Elissa M Ozanne1, Julie E Weiss2, Tracy Onega3, Wendy DeMartini4, Karla Kerlikowske5, Diana S M Buist6, Louise Henderson7, Rebecca A Hubbard8, Martha Goodrich9, Anna N A Tosteson1, Beth A Virnig10, Cristina O'Donoghue11. 1. The Dartmouth Institute for Health Policy and Clinical Practice and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. 2. Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, 46 Centerra Parkway, Suite 105, Lebanon, NH 03766, USA. Electronic address: julie.weiss@dartmouth.edu. 3. The Dartmouth Institute for Health Policy and Clinical Practice and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, 46 Centerra Parkway, Suite 105, Lebanon, NH 03766, USA. 4. Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 5. Department of Medicine, University of California, San Francisco, CA, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. 6. Department of Epidemiology, Group Health Research Institute, Seattle, WA, USA. 7. Department of Radiology, The University of North Carolina, Chapel Hill, NC, USA. 8. Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA. 9. Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, 46 Centerra Parkway, Suite 105, Lebanon, NH 03766, USA. 10. Department of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA. 11. Department of Surgical Oncology, Surgical Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Abstract
BACKGROUND: Preoperative magnetic resonance imaging (MRI) use has increased among older women diagnosed with breast cancer. MRI detects additional malignancy, but its impact on locoregional surgery and radiation treatment remains unclear. METHODS: We examined the associations of preoperative MRI with initial locoregional treatment type (mastectomy, breast conserving surgery [BCS] with radiation therapy [RT], and BCS without RT) and BCS reoperation rates for Surveillance, Epidemiology, and End Results Medicare women diagnosed with stages 0 to III breast cancer from 2005 to 2009 (n = 55,997). RESULTS: We found no association of initial locoregional treatment of mastectomy (odds ratios [OR], 1.04; 95% confidence intervals, .98 to 1.11) or reoperation after initial BCS (OR, .96; 95% confidence intervals, .89 to 1.03) between women with preoperative MRI (16.2%) compared to women without MRI. However, women with MRI who had initial BCS were more likely to undergo RT (OR, 1.09 [1.02 to 1.16]). CONCLUSIONS: Preoperative breast MRI in Medicare-enrolled women with stages 0 to III breast cancer was not associated with increased mastectomy. However, in older women with MRI undergoing BCS, there was a greater use of RT.
BACKGROUND: Preoperative magnetic resonance imaging (MRI) use has increased among older women diagnosed with breast cancer. MRI detects additional malignancy, but its impact on locoregional surgery and radiation treatment remains unclear. METHODS: We examined the associations of preoperative MRI with initial locoregional treatment type (mastectomy, breast conserving surgery [BCS] with radiation therapy [RT], and BCS without RT) and BCS reoperation rates for Surveillance, Epidemiology, and End Results Medicare women diagnosed with stages 0 to III breast cancer from 2005 to 2009 (n = 55,997). RESULTS: We found no association of initial locoregional treatment of mastectomy (odds ratios [OR], 1.04; 95% confidence intervals, .98 to 1.11) or reoperation after initial BCS (OR, .96; 95% confidence intervals, .89 to 1.03) between women with preoperative MRI (16.2%) compared to women without MRI. However, women with MRI who had initial BCS were more likely to undergo RT (OR, 1.09 [1.02 to 1.16]). CONCLUSIONS: Preoperative breast MRI in Medicare-enrolled women with stages 0 to III breast cancer was not associated with increased mastectomy. However, in older women with MRI undergoing BCS, there was a greater use of RT.
Authors: Louise M Henderson; Julie Weiss; Rebecca A Hubbard; Cristina O'Donoghue; Wendy B DeMartini; Diana S M Buist; Karla Kerlikowske; Martha Goodrich; Beth Virnig; Anna N A Tosteson; Constance D Lehman; Tracy Onega Journal: Breast J Date: 2015-10-28 Impact factor: 2.431
Authors: Angel Arnaout; Christina Catley; Christopher M Booth; Matthew McInnes; Ian Graham; Vikaash Kumar; Demetrios Simos; Carl Van Walraven; Mark Clemons Journal: JAMA Oncol Date: 2015-12 Impact factor: 31.777
Authors: Shi-Yi Wang; Karen M Kuntz; Todd M Tuttle; David R Jacobs; Robert L Kane; Beth A Virnig Journal: Breast Cancer Res Treat Date: 2013-01-25 Impact factor: 4.872
Authors: Rajini Katipamula; Amy C Degnim; Tanya Hoskin; Judy C Boughey; Charles Loprinzi; Clive S Grant; Kathleen R Brandt; Sandhya Pruthi; Christopher G Chute; Janet E Olson; Fergus J Couch; James N Ingle; Matthew P Goetz Journal: J Clin Oncol Date: 2009-07-27 Impact factor: 44.544
Authors: Alice K Fortune-Greeley; Stephanie B Wheeler; Anne-Marie Meyer; Katherine E Reeder-Hayes; Andrea K Biddle; Hyman B Muss; William R Carpenter Journal: Breast Cancer Res Treat Date: 2013-12-04 Impact factor: 4.872