PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY) variables and Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany) tomographic parameters in differentiating forme fruste keratoconus (FFKC) from normal corneas, and to assess a combined biomechanical and tomographic parameter to improve outcomes. METHODS: Seventy-six eyes of 76 normal patients and 21 eyes of 21 patients with FFKC were included in the study. Fifteen variables were derived from exported ORA signals to characterize putative indicators of biomechanical behavior and 37 ORA waveform parameters were tested. Sixteen tomographic parameters from Pentacam HR were tested. Logistic regression was used to produce a combined biomechanical and tomography linear model. Differences between groups were assessed by the Mann-Whitney U test. The area under the receiver operating characteristics curve (AUROC) was used to compare diagnostic performance. RESULTS: No statistically significant differences were found in age, thinnest point, central corneal thickness, and maximum keratometry between groups. Twenty-one parameters showed significant differences between the FFKC and control groups. Among the ORA waveform measurements, the best parameters were those related to the area under the first peak, p1area1 (AUROC, 0.717 ± 0.065). Among the investigator ORA variables, a measure incorporating the pressure-deformation relationship of the entire response cycle was the best predictor (hysteresis loop area, AUROC, 0.688 ± 0.068). Among tomographic parameters, Belin/Ambrósio display showed the highest predictive value (AUROC, 0.91 ± 0.057). A combination of parameters showed the best result (AUROC, 0.953 ± 0.024) outperforming individual parameters. CONCLUSIONS: Tomographic and biomechanical parameters demonstrated the ability to differentiate FFKC from normal eyes. A combination of both types of information further improved predictive value. [J Refract Surg. 2016;32(7):479-485.]. Copyright 2016, SLACK Incorporated.
PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY) variables and Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany) tomographic parameters in differentiating forme fruste keratoconus (FFKC) from normal corneas, and to assess a combined biomechanical and tomographic parameter to improve outcomes. METHODS: Seventy-six eyes of 76 normal patients and 21 eyes of 21 patients with FFKC were included in the study. Fifteen variables were derived from exported ORA signals to characterize putative indicators of biomechanical behavior and 37 ORA waveform parameters were tested. Sixteen tomographic parameters from Pentacam HR were tested. Logistic regression was used to produce a combined biomechanical and tomography linear model. Differences between groups were assessed by the Mann-Whitney U test. The area under the receiver operating characteristics curve (AUROC) was used to compare diagnostic performance. RESULTS: No statistically significant differences were found in age, thinnest point, central corneal thickness, and maximum keratometry between groups. Twenty-one parameters showed significant differences between the FFKC and control groups. Among the ORA waveform measurements, the best parameters were those related to the area under the first peak, p1area1 (AUROC, 0.717 ± 0.065). Among the investigator ORA variables, a measure incorporating the pressure-deformation relationship of the entire response cycle was the best predictor (hysteresis loop area, AUROC, 0.688 ± 0.068). Among tomographic parameters, Belin/Ambrósio display showed the highest predictive value (AUROC, 0.91 ± 0.057). A combination of parameters showed the best result (AUROC, 0.953 ± 0.024) outperforming individual parameters. CONCLUSIONS: Tomographic and biomechanical parameters demonstrated the ability to differentiate FFKC from normal eyes. A combination of both types of information further improved predictive value. [J Refract Surg. 2016;32(7):479-485.]. Copyright 2016, SLACK Incorporated.
Authors: Renato Ambrósio; Ana Laura C Caiado; Frederico P Guerra; Ricardo Louzada; Roy A Sinha; Allan Luz; William J Dupps; Michael W Belin Journal: J Refract Surg Date: 2011-07-29 Impact factor: 3.573
Authors: Eric S Hwang; Claudia E Perez-Straziota; Sang Woo Kim; Marcony R Santhiago; J Bradley Randleman Journal: Ophthalmology Date: 2018-07-25 Impact factor: 12.079
Authors: Mustafa Değer Bilgeç; Eray Atalay; Ömer Sözer; Hüseyin Gürsoy; Muzaffer Bilgin; Nilgün Yıldırım Journal: Int Ophthalmol Date: 2019-12-02 Impact factor: 2.031
Authors: Oren Golan; Andre L Piccinini; Eric S Hwang; Ildamaris Montes De Oca Gonzalez; Mark Krauthammer; Sumitra S Khandelwal; David Smadja; J Bradley Randleman Journal: Am J Ophthalmol Date: 2019-02-02 Impact factor: 5.258
Authors: Bernardo T Lopes; Prema Padmanabhan; Ashkan Eliasy; Haixia Zhang; Ahmed Abass; Ahmed Elsheikh Journal: Front Bioeng Biotechnol Date: 2022-06-08
Authors: Renato Ambrósio; Fernando Faria Correia; Bernardo Lopes; Marcella Q Salomão; Allan Luz; Daniel G Dawson; Ahmed Elsheikh; Riccardo Vinciguerra; Paolo Vinciguerra; Cynthia J Roberts Journal: Open Ophthalmol J Date: 2017-07-31