Literature DB >> 27368963

Inhibitory effect of alpha-mangostin on Candida biofilms.

Ruchadaporn Kaomongkolgit1, Kusuma Jamdee2.   

Abstract

The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant.

Entities:  

Keywords:  Alpha-mangostin; Anti-biofilm; Candida species

Mesh：

Substances：

Year:  2016        PMID： 27368963     DOI： 10.1007/s10266-016-0256-3

Source DB:  PubMed          Journal:  Odontology        ISSN： 1618-1247            Impact factor:   2.634


  19 in total

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7.  Antifungal activity of alpha-mangostin against Candida albicans.

Authors:  Ruchadaporn Kaomongkolgit; Kusuma Jamdee; Niratcha Chaisomboon
Journal:  J Oral Sci       Date:  2009-09       Impact factor: 1.556

Review 8.  Molecular and cellular mechanisms that lead to Candida biofilm formation.

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9.  Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.

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Journal:  Odontology       Date:  2014-06-03       Impact factor: 2.634

10.  Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative.

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