Tendy Chiang1, Victoria Pepper2, Cameron Best3, Ekene Onwuka4, Christopher K Breuer2. 1. Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA Department of Pediatric Otolaryngology, Nationwide Children's Hospital, Columbus, Ohio, USA Department of Otolaryngology-Head & Neck Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA Tendy.Chiang@nationwidechildrens.org. 2. Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA. 3. Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA. 4. Tissue Engineering and Surgical Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA Department of Surgery, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.
Abstract
OBJECTIVE: To provide a state-of-the-art review discussing recent achievements in tissue engineered tracheal reconstruction. DATA SOURCES AND REVIEW METHODS: A structured PubMed search of the current literature up to and including October 2015. Representative articles that discuss the translation of tissue engineered tracheal grafts (TETG) were reviewed. CONCLUSIONS: The integration of a biologically compatible support with autologous cells has resulted in successful regeneration of respiratory epithelium, cartilage, and vascularization with graft patency, although the optimal construct composition has yet to be defined. Segmental TETG constructs are more commonly complicated by stenosis and delayed epithelialization when compared to patch tracheoplasty. IMPLICATIONS FOR PRACTICE: The recent history of human TETG recipients represents revolutionary proof of principle studies in regenerative medicine. Application of TETG remains limited to a compassionate use basis; however, defining the mechanisms of cartilage formation, epithelialization, and refinement of in vivo regeneration will advance the translation of TETG from the bench to the bedside.
OBJECTIVE: To provide a state-of-the-art review discussing recent achievements in tissue engineered tracheal reconstruction. DATA SOURCES AND REVIEW METHODS: A structured PubMed search of the current literature up to and including October 2015. Representative articles that discuss the translation of tissue engineered tracheal grafts (TETG) were reviewed. CONCLUSIONS: The integration of a biologically compatible support with autologous cells has resulted in successful regeneration of respiratory epithelium, cartilage, and vascularization with graft patency, although the optimal construct composition has yet to be defined. Segmental TETG constructs are more commonly complicated by stenosis and delayed epithelialization when compared to patch tracheoplasty. IMPLICATIONS FOR PRACTICE: The recent history of humanTETG recipients represents revolutionary proof of principle studies in regenerative medicine. Application of TETG remains limited to a compassionate use basis; however, defining the mechanisms of cartilage formation, epithelialization, and refinement of in vivo regeneration will advance the translation of TETG from the bench to the bedside.
Authors: Stephen F Badylak; Jolene E Valentin; Anjani K Ravindra; George P McCabe; Ann M Stewart-Akers Journal: Tissue Eng Part A Date: 2008-11 Impact factor: 3.845
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Authors: Ja H Lee; Hae S Park; Se H Oh; Jin H Lee; Jin R Kim; Hyun J Kim; Soo Y Jung; Sung M Chung; Hong S Choi; Han S Kim Journal: Laryngoscope Date: 2014-07-01 Impact factor: 3.325
Authors: Philipp Jungebluth; Johannes C Haag; Mei L Lim; Greg Lemon; Sebastian Sjöqvist; Ylva Gustafsson; Fatemeh Ajalloueian; Irina Gilevich; Oscar E Simonson; Karl H Grinnemo; Matthias Corbascio; Silvia Baiguera; Costantino Del Gaudio; Staffan Strömblad; Paolo Macchiarini Journal: Biomaterials Date: 2013-03-06 Impact factor: 12.479
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Authors: Nicholas Hamilton; Anthony J Bullock; Sheila Macneil; Sam M Janes; Martin Birchall Journal: Laryngoscope Date: 2013-11-19 Impact factor: 3.325
Authors: Alex Danielson; Lumei Liu; Kimberly M Shontz; Hassan Syed; Sayali Dharmadhikari; Susan D Reynolds; Christopher K Breuer; Tendy Chiang Journal: Laryngoscope Date: 2020-06-10 Impact factor: 3.325
Authors: Victoria K Pepper; Ekene A Onwuka; Cameron A Best; Nakesha King; Eric Heuer; Jed Johnson; Christopher K Breuer; Jonathan M Grischkan; Tendy Chiang Journal: Laryngoscope Date: 2017-03-27 Impact factor: 3.325
Authors: Victoria Pepper; Cameron A Best; Kaila Buckley; Cynthia Schwartz; Ekene Onwuka; Nakesha King; Audrey White; Sayali Dharmadhikari; Susan D Reynolds; Jed Johnson; Jonathan Grischkan; Christopher K Breuer; Tendy Chiang Journal: Otolaryngol Head Neck Surg Date: 2019-04-30 Impact factor: 3.497
Authors: Cameron A Best; Victoria K Pepper; Devan Ohst; Kyle Bodnyk; Eric Heuer; Ekene A Onwuka; Nakesha King; Robert Strouse; Jonathan Grischkan; Christopher K Breuer; Jed Johnson; Tendy Chiang Journal: Int J Pediatr Otorhinolaryngol Date: 2017-11-22 Impact factor: 1.675
Authors: Matthew G Wiet; Sayali Dharmadhikari; Audrey White; Susan D Reynolds; Jed Johnson; Christopher K Breuer; Tendy Chiang Journal: J Vis Exp Date: 2019-04-01 Impact factor: 1.355
Authors: Zheng Hong Tan; Sayali Dharmadhikari; Lumei Liu; Gabrielle Wolter; Kimberly M Shontz; Susan D Reynolds; Jed Johnson; Christopher K Breuer; Tendy Chiang Journal: Laryngoscope Date: 2021-06-21 Impact factor: 3.325