Jun-Ping Tian1, Hong Wang2, Feng-He Du3, Tao Wang4. 1. Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, Dongcheng District, Beijing, 100050, People's Republic of China. tianjp506@163.com. 2. Department of Endocrinology, Aerospace Center Hospital, Beijing, People's Republic of China. 3. Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, No. 6, Tian Tan Xi Li, Dongcheng District, Beijing, 100050, People's Republic of China. 4. Division of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100083, People's Republic of China. wangt@bjmu.edu.cn.
Abstract
PURPOSE: The mortality rate of peritoneal dialysis (PD) patients is still high, and the predicting factors for PD patient mortality remain to be determined. This study aimed to explore the relationship between the standard deviation (SD) of extracellular water/intracellular water (E/I) and all-cause mortality and technique failure in continuous ambulatory PD (CAPD) patients. METHODS: All 152 patients came from the PD Center between January 1st 2006 and December 31st 2007. Clinical data and at least five-visit E/I ratio defined by bioelectrical impedance analysis were collected. The patients were followed up till December 31st 2010. The primary outcomes were death from any cause and technique failure. Kaplan-Meier analysis and Cox proportional hazards models were used to identify risk factors for mortality and technique failure in CAPD patients. RESULTS: All patients were followed up for 59.6 ± 23.0 months. The patients were divided into two groups according to their SD of E/I values: lower SD of E/I group (≤0.126) and higher SD of E/I group (>0.126). The patients with higher SD of E/I showed a higher all-cause mortality (log-rank χ (2) = 10.719, P = 0.001) and technique failure (log-rank χ (2) = 9.724, P = 0.002) than those with lower SD of E/I. Cox regression analysis found that SD of E/I independently predicted all-cause mortality (HR 3.551, 95 % CI 1.442-8.746, P = 0.006) and technique failure (HR 2.487, 95 % CI 1.093-5.659, P = 0.030) in CAPD patients after adjustment for confounders except when sensitive C-reactive protein was added into the model. CONCLUSION: The SD of E/I was a strong independent predictor of all-cause mortality and technique failure in CAPD patients.
PURPOSE: The mortality rate of peritoneal dialysis (PD) patients is still high, and the predicting factors for PDpatient mortality remain to be determined. This study aimed to explore the relationship between the standard deviation (SD) of extracellular water/intracellular water (E/I) and all-cause mortality and technique failure in continuous ambulatory PD (CAPD) patients. METHODS: All 152 patients came from the PD Center between January 1st 2006 and December 31st 2007. Clinical data and at least five-visit E/I ratio defined by bioelectrical impedance analysis were collected. The patients were followed up till December 31st 2010. The primary outcomes were death from any cause and technique failure. Kaplan-Meier analysis and Cox proportional hazards models were used to identify risk factors for mortality and technique failure in CAPD patients. RESULTS: All patients were followed up for 59.6 ± 23.0 months. The patients were divided into two groups according to their SD of E/I values: lower SD of E/I group (≤0.126) and higher SD of E/I group (>0.126). The patients with higher SD of E/I showed a higher all-cause mortality (log-rank χ (2) = 10.719, P = 0.001) and technique failure (log-rank χ (2) = 9.724, P = 0.002) than those with lower SD of E/I. Cox regression analysis found that SD of E/I independently predicted all-cause mortality (HR 3.551, 95 % CI 1.442-8.746, P = 0.006) and technique failure (HR 2.487, 95 % CI 1.093-5.659, P = 0.030) in CAPD patients after adjustment for confounders except when sensitive C-reactive protein was added into the model. CONCLUSION: The SD of E/I was a strong independent predictor of all-cause mortality and technique failure in CAPD patients.
Entities:
Keywords:
Extracellular water; Intracellular water; Outcome; Peritoneal dialysis; Volume status
Authors: K Ateş; G Nergizoğlu; K Keven; A Sen; S Kutlay; S Ertürk; N Duman; O Karatan; A E Ertuğ Journal: Kidney Int Date: 2001-08 Impact factor: 10.612
Authors: R Asmar; A Benetos; J Topouchian; P Laurent; B Pannier; A M Brisac; R Target; B I Levy Journal: Hypertension Date: 1995-09 Impact factor: 10.190
Authors: Elizabeth Lindley; Yvette Devine; Lisa Hall; Mary Cullen; Suzanne Cuthbert; Graham Woodrow; Frantisek Lopot Journal: Perit Dial Int Date: 2005-02 Impact factor: 1.756
Authors: K D Nolph; H L Moore; B Prowant; M Meyer; Z J Twardowski; R Khanna; L Ponferrada; P Keshaviah Journal: Perit Dial Int Date: 1993 Impact factor: 1.756
Authors: Constantijn J A M Konings; Jeroen P Kooman; Marc Schonck; Ruben Dammers; Emiel Cheriex; Andrea P Palmans Meulemans; Arnold P G Hoeks; Bernardus van Kreel; Ulrich Gladziwa; Frank M van der Sande; Karel M L Leunissen Journal: Perit Dial Int Date: 2002 Jul-Aug Impact factor: 1.756
Authors: Matthew Tabinor; Emma Elphick; Michael Dudson; Chun Shing Kwok; Mark Lambie; Simon J Davies Journal: Sci Rep Date: 2018-03-13 Impact factor: 4.379
Authors: François Vrtovsnik; Christian Verger; Wim Van Biesen; Stanley Fan; Sug-Kyun Shin; Carmen Rodríguez; Isabel Garcia Méndez; Frank M van der Sande; Tatiana De Los Ríos; Katharina Ihle; Adelheid Gauly; Claudio Ronco; James Heaf Journal: Clin Kidney J Date: 2019-12-22