| Literature DB >> 27383373 |
Jinyoung Kang1, Jinmyoung Joo2, Ester J Kwon3, Matthew Skalak3, Sazid Hussain4, Zhi-Gang She4, Erkki Ruoslahti4,5, Sangeeta N Bhatia3,6,7,8, Michael J Sailor9,10,11.
Abstract
Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.Entities:
Keywords: gene knockdowns; injured brains; photoluminescence; rabies virus glycoprotein peptides; targeted nanoparticles
Mesh:
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Year: 2016 PMID: 27383373 PMCID: PMC6274592 DOI: 10.1002/adma.201600634
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849