Literature DB >> 24888491

Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts.

Ichaya Yiemwattana1, Ruchadaporn Kaomongkolgit2.   

Abstract

This study aims to investigate the effect of alpha-mangostin on interleukin (IL)-6 and IL-8 expression in human gingival fibroblasts (HGFs). HGFs were challenged with Porphyromonas gingivalis LPS and then treated with various concentrations of alpha-mangostin. The cytotoxicity was determined using MTS assay and cytokine expressions were evaluated by Real-time PCR and ELISA. The results showed that 5 μg/ml P. gingivalis LPS and alpha-mangostin at 1 µg/ml or less did not affect the viability of HGFs. Alpha-mangostin reduced IL-6 and IL-8 mRNA and protein in P. gingivalis LPS-stimulated HGFs. These findings suggested that alpha-mangostin might be used as an adjunct to the periodontal therapy.

Entities:  

Keywords:  Alpha-mangostin; HGFs; IL-6/8

Mesh：

Substances：

Year:  2014        PMID： 24888491     DOI： 10.1007/s10266-014-0160-7

Source DB:  PubMed          Journal:  Odontology        ISSN： 1618-1247            Impact factor:   2.634


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