Literature DB >> 27358893

Long non-coding RNA regulation of liver cancer stem cell self-renewal offers new therapeutic targeting opportunities.

Mansi A Parasramka1, Tushar Patel1.   

Abstract

Long non-coding RNAs (lncRNA) are critical regulators of gene expression, and can reprogram the transcriptome to modulate cellular processes involved in cellular growth and differentiation, and thereby contribute to tumorigenesis. In addition to effects on tumor cell growth, survival and cell signaling, lncRNA can modulate cancer stem cell (CSC) behavior, including the expression of pluripotency factors. The identification of lncRNA that are mechanistically linked to cancer stem cell self-renewal and differentiation, or aberrant signaling pathways associated with tumor growth or progression, offer new opportunities for therapeutic intervention.

Entities:  

Keywords:  Long non-coding RNAs (lncRNA); cancer stem cells (CSC); hepatocellular carcinoma (HCC)

Year:  2016        PMID： 27358893      PMCID： PMC4923661          DOI： 10.3978/j.issn.2306-9759.2016.01.01

Source DB:  PubMed          Journal:  Stem Cell Investig        ISSN： 2306-9759


  13 in total

1.  The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.

Authors:  Yanying Wang; Lei He; Ying Du; Pingping Zhu; Guanling Huang; Jianjun Luo; Xinlong Yan; Buqing Ye; Chong Li; Pengyan Xia; Geng Zhang; Yong Tian; Runsheng Chen; Zusen Fan
Journal:  Cell Stem Cell       Date:  2015-04-02       Impact factor: 24.633

2.  SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells.

Authors:  Elif Eroglu; Thomas R Burkard; Yanrui Jiang; Nidhi Saini; Catarina C F Homem; Heinrich Reichert; Juergen A Knoblich
Journal:  Cell       Date:  2014-03-13       Impact factor: 41.582

Review 3.  Progress and Prospects of Long Noncoding RNAs (lncRNAs) in Hepatocellular Carcinoma.

Authors:  Chen Li; Jing Chen; Kai Zhang; Bing Feng; Rui Wang; Longbang Chen
Journal:  Cell Physiol Biochem       Date:  2015-05-11

4.  Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.

Authors:  Wei Gao; Heungnam Kim; Mingqian Feng; Yen Phung; Charles P Xavier; Jeffrey S Rubin; Mitchell Ho
Journal:  Hepatology       Date:  2014-06-18       Impact factor: 17.425

Review 5.  Long noncoding RNA in liver diseases.

Authors:  Kenji Takahashi; Irene Yan; Hiroaki Haga; Tushar Patel
Journal:  Hepatology       Date:  2014-06-20       Impact factor: 17.425

Review 6.  Cancer stem cells in the development of liver cancer.

Authors:  Taro Yamashita; Xin Wei Wang
Journal:  J Clin Invest       Date:  2013-05-01       Impact factor: 14.808

7.  CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA.

Authors:  Alice Conigliaro; Viviana Costa; Alessia Lo Dico; Laura Saieva; Simona Buccheri; Francesco Dieli; Mauro Manno; Samuele Raccosta; Carmine Mancone; Marco Tripodi; Giacomo De Leo; Riccardo Alessandro
Journal:  Mol Cancer       Date:  2015-08-14       Impact factor: 27.401

8.  Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition.

Authors:  Jun Wu; Jun Zhang; Bin Shen; Kai Yin; Jianwei Xu; Wencan Gao; Lihong Zhang
Journal:  J Exp Clin Cancer Res       Date:  2015-10-09

9.  Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535.

Authors:  Roberto Gedaly; Roberto Galuppo; Michael F Daily; Malay Shah; Erin Maynard; Changguo Chen; Xiping Zhang; Karyn A Esser; Donald A Cohen; B Mark Evers; Jieyun Jiang; Brett T Spear
Journal:  PLoS One       Date:  2014-06-18       Impact factor: 3.240

Review 10.  Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer.

Authors:  Swathi Mohankumar; Tushar Patel
Journal:  Brief Funct Genomics       Date:  2015-12-03       Impact factor: 4.241
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  2 in total

Review 1.  The emerging role of lncRNAs in the regulation of cancer stem cells.

Authors:  Rosario Castro-Oropeza; Jorge Melendez-Zajgla; Vilma Maldonado; Karla Vazquez-Santillan
Journal:  Cell Oncol (Dordr)       Date:  2018-09-14       Impact factor: 6.730

2.  Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma.

Authors:  Xiulan Zhao; Baocun Sun; Tieju Liu; Bing Shao; Ran Sun; Dongwang Zhu; Yanhui Zhang; Qiang Gu; Xueyi Dong; Fang Liu; Nan Zhao; Danfang Zhang; Yanlei Li; Jie Meng; Wenchen Gong; Yanjun Zheng; Xu Zheng
Journal:  Cancer Sci       Date:  2018-08-14       Impact factor: 6.716
  2 in total

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