Literature DB >> 27458226

Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism.

Kaisong Huang1, Qiang Zhang1, Yajing Song1, Zhewen Zhang2, Anding Zhang1, Jingfa Xiao2, Meilin Jin3.   

Abstract

Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical Streptococcus suis isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance spw_like-aadE-lnu(B)-lsa(E) cluster and a cadmium resistance operon were identified, suggesting a possible cause for the wide dissemination of spectinomycin resistance in S. suis.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27458226      PMCID： PMC5038275          DOI： 10.1128/AAC.01157-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Two new gene cassettes, dfr17 (for trimethoprim resistance) and aadA4 (for spectinomycin/streptomycin resistance), inserted in an Escherichia coli class 1 integron.

Authors:  C Y Chang; L L Chang; Y H Chang; T M Lee; Y H Li; S F Chang
Journal:  J Antimicrob Chemother       Date:  2000-07       Impact factor: 5.790

2.  Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin.

Authors:  Hongbin Si; Wan-Jiang Zhang; Shengbo Chu; Xiu-Mei Wang; Lei Dai; Xin Hua; Zhimin Dong; Stefan Schwarz; Siguo Liu
Journal:  Antimicrob Agents Chemother       Date:  2015-08-31       Impact factor: 5.191

3.  Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licensed in veterinary medicine.

Authors:  Henk J Wisselink; Kees T Veldman; Chris Van den Eede; Sarah A Salmon; Dik J Mevius
Journal:  Vet Microbiol       Date:  2006-01-18       Impact factor: 3.293

4.  Identification of the novel lincosamide resistance gene lnu(E) truncated by ISEnfa5-cfr-ISEnfa5 insertion in Streptococcus suis: de novo synthesis and confirmation of functional activity in Staphylococcus aureus.

Authors:  Qin Zhao; Sarah Wendlandt; Hui Li; Jun Li; Congming Wu; Jianzhong Shen; Stefan Schwarz; Yang Wang
Journal:  Antimicrob Agents Chemother       Date:  2013-12-23       Impact factor: 5.191

5.  Presence and genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in enterococci of human and swine origin.

Authors:  Xin-Sheng Li; Wei-Chao Dong; Xiao-Ming Wang; Gong-Zheng Hu; Ya-Bin Wang; Bai-Yi Cai; Cong-Ming Wu; Yang Wang; Xiang-Dang Du
Journal:  J Antimicrob Chemother       Date:  2013-12-29       Impact factor: 5.790

6.  Identification of the novel spectinomycin resistance gene spw in methicillin-resistant and methicillin-susceptible Staphylococcus aureus of human and animal origin.

Authors:  Sarah Wendlandt; Beibei Li; Carmen Lozano; Zhiyong Ma; Carmen Torres; Stefan Schwarz
Journal:  J Antimicrob Chemother       Date:  2013-03-19       Impact factor: 5.790

7.  Presence and new genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in Erysipelothrix rhusiopathiae of swine origin.

Authors:  Anyun Zhang; Changwen Xu; Hongning Wang; Changwei Lei; Bihui Liu; Zhongbin Guan; Chunmei Yang; Yongqiang Yang; Linyao Peng
Journal:  Vet Microbiol       Date:  2015-02-25       Impact factor: 3.293

8.  Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens.

Authors:  Claudio Palmieri; Gloria Magi; Marina Mingoia; Patrizia Bagnarelli; Sandro Ripa; Pietro E Varaldo; Bruna Facinelli
Journal:  Antimicrob Agents Chemother       Date:  2012-06-18       Impact factor: 5.191

9.  Contribution of glutamine synthetase to the virulence of Streptococcus suis serotype 2.

Authors:  Youhui Si; Fangyan Yuan; Haitao Chang; Xijian Liu; Hongru Li; Kai Cai; Zhuofei Xu; Qinfeng Huang; Weicheng Bei; Huanchun Chen
Journal:  Vet Microbiol       Date:  2009-04-22       Impact factor: 3.293

10.  Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen.

Authors:  Claudio Palmieri; Pietro E Varaldo; Bruna Facinelli
Journal:  Front Microbiol       Date:  2011-11-25       Impact factor: 5.640
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  7 in total

1.  Adaptation in toxic environments: comparative genomics of loci carrying antibiotic resistance genes derived from acid mine drainage waters.

Authors:  Florence Arsène-Ploetze; Olfa Chiboub; Didier Lièvremont; Julien Farasin; Kelle C Freel; Stephanie Fouteau; Valérie Barbe
Journal:  Environ Sci Pollut Res Int       Date:  2017-10-31       Impact factor: 4.223

2.  New genetic context of lnu(B) composed of two multi-resistance gene clusters in clinical Streptococcus agalactiae ST-19 strains.

Authors:  Kaixin Zhou; Dongan Zhu; Ying Tao; Lianyan Xie; Lizhong Han; Yibo Zhang; Jingyong Sun
Journal:  Antimicrob Resist Infect Control       Date:  2019-07-15       Impact factor: 4.887

3.  Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China.

Authors:  Mingliu Wang; Pengcheng Du; Jianping Wang; Ruiting Lan; Jun Huang; Ming Luo; Yan Jiang; Jun Zeng; Yi Quan; Zhaohui Shi; Han Zheng
Journal:  Pathogens       Date:  2019-10-12

4.  Horizontal Transfer of Different erm(B)-Carrying Mobile Elements Among Streptococcus suis Strains With Different Serotypes.

Authors:  Li Chen; Jinhu Huang; Xinxin Huang; Yuping He; Junjie Sun; Xingyang Dai; Xiaoming Wang; Muhammad Shafiq; Liping Wang
Journal:  Front Microbiol       Date:  2021-03-26       Impact factor: 5.640

5.  Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.

Authors:  Nazreen F Hadjirin; Eric L Miller; Gemma G R Murray; Phung L K Yen; Ho D Phuc; Thomas M Wileman; Juan Hernandez-Garcia; Susanna M Williamson; Julian Parkhill; Duncan J Maskell; Rui Zhou; Nahuel Fittipaldi; Marcelo Gottschalk; A W Dan Tucker; Ngo Thi Hoa; John J Welch; Lucy A Weinert
Journal:  BMC Biol       Date:  2021-09-07       Impact factor: 7.431

6.  A Conjugative MDR pMG1-Like Plasmid Carrying the lsa(E) Gene of Enterococcus faecium With Potential Transmission to Staphylococcus aureus.

Authors:  Xiao-Mei Yan; Jing Wang; Xiao-Xia Tao; Hong-Bing Jia; Fan-Liang Meng; Hui Yang; Yuan-Hai You; Bo Zheng; Yuan Hu; Xiao-Xia Bu; Jian-Zhong Zhang
Journal:  Front Microbiol       Date:  2021-06-04       Impact factor: 5.640

7.  Chromosomal Conjugative and Mobilizable Elements in Streptococcus suis: Major Actors in the Spreading of Antimicrobial Resistance and Bacteriocin Synthesis Genes.

Authors:  Virginie Libante; Yves Nombre; Charles Coluzzi; Johan Staub; Gérard Guédon; Marcelo Gottschalk; Sarah Teatero; Nahuel Fittipaldi; Nathalie Leblond-Bourget; Sophie Payot
Journal:  Pathogens       Date:  2019-12-25
  7 in total

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