Literature DB >> 19776506

Antifungal activity of alpha-mangostin against Candida albicans.

Ruchadaporn Kaomongkolgit1, Kusuma Jamdee, Niratcha Chaisomboon.   

Abstract

This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 microg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 microg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis.

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Year:  2009        PMID： 19776506     DOI： 10.2334/josnusd.51.401

Source DB:  PubMed          Journal:  J Oral Sci        ISSN： 1343-4934            Impact factor:   1.556


  26 in total

1.  A Method of Effectively Improved α-Mangostin Bioavailability.

Authors:  Yan Zhao; Guosheng Tang; Qiang Tang; Jing Zhang; Yingying Hou; Enbo Cai; Shuangli Liu; Daihong Lei; Lianxue Zhang; Shijie Wang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2015-05-20       Impact factor: 2.441

2.  Fabrication and In Vitro/In Vivo Performance of Mucoadhesive Electrospun Nanofiber Mats Containing α-Mangostin.

Authors:  Wipada Samprasit; Theerasak Rojanarata; Prasert Akkaramongkolporn; Tanasait Ngawhirunpat; Ruchadaporn Kaomongkolgit; Praneet Opanasopit
Journal:  AAPS PharmSciTech       Date:  2015-02-26       Impact factor: 3.246

3.  Fast-acting clotrimazole composited PVP/HPβCD nanofibers for oral candidiasis application.

Authors:  Prasopchai Tonglairoum; Tanasait Ngawhirunpat; Theerasak Rojanarata; Ruchadaporn Kaomongkolgit; Praneet Opanasopit
Journal:  Pharm Res       Date:  2014-02-20       Impact factor: 4.200

4.  Inhibitory effect of alpha-mangostin on Candida biofilms.

Authors:  Ruchadaporn Kaomongkolgit; Kusuma Jamdee
Journal:  Odontology       Date:  2016-07-01       Impact factor: 2.634

5.  Molecular identification of fungi colonizing art objects in Thailand and their growth inhibition by local plant extracts.

Authors:  Witsanu Senbua; Jesdawan Wichitwechkarn
Journal:  3 Biotech       Date:  2019-09-05       Impact factor: 2.406

6.  In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.

Authors:  Abdalrahim F A Aisha; Khalid M Abu-Salah; Zhari Ismail; Amin Malik Shah Abdul Majid
Journal:  BMC Complement Altern Med       Date:  2012-07-20       Impact factor: 4.782

7.  α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.

Authors:  Xiaofang Quan; Yi Wang; Xiaofeng Ma; Yan Liang; Weixi Tian; Qingyun Ma; Hezhong Jiang; Youxing Zhao
Journal:  PLoS One       Date:  2012-03-09       Impact factor: 3.240

8.  Antimicrobial and Anti-inflammatory Effects of α-Mangostin Soluble Film.

Authors:  Piyawat Tangsuksan; Teerapol Srichana; Matana Kettratad; Wipawee Nittayananta
Journal:  J Int Soc Prev Community Dent       Date:  2022-04-08

9.  A study on dispersion and characterisation of α-mangostin loaded pH sensitive microgel systems.

Authors:  Madihah Ahmad; Bohari M Yamin; Azwan Mat Lazim
Journal:  Chem Cent J       Date:  2013-05-16       Impact factor: 4.215

10.  Mangosteen pericarp extract inhibits the formation of pentosidine and ameliorates skin elasticity.

Authors:  Rei-Ichi Ohno; Narumi Moroishi; Hikari Sugawa; Kazuhiro Maejima; Musashi Saigusa; Mikihiro Yamanaka; Mime Nagai; Morio Yoshimura; Yoshiaki Amakura; Ryoji Nagai
Journal:  J Clin Biochem Nutr       Date:  2015-04-16       Impact factor: 3.114
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