg; Franck Pagès; Viia Valge-Archer; Jean-Baptiste Latouche; Jérôme Galon
Journal:  Immunity       Date:  2016-03-15       Impact factor: 31.745

4.  Frameshift peptide-derived T-cell epitopes: a source of novel tumor-specific antigens.

Authors:  M Linnebacher; J Gebert; W Rudy; S Woerner; Y P Yuan; P Bork; M von Knebel Doeberitz
Journal:  Int J Cancer       Date:  2001-07-01       Impact factor: 7.396

5.  PD-1 Blockade in Tumors with Mismatch-Repair Deficiency.

Authors:  Dung T Le; Jennifer N Uram; Hao Wang; Bjarne R Bartlett; Holly Kemberling; Aleksandra D Eyring; Andrew D Skora; Brandon S Luber; Nilofer S Azad; Dan Laheru; Barbara Biedrzycki; Ross C Donehower; Atif Zaheer; George A Fisher; Todd S Crocenzi; James J Lee; Steven M Duffy; Richard M Goldberg; Albert de la Chapelle; Minori Koshiji; Feriyl Bhaijee; Thomas Huebner; Ralph H Hruban; Laura D Wood; Nathan Cuka; Drew M Pardoll; Nickolas Papadopoulos; Kenneth W Kinzler; Shibin Zhou; Toby C Cornish; Janis M Taube; Robert A Anders; James R Eshleman; Bert Vogelstein; Luis A Diaz
Journal:  N Engl J Med       Date:  2015-05-30       Impact factor: 91.245

Review 6.  The immune contexture in human tumours: impact on clinical outcome.

Authors:  Wolf Herman Fridman; Franck Pagès; Catherine Sautès-Fridman; Jérôme Galon
Journal:  Nat Rev Cancer       Date:  2012-03-15       Impact factor: 60.716

7.  The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.

Authors:  Nicolas J Llosa; Michael Cruise; Ada Tam; Elizabeth C Wicks; Elizabeth M Hechenbleikner; Janis M Taube; Richard L Blosser; Hongni Fan; Hao Wang; Brandon S Luber; Ming Zhang; Nickolas Papadopoulos; Kenneth W Kinzler; Bert Vogelstein; Cynthia L Sears; Robert A Anders; Drew M Pardoll; Franck Housseau
Journal:  Cancer Discov       Date:  2014-10-30       Impact factor: 39.397

8.  Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status.

Authors:  J M Michael-Robinson; A Biemer-Hüttmann; D M Purdie; M D Walsh; L A Simms; K G Biden; J P Young; B A Leggett; J R Jass; G L Radford-Smith
Journal:  Gut       Date:  2001-03       Impact factor: 23.059

9.  Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.

Authors:  David Tougeron; Emilie Fauquembergue; Alexandre Rouquette; Florence Le Pessot; Richard Sesboüé; Michèle Laurent; Pascaline Berthet; Jacques Mauillon; Frédéric Di Fiore; Jean-Christophe Sabourin; Pierre Michel; Mario Tosi; Thierry Frébourg; Jean-Baptiste Latouche
Journal:  Mod Pathol       Date:  2009-06-05       Impact factor: 7.842

10.  Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic.

Authors:  S M Phillips; A Banerjea; R Feakins; S R Li; S A Bustin; S Dorudi
Journal:  Br J Surg       Date:  2004-04       Impact factor: 6.939
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  17 in total

Review 1.  Trial watch: Immune checkpoint blockers for cancer therapy.

Authors:  Claire Vanpouille-Box; Claire Lhuillier; Lucillia Bezu; Fernando Aranda; Takahiro Yamazaki; Oliver Kepp; Jitka Fucikova; Radek Spisek; Sandra Demaria; Silvia C Formenti; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-08-31       Impact factor: 8.110

Review 2.  Trial watch: DNA-based vaccines for oncological indications.

Authors:  Stefano Pierini; Renzo Perales-Linares; Mireia Uribe-Herranz; Jonathan G Pol; Laurence Zitvogel; Guido Kroemer; Andrea Facciabene; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-11-20       Impact factor: 8.110

3.  Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCMin/+ mice.

