Literature DB >> 27458980

Successful treatment of a disseminated infection with extensively drug-resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin-based multidrug regimen.

J P Mills1, M B Wilck2, B C Weikert2, P M Porrett3, D Timko4, K Alby5, R A Bonomo6,7, E A Blumberg2.   

Abstract

Donor-derived infections with multidrug-resistant gram-negative bacteria are associated with poor outcomes, in part because of limited treatment options. Here, we describe a case of donor-derived, disseminated infection with colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in a liver transplant recipient that was cured with addition of intravenous fosfomycin to a multidrug regimen, in conjunction with aggressive surgical source control. Intravenous fosfomycin represents a promising adjunctive agent for use in treatment of extensively drug-resistant infections in immunocompromised hosts.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  carbapenem-resistant Klebsiella pneumoniae (CRKP); extremely drug-resistant (XDR); fosfomycin; orthotopic liver transplantation (OLT)

Mesh：

Substances：

Year:  2016        PMID： 27458980      PMCID： PMC5050106          DOI： 10.1111/tid.12578

Source DB:  PubMed          Journal:  Transpl Infect Dis        ISSN： 1398-2273            Impact factor:   2.228


  12 in total

1.  Colonization and infection by colistin-resistant Gram-negative bacteria in a cohort of critically ill patients.

Authors:  F Kontopidou; D Plachouras; E Papadomichelakis; G Koukos; I Galani; G Poulakou; G Dimopoulos; A Antoniadou; A Armaganidis; H Giamarellou
Journal:  Clin Microbiol Infect       Date:  2011-09-21       Impact factor: 8.067

2.  Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among Gram-negative bacilli: need for international harmonization in terminology.

Authors:  Matthew E Falagas; Drosos E Karageorgopoulos
Journal:  Clin Infect Dis       Date:  2008-04-01       Impact factor: 9.079

Review 3.  The revival of fosfomycin.

Authors:  Argyris S Michalopoulos; Ioannis G Livaditis; Vassilios Gougoutas
Journal:  Int J Infect Dis       Date:  2011-09-25       Impact factor: 3.623

4.  Interaction of fosfomycin with other antimicrobial agents: in vitro and in vivo studies.

Authors:  T Olay; A Rodríguez; L E Oliver; M V Vicente; M C Quecedo
Journal:  J Antimicrob Chemother       Date:  1978-11       Impact factor: 5.790

5.  Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study.

Authors:  Olympia Zarkotou; Spyros Pournaras; Evangelia Voulgari; Georgios Chrysos; Athanassios Prekates; Dionysios Voutsinas; Katerina Themeli-Digalaki; Athanassios Tsakris
Journal:  J Clin Microbiol       Date:  2010-04-07       Impact factor: 5.948

Review 6.  What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review.

Authors:  Suzanne Parker; Jeffrey Lipman; Despoina Koulenti; George Dimopoulos; Jason A Roberts
Journal:  Int J Antimicrob Agents       Date:  2013-07-20       Impact factor: 5.283

7.  Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients.

Authors:  Jayant S Kalpoe; Edith Sonnenberg; Stephanie H Factor; Juan del Rio Martin; Thomas Schiano; Gopi Patel; Shirish Huprikar
Journal:  Liver Transpl       Date:  2012-04       Impact factor: 5.799

Review 8.  Fosfomycin: use beyond urinary tract and gastrointestinal infections.

Authors:  Matthew E Falagas; Konstantina P Giannopoulou; George N Kokolakis; Petros I Rafailidis
Journal:  Clin Infect Dis       Date:  2008-04-01       Impact factor: 9.079

9.  Fosfomycin susceptibility in carbapenem-resistant Enterobacteriaceae from Germany.

Authors:  Martin Kaase; Florian Szabados; Agnes Anders; Sören G Gatermann
Journal:  J Clin Microbiol       Date:  2014-03-19       Impact factor: 5.948

10.  Incidence of carbapenem-resistant gram negatives in Italian transplant recipients: a nationwide surveillance study.

Authors:  Simone Lanini; Alessandro Nanni Costa; Vincenzo Puro; Francesco Procaccio; Paolo Antonio Grossi; Francesca Vespasiano; Andrea Ricci; Sergio Vesconi; Michael G Ison; Yehuda Carmeli; Giuseppe Ippolito
Journal:  PLoS One       Date:  2015-04-02       Impact factor: 3.240
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  6 in total

Review 1.  Carbapenem-Resistant Enterobacteriaceae in Solid Organ Transplantation: Management Principles.

Authors:  Olivia Smibert; Michael J Satlin; Anoma Nellore; Anton Y Peleg
Journal:  Curr Infect Dis Rep       Date:  2019-06-10       Impact factor: 3.725

2.  Risk factors for multidrug-resistant organisms among deceased organ donors.

Authors:  Judith A Anesi; Emily A Blumberg; Jennifer H Han; Dong H Lee; Heather Clauss; Antonette Climaco; Richard Hasz; Esther Molnar; Darcy Alimenti; Sharon West; Warren B Bilker; Pam Tolomeo; Ebbing Lautenbach
Journal:  Am J Transplant       Date:  2019-06-26       Impact factor: 8.086

3.  "Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by blaNDM -harboring Enterobacteriaceae in kidney transplantation.

Authors:  Rossana Rosa; Susan D Rudin; Laura J Rojas; Andrea M Hujer; Armando Perez-Cardona; Federico Perez; Robert A Bonomo; Octavio Martinez; Lilian M Abbo; Jose F Camargo
Journal:  Transpl Infect Dis       Date:  2017-11-27       Impact factor: 2.228

4.  Case Report of an Extensively Drug-Resistant Klebsiella pneumoniae Infection With Genomic Characterization of the Strain and Review of Similar Cases in the United States.

Authors:  Fiorella Krapp; Egon A Ozer; Chao Qi; Alan R Hauser
Journal:  Open Forum Infect Dis       Date:  2018-04-06       Impact factor: 3.835

5.  Effects of preservative fluid associated possible donor-derived carbapenem-resistant Klebsiella Pneumoniae infection on kidney transplantation recipients.

Authors:  Fei Zhang; Jinbiao Zhong; Handong Ding; Guiyi Liao
Journal:  BMC Nephrol       Date:  2022-03-14       Impact factor: 2.388

6.  Donor-derived infections among Chinese donation after cardiac death liver recipients.

Authors:  Qi-Fa Ye; Wei Zhou; Qi-Quan Wan
Journal:  World J Gastroenterol       Date:  2017-08-21       Impact factor: 5.742
  6 in total

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