Authors:  Louis Szeponik; Paulina Akeus; William Rodin; Sukanya Raghavan; Marianne Quiding-Järbrink
Journal:  Cancer Immunol Immunother       Date:  2020-03-17       Impact factor: 6.968

4.  Immune overdrive signature in colorectal tumor subset predicts poor clinical outcome.

Authors:  Marwan Fakih; Ching Ouyang; Chongkai Wang; Travis Yiwey Tu; Maricel C Gozo; May Cho; Marvin Sy; Jeffrey A Longmate; Peter P Lee
Journal:  J Clin Invest       Date:  2019-10-01       Impact factor: 14.808

5.  DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells.

Authors:  Jiil Chung; Yosef E Maruvka; Gad Getz; Uri Tabori; Sumedha Sudhaman; Jacalyn Kelly; Nicholas J Haradhvala; Vanessa Bianchi; Melissa Edwards; Victoria J Forster; Nuno M Nunes; Melissa A Galati; Martin Komosa; Shriya Deshmukh; Vanja Cabric; Scott Davidson; Matthew Zatzman; Nicholas Light; Reid Hayes; Ledia Brunga; Nathaniel D Anderson; Ben Ho; Karl P Hodel; Robert Siddaway; A Sorana Morrissy; Daniel C Bowers; Valérie Larouche; Annika Bronsema; Michael Osborn; Kristina A Cole; Enrico Opocher; Gary Mason; Gregory A Thomas; Ben George; David S Ziegler; Scott Lindhorst; Magimairajan Vanan; Michal Yalon-Oren; Alyssa T Reddy; Maura Massimino; Patrick Tomboc; An Van Damme; Alexander Lossos; Carol Durno; Melyssa Aronson; Daniel A Morgenstern; Eric Bouffet; Annie Huang; Michael D Taylor; Anita Villani; David Malkin; Cynthia E Hawkins; Zachary F Pursell; Adam Shlien; Thomas A Kunkel
Journal:  Cancer Discov       Date:  2020-12-18       Impact factor: 39.397

6.  Spatial and phenotypic immune profiling of metastatic colon cancer.

Authors:  Jenny Lazarus; Tomasz Maj; J Joshua Smith; Mirna Perusina Lanfranca; Arvind Rao; Michael I D'Angelica; Lawrence Delrosario; Alexander Girgis; Casey Schukow; Jinru Shia; Ilona Kryczek; Jiaqi Shi; Isaac Wasserman; Howard Crawford; Hari Nathan; Marina Pasca Di Magliano; Weiping Zou; Timothy L Frankel
Journal:  JCI Insight       Date:  2018-11-15

Review 7.  Gutting it Out: Developing Effective Immunotherapies for Patients With Colorectal Cancer.

Authors:  Carolina Mendonça Gorgulho; Anuradha Krishnamurthy; Anastasia Lanzi; Jérôme Galon; Franck Housseau; Ramon Kaneno; Michael T Lotze
Journal:  J Immunother       Date:  2021 Feb-Mar 01       Impact factor: 4.912

8.  Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing.

Authors:  Russell Bonneville; Anoosha Paruchuri; Michele R Wing; Melanie A Krook; Julie W Reeser; Hui-Zi Chen; Thuy Dao; Eric Samorodnitsky; Amy M Smith; Lianbo Yu; Nicholas Nowacki; Wei Chen; Sameek Roychowdhury
Journal:  Mol Cancer Res       Date:  2020-11-23       Impact factor: 6.333

9.  Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy Targets.

Authors:  Chao Chen; Songming Liu; Ruokai Qu; Bo Li
Journal:  Biomed Res Int       Date:  2020-07-17       Impact factor: 3.411

Review 10.  Antigen processing and presentation in cancer immunotherapy.

Authors:  Maxwell Y Lee; Jun W Jeon; Cem Sievers; Clint T Allen
Journal:  J Immunother Cancer       Date:  2020-08       Impact factor: 13.751
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